The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...

Gabaa may refer to: Gabâ, the concept of divine retribution in parts of the Philippines GABAA may refer to: GABAA receptor Gaaba, an Indian dish prepared...

central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic...

neurotransmitter systems with enhanced functions are: GABAA, 5-HT3 receptor agonism (responsible for GABAergic (GABAA receptor PAM), glycinergic, and cholinergic...

In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator...

securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Other agents which may have GABAA receptor antagonism include the antibiotic...

GABA is γ-aminobutyrate. Two general classes of GABA receptor are known: GABAA in which the receptor is part of a ligand-gated ion channel complex GABAB...

mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptor and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity...

The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors...

is a GABAA receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABAA receptors...

of GABAA receptors. GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to the GABAA receptor...

It is a neurosteroid and acts as a positive allosteric modulator of the GABAA receptor, the major biological target of the inhibitory neurotransmitter...

mechanisms of action, both through potentiation of GABAA receptor activity and therefore acting as a GABAA receptor positive allosteric modulator, thereby...

the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety)...

brand names in parentheses. EVT-201 – GABAA receptor positive allosteric modulator[1] Lorediplon (GF-015535-00) – GABAA receptor positive allosteric modulator...

the brain, binding to GABA receptors and inhibiting neuronal signaling. GABAA receptor ligands include: Abecarnil Barbiturates (in high doses) Etomidate...

GABAA receptor desensitization results in unopposed excitatory neurotransmission (i.e., fewer inhibitory postsynaptic potentials occur through GABAA receptors)...

imidazopyridine family, structurally related to the Z-drug zolpidem, and acts as a GABAA receptor positive allosteric modulator of the benzodiazepine site of the...

Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM...

A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel...

5α-androstane-3α,17β-diol – GABAA receptor positive allosteric modulator 3α,5β-Androstanediol (etiocholanediol): 5β-androstane-3α,17β-diol – GABAA receptor positive...

U-93631 is a GABAA receptor antagonist. The mechanism of action of this compound is not entirely clear, but research shows that it binds to the GABAA receptor...

MRK-409, also known as MK-0343, is a GABAA receptor partial agonist. It was designed to be a non-sedative anxiolytic, however its development was halted...

α2, α3, and α5 subunit-containing GABAA receptors, with minimal functional activity at α1 subunit-containing GABAA receptors. A dose of darigabat that...

acid) – constituent of valerian; has anticonvulsant effects; PAM of the GABAA receptor Derivatives: isovalerate (isopentanoate/3-methylbutanoate), menthyl...

Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective GABAA receptor antagonist administered via injection, otic insertion, or intranasally...

QH-ii-066 is a highly subtype-selective GABAA agonist which was designed to bind selectively to the α5 subtype of GABAA receptors. The α5 subtype (and to a...

are positive allosteric modulators of the GABA type A receptors (GABAA). The GABAA receptors are ligand-gated chloride-selective ion channels that are...

benzodiazepines is complex and involves GABAA receptor downregulation, alterations to subunit configuration of GABAA receptors, uncoupling and internalisation...

activity that may stimulate muscles. Some studies show that menthol acts as a GABAA receptor positive allosteric modulator and increases GABAergic transmission...