Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and...

The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells)...

group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific hexokinase found in the liver. All hexokinases are...

is converted to F1P in the liver. This negates the action of F6P on glucokinase, which ultimately favors the forward reaction. The capacity of liver...

cells. Due to this, Glucokinase and glucokinase activators are the focus of treatment for those with type 2 diabetes mellitus. Glucokinase have a single allosteric...

Glucokinase regulator is a protein that in humans is encoded by the GCKR gene. This gene encodes a protein belonging to the GCKR subfamily of the SIS...

intracellular starch or glycogen. In animals, an isozyme of hexokinase called glucokinase is also used in the liver, which has a much lower affinity for glucose...

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction ADP...

human chromosome 7 for glucokinase. Glucokinase serves as the glucose sensor for the pancreatic beta cell. Normal glucokinase triggers insulin secretion...

mutations of transcription factor genes. One form is due to mutations of the glucokinase gene. For each form of MODY, multiple specific mutations involving different...

levels. Glucose is converted into glucose 6-phosphate by the action of glucokinase or hexokinase with conversion of ATP to ADP. Glucose-6-phosphate is converted...

first enzyme in the glycolysis pathway, has a specialized form called glucokinase expressed in the liver and pancreas that has a lower affinity for glucose...

the association of insulin and SREBP-1 lead to the gene expression of glucokinase. The interaction of glucose and lipogenic gene expression is assumed...

Cadisegliatin (TTP399) is a liver-selective glucokinase activator. It is being developed by VTV Therapeutics for treatment of type 2 diabetes or type...

for his contributions in diabetes research, specifically the work of Glucokinase activation as a treatment therapy for type 2 diabetes. Ramakanth Sarabu...

there as a cellular glycogen. In the liver cell, it is phosphorylated by glucokinase at position 6 to form glucose 6-phosphate, which cannot leave the cell...

for hexokinase A (brain hexokinase) to about 50 mM for hexokinase D ("glucokinase", liver hexokinase), more than a 2000-fold range. It would be impossible...

conventional glucokinase and phosphofructokinase, two novel sugar kinase have been discovered. These enzymes are ADP-dependent glucokinase (ADP-GK) and...

catalyzed by the enzyme hexokinase in most cells, and, in higher animals, glucokinase in certain cells, most notably liver cells. One equivalent of ATP is...

Catholic novelist and author GK Barry, English influencer and presenter Glucokinase, an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate...

fitness, and be favoured by natural selection. An example of an isozyme is glucokinase, a variant of hexokinase which is not inhibited by glucose 6-phosphate...

insulin-producing pancreatic islets and ultimately discovered the essential role of glucokinase (liver and pancreas hexokinase) in the regulation of glucose-stimulated...

concentration gradient through the GLUT2 transporter. Since beta cells use glucokinase to catalyze the first step of glycolysis, metabolism only occurs around...

Globalagliatin (SY-004) is a glucokinase activator developed by Yabao Pharmaceutical Group for type 2 diabetes. Zhao, Yuqing; Xie, Lijun; Zhang, Hongwen;...

obesity and type 2 diabetes. This includes research identifying the genes glucokinase and HNF1 risk factors for type 2 diabetes. In 2007, he was elected to...

encoding protein GEN1, Holliday junction 5' flap endonuclease GCKR: Glucokinase regulator GFPT1: glutamine—fructose-6-phosphate transaminase 1 GKN1:...

and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate...

two sugar monosaccharides, glucose and galactose. Another example is Glucokinase, which is an enzyme involved in the phosphorylation of glucose to glucose-6-phosphate...

a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin. MODY 4 is so rare that only a single family has been...

reactions are replaced with more kinetically favorable reactions. Hexokinase/glucokinase, phosphofructokinase, and pyruvate kinase enzymes of glycolysis are replaced...