shock factor 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional...

shock factor 1 (HSF1). There are four different transcription factors found in vertebrates (HSF 1–4) where the main regulator of HSPs is HSF1, while σ32 is...

complex. Thus, the MS2 protein is engineered to include p65 and HSF1 proteins. The MS2-p65-HSF1 fusion protein interacts with the dCas9-VP64 to recruit more...

expression. Recently it was discovered that HSF1 is a powerful multifaceted modifier of carcinogenesis. HSF1 knockout mice show significantly decreased...

in humans is encoded by the HSF2 gene. HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and...

"Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway". PLOS Biology. 17 (3): e2006966. doi:10.1371/journal.pbio...

ENSG00000128709 Homeodomain Known motif – High-throughput in vitro [410] TTTTATKRC HSF1 ENSG00000185122 HSF Known motif – High-throughput in vitro [411] VGAABVTTCBVGAW...

molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1. The downstream molecules that are inhibited by JNK activation include NFAT4...

chaperone proteins, inhibition of proteasome function and activation of HSF1, which triggers the heat shock response. The available evidence indicates...

dissociation of inactive HSF1 from complexes with heat shock proteins Hsp40/Hsp70 and Hsp90. With help from the ncRNA hsr1, HSF1 then trimerizes, becoming...

role in the regulation of proteostasis, by catalyzing the trimerization of HSF1 (Heat Shock Factor 1) and thus the body's response to heat shock. In the...

over whether the protein can bind DNA. An example of this is the protein HSF1, which remains bound to Hsp70 in the cytosol and is only translocated into...

heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4): 471–80. doi:10...

genes involved in pro-tumorigenic pathways including heat shock factor 1 (HSF1). They can also interfere with the function of tumour suppressor genes, such...

junctions in some cell types. SYMPK has been shown to interact with CSTF2, HSF1 and Oct4 GRCh38: Ensembl release 89: ENSG00000125755 – Ensembl, May 2017...

ISSN 0004-6361. Bally, J. (December 2008). "Overview of the Orion complex". Hsf1. 4: 459. Bibcode:2008hsf1.book..459B. Großschedl, Josefa E.; Alves, João;...

proteins bind to the misfolded proteins and dissociate from HSF-1. This allows HSF1 to form trimers and translocate to the cell nucleus and activate transcription...

Research studying the role of the master regulator of the heat shock response, HSF1, in the development of cancer. In 2013, he started his research laboratory...

antigen (PSA), dopamine, and the non-classical oncogene, heat shock factor 1 (HSF1). Aptamers have been generated against cancer cells, prions, bacteria, and...

Luke; Lamia, Katja A. (30 September 2022). "Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras -driven lung cancer". Science Advances...

Turning up the heat: the effects of thermal acclimation on the kinetics of HSF1 DNA-binding activity and Hsp70 gene expression in the eurythermal goby, Gillichthys...

HGNC:23238 Q9BPX1 7296 HSDL1 HGNC:16475 Q3SXM5 7297 HSDL2 HGNC:18572 Q6YN16 7298 HSF1 HGNC:5224 Q00613 7299 HSF2 HGNC:5225 Q03933 7300 HSF2BP HGNC:5226 O75031...

heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4): 471–480. doi:10...

estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor". Cell Stress & Chaperones. 1 (4): 237–250...

of Bcl-2 proteins which is an anti-apoptotic protein. The activation of HSF1 is the primary mechanism by which heat shock, proteasome inhibition, oxidative...

PMID 21693594. Hu Y, Mivechi NF (2011). "Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L)"...

immediately to its N-terminal. 9aaTAD transcription factors p53, VP16, MLL, E2A, HSF1, NF-IL6, NFAT1 and NF-κB interact directly with the general coactivators...

Azadirachta indica, deoxygedunin has additionally been found to activate HSF1 and induce Hsp70, and was observed to possess neuroprotective effects in...

PMID 10811890. Shi, Y. D. Mosser; Morimoto, R.I. (1998). "Molecular Chaperones as HSF1 Specific Transcriptional Repressors". Genes & Development. 12 (5): 654–666...

affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc...