total body clearance is equal to the sum clearance of the substance by each organ (e.g., renal clearance + hepatic clearance + lung clearance = total body...

Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ...

Pelkonen O.; Turpeinen M. (2007). "In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct...

ketoconazole, nefazodone, propoxyphene, and ritonavir delay the hepatic clearance of alprazolam, which may result in its accumulation and increased...

pharmacokinetic profile of zafirlukast. The hepatic clearance of zafirlukast is impaired by significant hepatic impairment. Cirrhosis of the liver can result...

time. Clearance can be determined on an overall, organism level («systemic clearance») or at an organ level (hepatic clearance, renal clearance etc.)...

1042/bj3220567. PMC 1218227. PMID 9065778. Svistounov D, Smedsrød B (2004). "Hepatic clearance of advanced glycation end products (AGEs)—myth or truth?". J. Hepatol...

concentration [Tmax] Protein binding [%] Bioavailability [%] Renal/hepatic clearance [%] Food effect Daily dosage [mg] Metabolism/transporter Losartan...

syndrome and acute fatty liver of pregnancy. These cause DI by impairing hepatic clearance of circulating vasopressinase. Electrolyte and volume homeostasis...

antibiotics, macrolide antibiotics, and propranolol) can decrease the hepatic clearance of doxofylline, which can result in increased serum levels of doxofylline...

play complementary roles in the hepatic blood clearance process, referred to as the dual cell principle of waste clearance (6): LSECs clear macromolecules...

discovery, such as solubility, permeability through biological membranes, hepatic clearance, lack of selectivity and non-specific toxicity. For oral drugs, a...

Higuchi O, Nakamura T, Sugiyama Y (April 1993). "Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats"...

Itraconazole can decrease busulfan clearance by up to 25%, resulting in AUC levels >1500 micromolxmin and increased risk of hepatic VOD. Concomitant use of acetaminophen...

extrapolation predicts that in the body, 2-FDCK shows a lower intrinsic hepatic clearance than ketamine. Both of these characteristics would suggest that the...

dose excreted unchanged in the urine. The greatest proportion of the hepatic clearance is by glucuronidation, followed by reduction and CYP-mediated oxidation...

greatly contributes to the hepatic clearance of drugs and other compounds. For example, cytoplasmic AOX1 a key enzyme in the hepatic phase I metabolism of...

Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of...

Biological half-life [h] Protein binding [%] Bioavailability [%] Renal/hepatic clearance [%] Food effect Daily dosage [mg] Losartan 2 98.7 33 10/90 Minimal...

"Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice". The Journal of Clinical...

that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data". European Journal of Clinical Pharmacology. 59...

PAH is used in PAH clearance to estimate renal plasma flow. The "Hepatic Extraction Ratio" is a similar measurement for clearance of a substance (usually...

risk of adverse events compared to adults, possibly due to increased hepatic clearance of the drug. The most prevalent adverse effects in children were found...

reviewed the field of vital staining, and concluded that the cells lining the hepatic sinusoids are by far the most numerous and important cells accumulating...

factors: Hepatic flow rate Cytochrome P-450 enzimatic activity Albumin affinity for the drug Extrahepatic clearance for the drug In patients with hepatic failure...

Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias...

it can inhibit lipolysis and decrease subsequent hepatic fatty acid uptake as well as inhibit hepatic secretion of VLDL; together these actions decrease...

bioavailability was calculated to be 37%, resulting in an estimated hepatic clearance of 63%. In male Wistar rats given a 5 mg/kg dose (p.o) of CP-154,526...

35.6 L/h) as having hepatic dysfunction, indicating hepatic function as the most unpredictable factor with regards to clearance variability. Patients...

in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged or abnormal...