• Thumbnail for Interleukin 1 beta
    Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and...
    26 KB (3,305 words) - 06:50, 28 March 2024
  • cytokines that mediate immune responses. Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation...
    44 KB (4,186 words) - 06:40, 13 March 2024
  • Thumbnail for Interleukin 1-alpha
    until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. IL-1α is also...
    22 KB (2,691 words) - 01:32, 15 March 2024
  • Thumbnail for Caspase 1
    Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
    21 KB (2,392 words) - 02:35, 10 March 2024
  • Thumbnail for Interleukin 1 receptor, type I
    to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor...
    10 KB (1,262 words) - 03:39, 18 February 2024
  • Thumbnail for Interleukin-1 family
    The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections...
    49 KB (6,005 words) - 11:09, 8 February 2024
  • Thumbnail for IL1RL2
    1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type...
    4 KB (603 words) - 21:06, 3 March 2023
  • Thumbnail for Caspase
    with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1). At the time, ICE was the only known caspase...
    28 KB (3,110 words) - 22:23, 25 April 2024
  • Thumbnail for Canakinumab
    antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Common side...
    15 KB (1,263 words) - 06:54, 17 March 2024
  • Thumbnail for Interleukin-1 receptor antagonist protein
    inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory...
    9 KB (1,139 words) - 14:44, 23 April 2024
  • Thumbnail for Diacerein
    osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial...
    9 KB (839 words) - 22:56, 15 February 2024
  • with several inflammatory markers, including interleukin 1 beta, interleukin 4, interleukin 6, interleukin 10, tumor necrosis factor TNFα-R2, C-reactive...
    5 KB (527 words) - 06:54, 15 August 2023
  • Thumbnail for Interleukin 8
    pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion"...
    21 KB (2,761 words) - 19:32, 11 April 2024
  • Thumbnail for Sulfonylurea
    Sulfonylureas are also used experimentally to inhibit release of interleukin 1 beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed...
    23 KB (2,571 words) - 14:42, 13 April 2024
  • Thumbnail for Interleukin 1 receptor, type II
    the signaling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by...
    11 KB (1,436 words) - 22:50, 2 April 2024
  • Thumbnail for Anthrax
    lethal factor was presumed to cause macrophages to make TNF-alpha and interleukin 1, beta (IL1B). TNF-alpha is a cytokine whose primary role is to regulate...
    93 KB (10,067 words) - 06:11, 27 April 2024
  • related to interleukin 1-beta. Both families have the same beta trefoil fold consisting of 12-stranded beta-sheet structure, with the beta-sheets are...
    25 KB (3,123 words) - 20:10, 26 April 2024
  • Thumbnail for Interleukin-12 subunit beta
    Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12...
    10 KB (1,383 words) - 03:56, 13 August 2023
  • Thumbnail for Beta trefoil fold
    the interleukin 1 cytokine family (interleukin-1 alpha, interleukin-1 beta and interleukin-1 receptor antagonist); and in fibroblast growth factors 1 and...
    2 KB (249 words) - 22:39, 6 February 2023
  • Thumbnail for Interleukin 12
    Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
    14 KB (1,578 words) - 14:00, 26 February 2024
  • Thumbnail for Methotrexate
    experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells". European Journal of Clinical...
    34 KB (3,112 words) - 09:16, 21 April 2024
  • Thumbnail for Interleukin 12 receptor, beta 1 subunit
    Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name...
    10 KB (1,291 words) - 23:01, 2 April 2024
  • Thumbnail for MPGES-1
    this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein...
    11 KB (1,131 words) - 08:24, 3 December 2023
  • to interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1 beta has...
    3 KB (211 words) - 14:21, 26 September 2023
  • Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12. It consists of beta 1 and beta 2 subunits. Chua AO, Chizzonite R, Desai...
    2 KB (156 words) - 11:50, 13 January 2024
  • Thumbnail for Duloxetine
    pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) and may increase the production...
    70 KB (7,230 words) - 18:43, 25 April 2024
  • Thumbnail for Interleukin 10
    Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
    40 KB (4,858 words) - 15:15, 9 April 2024
  • metastasis releases local cytokines including IL-6, IL-8, IL-11, interleukin-1 beta, TNF alpha and macrophage inflammatory protein. These cytokines activate...
    34 KB (3,298 words) - 03:10, 27 March 2024
  • Thumbnail for Cyclooxygenase-1
    regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha". The Journal of Biological Chemistry...
    18 KB (2,122 words) - 19:03, 27 March 2024
  • Thumbnail for Insulin-like growth factor 1
    Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in...
    39 KB (4,702 words) - 09:38, 12 March 2024