• Ionotropic GABA receptors (iGABARs) are ligand-gated ion channel of the GABA receptors class which are activated by gamma-aminobutyric acid (GABA), and...
    7 KB (687 words) - 19:31, 11 February 2023
  • Thumbnail for GABA receptor
    classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G...
    35 KB (3,884 words) - 20:11, 11 February 2024
  • γ subunits of GABA receptors to improve GABAergic signaling. Alcohol also modulates ionotropic GABA receptors. Metabotropic receptors are often G-protein-coupled...
    22 KB (2,705 words) - 08:12, 8 January 2024
  • transmission. GABA calms the brain and controls several physiological processes, such as stress, anxiety, and sleep. GABAA receptors are a class of ionotropic receptors...
    11 KB (1,274 words) - 21:20, 19 February 2024
  • Thumbnail for GABAA receptor
    The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory...
    54 KB (5,992 words) - 15:58, 28 March 2024
  • generated by lower GABA concentrations. Ionotropic glutamate receptors can include NMDA, AMPA, and kainate receptors. These receptors are named after agonists...
    26 KB (3,050 words) - 14:32, 10 September 2021
  • Thumbnail for GABA receptor agonist
    muscle relaxant effects. There are three receptors of the gamma-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that are permeable...
    8 KB (740 words) - 19:39, 11 March 2024
  • An ionotropic effect is the effect of a transmitter substance or hormone that activates or deactivates ionotropic receptors (ligand-gated ion channels)...
    1 KB (96 words) - 06:14, 27 December 2023
  • Thumbnail for Ligand-gated ion channel
    Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to...
    30 KB (2,597 words) - 04:19, 25 March 2024
  • Thumbnail for Glutamate receptor
    Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate (the conjugate base...
    63 KB (6,871 words) - 16:16, 1 February 2024
  • Thumbnail for Γ-Aminobutyric acid
    metabotropic receptors, which are G protein-coupled receptors that open or close ion channels via intermediaries (G proteins) Neurons that produce GABA as their...
    51 KB (5,563 words) - 23:57, 21 March 2024
  • Thumbnail for Kainate receptor
    Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified...
    11 KB (1,264 words) - 23:19, 4 March 2024
  • Thumbnail for Receptor (biochemistry)
    channels (ionotropic receptors) – These receptors are typically the targets of fast neurotransmitters such as acetylcholine (nicotinic) and GABA; activation...
    26 KB (2,664 words) - 00:34, 16 February 2024
  • Thumbnail for Neurotransmitter receptor
    metabotropic receptors do not have channels). There are several kinds of metabotropic receptors, including G protein-coupled receptors. Ionotropic receptors are...
    16 KB (1,590 words) - 01:49, 26 October 2023
  • to other GABAA receptors, the GABAA-ρ receptor has especially high expression in the retina. A second type of ionotropic GABA receptor, insensitive to...
    16 KB (1,639 words) - 05:16, 7 November 2023
  • Thumbnail for Glycine receptor
    The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces...
    14 KB (1,546 words) - 19:55, 4 March 2024
  • (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions as a...
    13 KB (1,191 words) - 17:00, 18 February 2024
  • Thumbnail for Nicotinic acetylcholine receptor
    the ionotropic receptors. Since nicotinic receptors help transmit outgoing signals for the sympathetic and parasympathetic systems, nicotinic receptor antagonists...
    47 KB (4,756 words) - 23:55, 26 December 2023
  • Thumbnail for GABA analogue
    acid) – GABA receptor agonist Gabamide (γ-aminobutanamide) – GABA receptor agonist Gabazine (SR-95531) – antagonist of the GABAA and GHB receptors GAVA (γ-aminopentanoic...
    8 KB (754 words) - 04:40, 27 January 2024
  • Thumbnail for Gamma-Amino-beta-hydroxybutyric acid
    anticonvulsant and is used in the treatment of epilepsy. GABOB is a GABA receptor agonist. It has two stereoisomers, and shows stereoselectivity in its...
    8 KB (688 words) - 09:14, 5 December 2023
  • Thumbnail for Glutamate (neurotransmitter)
    ctenophores have functionally distinct types of ionotropic glutamate receptors, such that activation of these receptors may trigger muscle contraction and other...
    20 KB (2,177 words) - 10:32, 5 February 2024
  • Thumbnail for Muscimol
    Muscimol (category GABAA receptor agonists)
    ncbi.nlm.nih.gov. Johnston GA (October 2014). "Muscimol as an ionotropic GABA receptor agonist". Neurochemical Research. 39 (10): 1942–1947. doi:10...
    26 KB (2,462 words) - 12:17, 23 March 2024
  • Thumbnail for Phenibut
    Phenibut (redirect from Phenyl-GABA)
    neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue. Phenibut is thought to act as a GABAB receptor agonist, similarly to baclofen and...
    31 KB (2,537 words) - 16:24, 21 March 2024
  • Thumbnail for Thujone
    Thujone (category GABAA receptor negative allosteric modulators)
    neuropharm.2003.09.022. PMID 15002407. S2CID 54346490. Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin Naser B, Bodinet C, Tegtmeier...
    27 KB (2,630 words) - 20:59, 21 March 2024
  • Thumbnail for Neurotransmitter
    interact with receptors on the target cell. The effect of the neurotransmitter is dependent on the identity of the target cell's receptors present at the...
    94 KB (8,335 words) - 06:00, 26 February 2024
  • Thumbnail for 4-Fluorophenibut
    β-(4-fluorophenyl)-GABA) is a GABAB receptor agonist which was never marketed. It is selective for the GABAB receptor over the GABAA receptor (IC50 = 1.70 μM...
    4 KB (193 words) - 16:16, 21 March 2024
  • Thumbnail for Theories of general anaesthetic action
    Letourneur, Diane; Legendre, Pascal (2021). "Electrophysiology of ionotropic GABA receptors". Cellular and Molecular Life Sciences. 78 (13): 5341–5370. doi:10...
    62 KB (6,743 words) - 16:45, 24 March 2024
  • Thumbnail for Acetylcholine receptor
    (nAChR, also known as "ionotropic" acetylcholine receptors) are particularly responsive to nicotine. The nicotine ACh receptor is also a Na+, K+ and Ca2+...
    13 KB (1,288 words) - 12:06, 30 September 2022
  • Thumbnail for Nuclear receptor
    of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription...
    74 KB (6,676 words) - 23:26, 26 December 2023
  • Thumbnail for NMDA receptor
    NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. Depending on its subunit composition...
    108 KB (12,070 words) - 02:00, 28 March 2024