{k_{12}}{k_{13}}}=1.082\pm 0.008} In physical organic chemistry, a kinetic isotope effect (KIE) is the change in the reaction rate of a chemical reaction...

the isotope is already removed in E1cBanion and leaving group departure is rate determining in E1cBrev. Another way that the kinetic isotope effect can...

Kinetic isotope effect (KIE) is a measurement of the reaction rate of isotope-labeled reactants against the more common natural substrate. Kinetic isotope...

constant#Effect of isotopic substitution Isotopic shift, effect of isotopic substitution on spectroscopy Kinetic isotope effect, effect of isotopic substitution...

the lighter and heavier isotopes and is generally modeled using transition state theory. However, in certain cases, large isotopic effects are observed that...

chemical reaction via the kinetic isotope effect. Another common application is isotopic labeling, the use of unusual isotopes as tracers or markers in...

bonds make bond cleavage reactions run more slowly, leading to the kinetic isotope effect, a well-studied concept in physical chemistry. To illustrate this...

appendices that provide technical details on molecular orbital theory, kinetic isotope effects, transition state theory, and radical chemistry.] Eric V. Anslyn...

remains the same. Thus disproportionation is weakly affected by the kinetic isotope effect with kH/kD = 1.20 ± 0.15 for ethylene. Hydrogens and deuterons are...

molecule have been replaced by its heavier stable isotope deuterium. Because of the kinetic isotope effect, deuterium-containing drugs may have significantly...

interfering effects with the typical kinetic isotope effect, allowing atypical reactions to occur with isotope-labeled molecules and demonstrating that...

several fractionating reactions with kinetic isotope effects. These reactions undergo a kinetic isotope effect because they are limited by overcoming...

The kinetic isotope effect (KIE) of ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO) is the isotopic fractionation associated solely with the...

Keystone effect (technology) Kinetic depth effect (perception) Kinetic isotope effect (chemical kinetics) (physical organic chemistry) Kirkendall effect (chemistry)...

critical for inducing this large kinetic isotope effect. The table below summarizes the reported fractionations of sulfur isotopes from MSO in different organisms...

known as a kinetic isotope effect, gives rise to isotopic differences between reactants and products that can be detected using isotope ratio mass spectrometry...

reduces and the molecule develops a lower zero point energy (see Kinetic isotope effect). The abundances of certain bonds in certain molecules are sensitive...

reaction. If the isotope is placed in the molecule at a position directly involved in the mechanism of the reaction, a kinetic isotope effect is expected....

by various chemical exchange processes, all of which exploit a kinetic isotope effect, with the partial enrichment also occurring in natural bodies of...

replaced by deuterium (or tritium). This equilibrium isotope effect is analogous to the kinetic isotope effect on rate constants, and is primarily due to the...

internal isotopic equilibrium., while freshwater microbial methanogenesis expresses large kinetic isotope effect on methane clumped isotope composition...

isotopes between the reactant and product in a chemical reaction. This is known as the kinetic isotope effect. A classic example of such an isotope effect...

comparisons between the various isotopes of hydrogen is important (as in the kinetic isotope effect or hydrogen isotopic labeling). Otherwise, referring...

the drug molecule have been replaced by deuterium. Because of the kinetic isotope effect, deuterium-containing drugs may have significantly lower rates of...

Kinetic fractionation is an isotopic fractionation process that separates stable isotopes from each other by their mass during unidirectional processes...

done in September 2010. The kinetic isotope effect, where the rate of a reaction is influenced by the presence of an isotopic atom in solution, is an important...

change when the critical hydrogen is replaced, due to a primary kinetic isotope effect, which occurs because bonds to deuterium are harder to break than...

in the DABCO catalyst. α-Deuterated acrylonitrile exhibited no kinetic isotope effect, but the product appeared to catalyze its own generation. In a model...

oxygen atoms in ozone. This is due to the kinetic isotope effect (KIE) and is caused by different isotope molecules reacting at different speeds. An...

can have observable effects on the chemical reactivity via the kinetic isotope effect, and even by extension the biological activity in some cases. Mass...