Leber congenital amaurosis (LCA) is a rare inherited eye disease that appears at birth or in the first few months of life. It affects about 1 in 40,000...

lines 25–26. Leber's congenital amaurosis (LCA) is the most severe and earliest of the inherited retinal dystrophies that cause congenital blindness. It...

virus. The CRISPR treatment for LCA10 (the most common variant of Leber congenital amaurosis which is the leading cause of inherited childhood blindness) modifies...

Amaurosis fugax (Greek: ἀμαύρωσις, amaurosis meaning 'darkening', 'dark', or 'obscure', Latin: fugax meaning 'fleeting') is a painless temporary loss of...

experimental technique. These include treatment of retinal diseases Leber's congenital amaurosis and choroideremia, X-linked SCID, ADA-SCID, adrenoleukodystrophy...

known as Leber's congenital amaurosis and Leber's hereditary optic neuropathy Titus Leber - Austrian film director Walter Philip Leber - former Panama...

Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells...

rare form of inherited blindness, known as Leber's congenital amaurosis or LCA. Leber's Congenital Amaurosis damages the light receptors in the retina...

developing countries due to financial and institutional limitations. Leber congenital amaurosis (LCA) has been a major focus in the development of gene therapy...

Windsor E. A. M.; et al. (2009). "Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year"...

eye clinic in Heidelberg. Leber was the first to describe what is now known as Leber's congenital amaurosis in 1869 and Leber's hereditary optic neuropathy...

a gene therapy medication for the treatment of Leber congenital amaurosis. Leber's congenital amaurosis, or biallelic RPE65-mediated inherited retinal...

gene therapy that is commercially available to RP patients with Leber congenital amaurosis type 2. It replaces the miscoded RPE65 protein that is produced...

epithelium cells for this conversion. A possible mechanism for Leber's congenital amaurosis has been proposed as the deficiency of RPE65. Without the RPE65...

reported that patients with the rare genetic retinal disease Leber's congenital amaurosis had been successfully treated using gene therapy with adeno-associated...

Phase 1 and Phase 2 trials for a number of diseases, including Leber's congenital amaurosis, hemophilia, congestive heart failure, spinal muscular atrophy...

clinical trial in 2017 using CRISPR gene editing techniques to treat Leber congenital amaurosis type 10 (LCA10), a rare genetic illness that causes blindness...

Albinism Aniridia Bilateral congenital cataract Bilateral optic nerve hypoplasia Idiopathic Leber's congenital amaurosis Optic nerve or macular disease...

sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis Syndromic X-linked intellectual disability Chudley-Schwartz type...

heterochromia), it is often classified as either genetic (due to mosaicism or congenital) or acquired, with mention as to whether the affected iris or portion...

associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternatively spliced transcript variants have been observed...

light on the causes of uveitis and other autoimmune diseases. Leber congenital amaurosis is a rare inherited eye disease that impairs vision starting in...

Congenital cataracts are a lens opacity that is present at birth. Congenital cataracts occur in a broad range of severity. Some lens opacities do not progress...

including achromatopsia, cone dystrophy, Leber's congenital amaurosis and retinitis pigmentosa. These can be congenital or commence in childhood or adulthood...

eventually require extra-ocular muscle surgery to resolve their problems. Congenital esotropia, or infantile esotropia, is a specific sub-type of primary concomitant...

glasses and colored halos due to hydration of lens.[citation needed] Congenital cataracts can result in amblyopia if not treated in a timely manner. Age...

Congenital red–green color blindness is an inherited condition that is the root cause of the majority of cases of color blindness. It has no significant...

conjunctivitis), retinoblastoma, and congenital conditions (cataracts and glaucoma). Leber congenital amaurosis primarily affects the retina, and typically...

needed] Aphakia Blepharitis Buphthalmos Cataracts Coloboma Cone dystrophy Congenital abnormalities of the eye Viral conjunctivitis Corneal abrasion Corneal...

genotyping reveals RPE65 as the most frequently mutated gene in Leber congenital amaurosis in Denmark". European Journal of Human Genetics. 24 (7): 1071–1079...