Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a...

used in clinical and research settings, pioneering lentivirals vector in gene therapy. Jesse Gelsinger's death in 1999 impeded gene therapy research in the...

onset of tumors in a mouse strain prone to tumors. Moreover, clinical trials that utilized lentiviral vectors to deliver gene therapy for the treatment...

Gene therapy using lentiviral vectors was being explored in early stage trials as of 2009.[needs update] In a Phase I clinical trial of three patients...

express a specific CAR, using a vector derived from an engineered lentivirus such as HIV (see Lentiviral vector in gene therapy). The CAR programs the T cells...

hosts, and extended gene expression. Lentiviral vectors have also shown promise. Among challenges to clinical translation of gene therapy are possible immune...

(2014). "Long-term safety and tolerability of Pro Savin, a lentiviral vector-based gene therapy for Parkinson's disease: A dose escalation, open-label, phase...

organism. Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and...

platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has advantages over other gene-therapy methods including high-efficiency...

"Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs". Molecular Therapy. 8 (2): 196–206. doi:10.1016/s1525-0016(03)00165-5...

ancestor at > 450 million years ago. Gammaretroviral and lentiviral vectors for gene therapy have been developed that mediate stable genetic modification...

Emmanuel (February 2016). "Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β – Gene". Human Gene Therapy. 27 (2): 148–165. doi:10...

mutagenesis Poletti, Valentina; Mavilio, Fulvio (2021). "Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases". Viruses. 13 (8): 5. doi:10.3390/v13081526...

regulation of disease-related genes may enable novel therapies for many diseases, especially in cases where adequate gene therapies are not yet developed or...

retroviral and lentiviral vectors for gene therapy, allows it to be used for downstream purification of viral vectors. Heparin is being trialed in a nasal spray...

therapy for sickle cell disease in humans were started in 2014. The clinical trials assessed the safety of lentiviral vector-modified bone marrow for adults...

Naldini L (November 2007). "Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery". Nature Biotechnology...

development of lentiviral vectors for gene therapy. Trono obtained an M.D. from the University of Geneva in 1982 and completed a clinical training in internal...

2009). "State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations". Current Gene Therapy. 9 (6): 459–74. doi:10...

acknowledged specialist in HIV, lentiviral gene transfer vectors, and their medical applications. His discovery of the central DNA-flap structure in the HIV genome...

virus or viral vector. An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. Transduction...

named icasM28z. In 2013, Sadelain co-founded Juno Therapeutics Inc. Sadelain also designed lentiviral vectors encoding the β-globin gene for the treatment...

Morton J.; Sorrentino, Brian P. (18 April 2019). "Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1". New England Journal of...

and gene therapy. She has designed clinical trials based on lentiviral vector in gene therapy and pioneered the use of haematopoietic stem cell gene therapy...

HIV-1, FIV has been engineered into a viral vector for gene therapy. Like other lentiviral vectors, FIV vectors integrate into the chromosome of the host...

Interfering RNA Delivery". Nonviral Vectors for Gene Therapy - Lipid- and Polymer-based Gene Transfer. Advances in Genetics. Vol. 88. pp. 71–110. doi:10...

Morris KV, Rossi JJ (March 2006). "Lentiviral-mediated delivery of siRNAs for antiviral therapy". Gene Therapy. 13 (6): 553–8. doi:10.1038/sj.gt.3302688...

methods because they can transfer genes into a wide variety of human cells and have high transfer rates. Lentiviral vectors are also helpful due to their...

safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease" (PDF). Current Gene Therapy. 15 (1): 64–81. doi:10...

"Improved lentiviral vectors for Wiskott–Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis". Gene Therapy. 15 (12):...