Beloranib (category METAP2 inhibitors) METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer. However, once the potential anti-obesity effects of METAP2 inhibition... 7 KB (482 words) - 04:51, 14 October 2023 |
Pharmaceuticals worked together to assess the efficacy and quality of Asieris's MetAP2 inhibitor and BeiGene's PD-L1 inhibitor for bladder cancer patients. Novartis... 26 KB (2,448 words) - 04:09, 9 April 2024 |
P08581 9472 METAP1 HGNC:15789 P53582 9473 METAP1D HGNC:32583 Q6UB28 9474 METAP2 HGNC:16672 P50579 9475 METRN HGNC:14151 Q9UJH8 9476 METRNL HGNC:27584 Q641Q3... 277 KB (17 words) - 23:17, 27 April 2024 |
shown to have antiangiogenic properties. For example, nitroxoline inhibits MetAP2 activity, an enzyme associated with angiogenesis, and HUVEC proliferation... 10 KB (1,079 words) - 14:46, 5 May 2024 |
and eukaryotes. Human proteins possessing this activity include METAP1, METAP2, METAP1D (mitochondrial), and RNPEPL1. Yoshida A, Lin M (1972). "NH2-terminal... 3 KB (251 words) - 09:31, 2 January 2024 |
TNP-470 (category METAP2 inhibitors) TNP-470 is an methionine aminopeptidase 2 inhibitor. Although it was one of the first angiogenesis inhibitor tested in clinical trials, its potential was... 3 KB (167 words) - 04:50, 8 November 2023 |
ZGN-1061 (category METAP2 inhibitors) ZGN-1061 is an experimental drug that was developed by Zafgen for treatment of obesity and type 2 diabetes. It has a similar mechanism of action as the... 3 KB (190 words) - 22:04, 6 March 2024 |