• Thumbnail for METAP2
    Methionine aminopeptidase 2 is an enzyme that in humans is encoded by the METAP2 gene. Methionine aminopeptidase 2, a member of the dimetallohydrolase family...
    27 KB (3,068 words) - 17:32, 22 April 2024
  • Thumbnail for Beloranib
    Beloranib (category METAP2 inhibitors)
    METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer. However, once the potential anti-obesity effects of METAP2 inhibition...
    7 KB (482 words) - 04:51, 14 October 2023
  • Pharmaceuticals worked together to assess the efficacy and quality of Asieris's MetAP2 inhibitor and BeiGene's PD-L1 inhibitor for bladder cancer patients. Novartis...
    26 KB (2,448 words) - 04:09, 9 April 2024
  • P08581 9472 METAP1 HGNC:15789 P53582 9473 METAP1D HGNC:32583 Q6UB28 9474 METAP2 HGNC:16672 P50579 9475 METRN HGNC:14151 Q9UJH8 9476 METRNL HGNC:27584 Q641Q3...
    277 KB (17 words) - 23:17, 27 April 2024
  • Thumbnail for Fumarranol
    which acts as an inhibitor of the type 2 methionine aminopeptidase enzyme METAP2. It was derived by structural modification of the natural product fumagillin...
    2 KB (188 words) - 10:51, 29 November 2023
  • Thumbnail for Nitroxoline
    shown to have antiangiogenic properties. For example, nitroxoline inhibits MetAP2 activity, an enzyme associated with angiogenesis, and HUVEC proliferation...
    10 KB (1,079 words) - 14:46, 5 May 2024
  • and eukaryotes. Human proteins possessing this activity include METAP1, METAP2, METAP1D (mitochondrial), and RNPEPL1. Yoshida A, Lin M (1972). "NH2-terminal...
    3 KB (251 words) - 09:31, 2 January 2024
  • Thumbnail for TNP-470
    TNP-470 (category METAP2 inhibitors)
    TNP-470 is an methionine aminopeptidase 2 inhibitor. Although it was one of the first angiogenesis inhibitor tested in clinical trials, its potential was...
    3 KB (167 words) - 04:50, 8 November 2023
  • Thumbnail for Stress granule
    replication licensing factor MCM7 yes METAP1 METAP1 Methionine aminopeptidase METAP2 METAP2 Methionyl Aminopeptidase 2 MCRIP1 FAM195B/GRAN2 Granulin-2 MCRIP2 FAM195A/GRAN1...
    184 KB (12,548 words) - 05:28, 27 April 2024
  • Thumbnail for ZGN-1061
    ZGN-1061 (category METAP2 inhibitors)
    ZGN-1061 is an experimental drug that was developed by Zafgen for treatment of obesity and type 2 diabetes. It has a similar mechanism of action as the...
    3 KB (190 words) - 22:04, 6 March 2024
  • Thumbnail for Protein kinase R
    Protein kinase R has been shown to interact with: ASK1, DNAJC3, ILF3, METAP2, P53, PPP1CA, PRKRA, STAT1, and TARBP2. GRCh38: Ensembl release 89: ENSG00000055332...
    36 KB (4,105 words) - 14:32, 21 December 2023