Mister Sinister (Dr. Nathaniel Essex) is a supervillain appearing in American comic books published by Marvel Comics. Created by writer Chris Claremont...

included mutant warriors and assassins employed by the X-Men's enemy Mister Sinister, a mad scientist villain often intent on creating a perfect race of...

actually a front for Mister Sinister's genetic laboratory. Mister Sinister appears and tells Madelyne about her origins. When Mister Sinister learned about Jean...

Bar Sinister, though not part of Krakoa, was added to its landmass with Flowers of Krakoa that modify the former secret base of Mister Sinister into...

voices Madelyne Pryor / Goblin Queen, a mutant clone of Jean created by Mister Sinister. Madelyne gives birth to Cyclops's son, Nathan, which further complicates...

team, a group of mutants who often work for the mad scientist villain Mister Sinister. As a Marauder, she has often fought the X-Men as well as related teams...

wife Rogue. This was exacerbated when Gambit's connections to villain Mister Sinister were revealed, although some of his team members accept that Gambit...

Alamogordo genetics plant in Las Cruces, New Mexico by Mister Sinister. In the past Sinister had worked here (disguised as a Dr. Milbury) alongside Brian...

the show's premiere. The second-season premiere would reveal that Mister Sinister found Morph's body, resurrecting and experimenting on him, turning...

which he uses for advice. When Dark Beast asks for Mister Sinister to let him out, Mister Sinister informs him that he's not the "darkest beast" anymore...

working with the Marauders and for Mister Sinister. Mystique shoots Rogue and takes her back to Mister Sinister's base, who only keeps Rogue alive because...

the council about Doctor Statis, Mister Sinister's clone claiming to be the real Sinister, causing Mister Sinister to flee only to be captured briefly...

brought about by Mister Sinister's corrupt machinations and his experiment in creating a batch of Mutants called Chimeras. Sins of Sinister kick-offed with...

with Jean and starts to be friendly towards Madelyne Pryor due to Mister Sinister switching the two. Wolverine / Logan (voiced by Cathal J. Dodd in both...

 45. The Uncanny X-Men #236 Burnett, Andrew (2009). "Mad Genetics: The Sinister Side of Biological Mastery". In Housel, Rebecca; Wisnewski, J. Jeremy (eds...

and Danielle discovered that the head of the Weapon X facility is Mister Sinister who created the Sabretooth clones and claimed that he orchestrated...

about it, Mister Sinister is undeterred in his next plans to research the Chimeras. Later in the "Sins of Sinister" storyline, Mister Sinister was in an...

superhuman being Mister Sinister. He then coerces Sinister and the Hellfire Club into aiding his plans for global conquest, but Sinister concludes that...

left-handedness Sinister, a stagename of bassist Derrick Tribbett's Mister Sinister, Marvel Comics supervillain Simon Bar Sinister, villain on the Underdog...

Apocalypse 10th anniversary limited series, Mister Sinister assembles his own group dubbed the Sinister Six. However, this group is unrelated to the...

featuring the reveal of Jon Hamm as the villain Nathaniel Essex / Mister Sinister, Fox requested the reshoots to include a new post-credits scene introducing...

leads Jean Grey, Mister Sinister, Wolverine, Ajak, Sersi, and Makkari into the Progenitor. After Iron Man mentions to Mister Sinister that the Progenitor...

Apocalypse 10th anniversary limited series, Mister Sinister assembles his own group dubbed the Sinister Six to fight Magneto's X-Men. However, this group...

created by Bastion through OZT with the aid of Mister Sinister. Human subjects were injected with Sinister's Techno-Organic Virus, transforming them into...

Iron Man in fighting Mister Sinister, slicing off Mister Sinister's left hand. Iron Man finds information in Mister Sinister's database which reveals that...

In the second season, Cyclops and Jean are married and targeted by Mister Sinister, who seeks to use the genetically perfect combination of their DNA...

Pryor—mother of his son Cable—and X-Man Emma Frost. Cyclops' archenemy is Mister Sinister, who has often manipulated events in his life and is obsessed with...

of the mutant assassin team known as Marauders, who are employed by Mister Sinister. Little is known about Harpoon other than that he is Inuit. Harpoon...

still alive, so, with the help of Emma, he seeks out Mister Sinister. The X-Men and Mister Sinister have a confrontation that does not result in them finding...

Colossus, Nightcrawler, and Wolverine. Returning to Mister Sinister with the samples, Mister Sinister tells him that he planned to clone a new generation...