A Morpholino, also known as a Morpholino oligomer and as a phosphorodiamidate Morpholino oligomer (PMO), is a type of oligomer molecule (colloquially,...

2-morpholinoethanesulfonic acid; 2-(4-morpholino)ethanesulfonic acid; 2-(N-morpholino)ethanesulfonic acid; 2-(4-morpholino)ethanesulfonic acid; MES; MES hydrate;...

MOPS (3-(N-morpholino)propanesulfonic acid) is a buffer introduced in the 1960s, one of the twenty Good's buffers. It is a structural analog to MES, and...

(snRNPs) to pre-mRNA using Morpholino antisense oligos. This has become a standard technique in developmental biology. Morpholino oligos can also be targeted...

N-Nonanoylmorpholine, 1-(4-Morpholino)-1-nonanone, 4-Morpholinenonylic acid, Pelargonic acid morpholide, Pelargonic morpholide, N-Morpholino nonanamide,...

biochemistries. Artificial nucleic acids include peptide nucleic acids (PNA), Morpholino and locked nucleic acids (LNA), as well as glycol nucleic acids (GNA)...

purpose include phosphorothioate, 2'-O-methyl, morpholino, MEA phosphoramidate and DEED phosphoramidate. Morpholino oligos are used in both X. laevis and X....

a morpholino oligomer binds to messenger RNA produced by a known disease-causing gene to prevent it from being translated into protein. Morpholinos can...

An organism which has been treated with a morpholino antisense oligo to temporarily knock down expression of a targeted gene is called a morphant. This...

have been designed and synthesized. They include peptide nucleic acid, morpholino- and locked nucleic acid, glycol nucleic acid, and threose nucleic acid...

isoborneol are used as ligands in asymmetric synthesis. (2S)-(−)-3-exo-(morpholino)isoborneol or MIB with a morpholine substituent in the α-hydroxyl position...

application results in 80-95% down-regulation of mRNA expression. The use of Morpholino antisense oligonucleotides for gene knockdowns in vertebrates, which is...

is to reduce gene expression or modify splicing using Morpholino antisense technology. Morpholino oligonucleotides (MO) are stable, synthetic macromolecules...

structural type that has proven especially valuable in research is morpholino antisense. Morpholino oligos have been used to experimentally suppress many viral...

propan-2-yl]amino]ethanesulfonic acid) 7.40 −0.020 229.20 MOPS, (3-(N-morpholino)propanesulfonic acid) 7.20 −0.015 209.3 PIPES, (piperazine-N,N′-bis(2-ethanesulfonic...

can be blocked or splicing of pre-mRNA can be modified by injection of Morpholino antisense oligos into the oocyte (for distribution throughout the embryo)...

in August 1998, as a treatment for cytomegalovirus retinitis. Several morpholino oligos have been approved to treat specific groups of mutations causing...

governments Former Movement of Socialist Left, Portugal MES (buffer), 2-(N-morpholino)ethanesulfonic acid Mesityl group (Mes) in Mesitylene Manufacturing execution...

manufactures Morpholino antisense oligos and delivery reagents. Gene Tools was founded in 1997 and began regularly shipping custom-sequence Morpholino oligos...

Dextromoramide (d-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine) Diphenylmorpholinoisovaleric acid (2-methyl-3-morpholino-1,1-diphenylpropionic acid)...

 108. Chen YK, Jeon SJ, Walsh PJ, Nugent WA (2005). "(2S)-(−)-3-exo-(Morpholino)isoborneol ((−)-MIB)". Organic Syntheses. 82: 87. Smith WB, Ho OC (1990)...

Cardiac problems may require a pacemaker. The medication eteplirsen, a Morpholino antisense oligo, has been approved in the United States for the treatment...

attempted. The use of Morpholinos has also been attempted in mice and cell cultures in order to reduce progerin production. Antisense Morpholino oligonucleotides...

(3-methyl-4-morpholin-4-yl-2,2-diphenylbutanoic acid, on INCB Yellow List as 2-methyl-3-morpholino-1,1-diphenylpropane carboxylic acid) is a moramide precursor scheduled...

fragments of analogs of nucleic acids such as peptide nucleic acid or Morpholinos. The units of an oligomer may be connected by covalent bonds, which may...

glucocorticoid (e.g. dexamethasone or prednisone). Mycophenolate mofetil is the morpholino‌ ethyl ester of mycophenolic acid; the ester masks the carboxyl group...

organosilica, a type of silica containing organic groups Phosphorodiamidate morpholino oligo, a type of molecule in molecular biology Planetary-mass object,...

RISC complex) a simple alternative for gene knockdown is Morpholino antisense oligos. Morpholinos bind and block access to the target mRNA without requiring...

pp. 13–. ISBN 978-0-203-64196-5. FR 2199M, "N-morpholino-1 n-phénylisopropylamino-2 éthane [N-morpholino-1 N-phenylisopropylamino-2 ethane]", published...

oligonucleotides. Their work demonstrated the efficacy of phosphorodiamidate morpholino oligomers (PMOs) as splice-switching agents. Their efforts culminated...