Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...

cells to inhibit muscle growth. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. Myostatin is assembled...

1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular...

Creatine (/ˈkriːətiːn/ or /ˈkriːətɪn/) is an organic compound with the nominal formula (H2N)(HN)CN(CH3)CH2CO2H. It exists in various tautomers in solutions...

Hasegawa Y, et al. (February 2008). "Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates...

Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...

activin type 2 receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested preliminarily in humans in the...

plays a role in non-MSI-H colorectal cancers. Stamulumab (MYO-029) myostatin Inhibitor Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN,...

of Medicine. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis". Biochemical...

; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...

PMID 23995658. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis". Biochemical...

prevent Axl activation. ACE-031 is an engineered decoy receptor and myostatin inhibitor used in attempts to treat children with Duchenne muscular dystrophy...

Garetosmab is a fully human, experimental monoclonal antibody against activin-A. It has been tried in patients with fibrodysplasia ossificans progressiva...

including clomiphene, cyclofenil, and fulvestrant Myostatin modifying agents, including myostatin inhibitors (e.g., follistatin) Metabolic modifying agents...

beta chain thromboembolism (diagnosis) Bimagrumab mab human ACVR2B myostatin inhibitor Bimekizumab Bimzelx mab humanized IL-17A, IL-17F, IL-17AF Y psoriasis...

the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that inhibits muscle...

et al. (June 2018). "Effects of bimagrumab, an activin receptor type II inhibitor, on pituitary neurohormonal axes". Clinical Endocrinology. 88 (6): 908–919...

fulvestrant, and all other anti-estrogenic substances are banned. Myostatin inhibitors are banned. Metabolic modulators including peroxisome proliferator-activated...

A.; Liu, Yewei; Germain-Lee, Emily L. (22 September 2020). "Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight"...

"Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin...

effects. Myocytes use myostatin to tell each other to inhibit myogenesis. Melanocyte-inhibiting factor (melanostatin) inhibits release of other neuropeptides...

Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from...

activin type 2 receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested preliminarily in humans in the...

mice after chronic training. Because decorin directly binds myostatin, a potent inhibitor of muscle growth, we investigated a potential function of decorin...

SB-431542 and A83-01 inhibit TGFβRI/ALK5 and the type I receptor ALK4/7. Galunisertib is the selective and potent TGFβRI kinase inhibitor. The parasitic roundworm...

GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors, ALK5, ALK4 and ALK7. However, it is not an inhibitor of anaplastic lymphoma...

alfa Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288 ALK4 (ACVR1B) Agonists: Activin (A, B, AB) GDF (1, 3, 11 (BMP11)) Myostatin (GDF8) Nodal...

(2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of...

homologue, antivin, in zebrafish show that Lefty likely acts as a competitive inhibitor of Nodal signaling. Overexpression of Lefty leads to a phenotype similar...

endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916;...