Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...

An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...

gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and...

Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform. The orexinergic nucleus in the lateral hypothalamus is...

clinically characterized by symptoms of EDS and cataplexy, and/or will have CSF orexin levels of less than 110 pg/ml. Cataplexy are transient episodes of aberrant...

(e.g., anandamide) and the orexin neuropeptides orexin-A and orexin-B are the primary signaling neurochemicals in orexin neurons; pathway-specific neurochemicals...

Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...

Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken...

colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1...

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...

Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. The...

Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...

neuronal orexin producing cells located in the lateral hypothalamus and a decrease in orexin concentrations in the cerebral spinal fluid. Normally, orexin acts...

and associate with arousal. Orexin deficiency has been identified as responsible for narcolepsy. Research suggests that orexin and histamine neurons play...

hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition...

homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo-...

least some catabolic effects have been discovered, including cytokines, orexin (known as hypocretin), and melatonin.[citation needed] The word catabolism...

an orexin antagonist medication which is under development for the treatment of depression and insomnia. It is a selective antagonist of the orexin OX2...

Danavorexton (developmental code name TAK-925) is a selective orexin 2 receptor agonist. It is a small-molecule compound and is administered intravenously...

940) Fluorafinil (CRL-40,941) Fluorenol Methylbisfluoromodafinil Selective orexin receptor agonists (two are currently under development by Takeda, danavorexton...

sensed by glucose-inhibited neurons in the lateral hypothalamus. These orexin-expressing neurons appear to be hyperpolarised (inhibited) by a glucose-activated...

"Chapter 6: Widely Projecting Systems: Monoamines, Acetylcholine, and Orexin". In Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation...

(8–9): 405–11. doi:10.1016/j.mad.2011.06.005. PMC 3367503. PMID 21729715. Orexin receptor antagonists a new class of sleeping pill, National Sleep Foundation...

hedonic coldspot. In rats, microinjections of opioids, endocannabinoids, and orexin are capable of enhancing liking reactions in these hotspots. The hedonic...

agonist Clonidine Guanfacine Cannabinoids Cannabidiol Tetrahydrocannabinol Orexin receptor antagonist Suvorexant Lemborexant Daridorexant Gabapentinoids Gabapentin...

abstract). In specific subregions of each area, either opioid-stimulating or orexin-stimulating microinjections appear to enhance the number of liking reactions...

antidepressants and antihistamines, quetiapine, orexin receptor antagonists, and melatonin receptor agonists, the orexin antagonist lemborexant and the Z-drug eszopiclone...

ramelteon. Dual orexin receptor antagonists are drugs that block the orexin receptors OX1 and OX2, hence reducing the wakeful effect of the orexin system and...

increased orexin in the perifornical lateral hypothalamus (PFLH). In the high triglyceride rats, they greater expression in the PVN but reduced orexin in the...

interaction. MCH and the hormone orexin have an antagonistic relationship with one another with regards to the sleep cycle, with orexin being almost entirely active...