mechanosensitive ion channel component 2 is a protein that in humans is encoded by the PIEZO2 gene. It has a homotrimeric structure, with three blades curving into a...

Armenian descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian...

close homolog PIEZO2 were cloned in 2010, using an siRNA-based screen for mechanosensitive ion channels. PIEZO1 (this gene) and PIEZO2 share 47% identity...

system. Merkel cells express PIEZO2, a mechanosensitive ion channel that responds to mechanical forces. Mice in which Piezo2 is knocked-out specifically...

in the PIEZO2 gene exhibit specific deficits in joint proprioception, as well as vibration and touch discrimination, suggesting that the PIEZO2 channel...

excitatory signals via ion conductance on mechanosensitive channels. of which Piezo2 is the Merkel cell's primary mechanosensor. The Merkel cell's somewhat rigid...

mechanosensitivity is hypothesised to be linked to the expression of PIEZO1 and PIEZO2 on neurons in the petrosal and nodose ganglia. Baroreceptor action potentials...

News. Jan 1, 2010. Retrieved 3 January 2010. "Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage"...

for [i.a.] temperature and touch [the discovery/mechanics of TRPV1 and PIEZO2] Nobel Prize in Physics – Syukuro Manabe and Klaus Hasselmann (1/2) "for...

markers synaptophysin and chromogranin A. Furthermore, the ion channel Piezo2 and transcription factor Atoh1, both specific to Merkel cells, are also...

Gordon syndrome is a rare autosomal dominant disorder caused by mutation in PIEZO2. It affects males and females equally. Fewer than 50 cases have been reported...

Nobel Prize laureate known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors William W. Parmley – Former Editor of the Journal of...

Earley T.J., Ranade S., Petrus M.J., Dubin A.E., Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels...

L2-3 SST NMU unknown unknown brain None None unknown None HPSE2, NOS1, PIEZO2 Inh L2-5 PVALB HHIPL1 unknown unknown brain None None unknown None ADAMTS17...

Q5BN46 12123 PIERCE2 HGNC:44654 H3BRN8 12124 PIEZO1 HGNC:28993 Q92508 12125 PIEZO2 HGNC:26270 Q9H5I5 12126 PIF1 HGNC:26220 Q9H611 12127 PIGA HGNC:8957 P37287...

151050 PTDSS1 Lissencephaly 3 611603 TUBA1A Marden–Walker syndrome 248700 PIEZO2 MASA syndrome 303350 L1CAM Microhydranencephaly 605013 NDE1 Mowat–Wilson...

Farshid; Liedtke, Wolfgang B. (2014-11-25). "Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage"...

channels and the recently cloned cation selective PIEZO family (PIEZO1 and PIEZO2). MSCs can be classified based on the type of ion to which they are permeable:...

suggests INAVA may interact with the following proteins: DNAJC5G, SLC7A13, PIEZO2, MUC19. Experimental evidence, from a yeast two hybrid screen, suggests...

Torres JM, Bee L, Dickenson AH, Gringhuis M, et al. (2013). "A role for Piezo2 in EPAC1-dependent mechanical allodynia". Nature Communications. 4: 1682...