• Thumbnail for PTPN22
    Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine...
    33 KB (3,898 words) - 01:12, 11 November 2023
  • Thumbnail for Allergic rhinitis
    that certain SNPs in the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene can...
    50 KB (5,347 words) - 08:37, 7 December 2023
  • Thumbnail for Uveitis
    genetic factors that predispose disease onset including HLA-B27 and the PTPN22 genotype. Recent evidence has pointed to reactivation of herpes simplex...
    31 KB (3,207 words) - 22:21, 10 January 2024
  • Thumbnail for Autoimmunity
    of susceptibility to lupus erythematosus). In recent studies, the gene PTPN22 has emerged as a significant factor linked to various autoimmune diseases...
    50 KB (5,851 words) - 17:14, 9 May 2024
  • Thumbnail for Hashimoto's thyroiditis
    analysis. CTLA-4 was confirmed as the main locus for thyroid autoantibodies. PTPN22 is the most recently identified immune-regulatory gene associated with autoimmune...
    69 KB (7,744 words) - 11:35, 30 April 2024
  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype showed significant association with anti-topo I. The...
    9 KB (870 words) - 02:13, 3 December 2023
  • Thumbnail for Granulomatosis with polyangiitis
    people with GPA. Several genes involved in the immune system including PTPN22, CTLA4, and human leukocyte antigen genes may influence the risk of developing...
    30 KB (3,162 words) - 05:26, 13 March 2024
  • Thumbnail for Rheumatoid arthritis
    CD40, cytokine signaling, lymphocyte receptor activation threshold (e.g., PTPN22), and innate immune activation—appear to have less influence than HLA mutations...
    147 KB (17,107 words) - 16:55, 9 May 2024
  • Thumbnail for Tyrosine-protein kinase CSK
    phosphatase ("Lyp", gene product of PTPN22) is possibly associated with the increased autoimmune diseases associated with PTPN22 mutations. GRCh38: Ensembl release...
    8 KB (977 words) - 00:09, 6 October 2021
  • Thumbnail for Lupus
    risk of SLE. Other genes which contain risk variants for SLE are IRF5, PTPN22, STAT4, CDKN1A, ITGAM, BLK, OX40L and BANK1. Some of the susceptibility...
    119 KB (13,041 words) - 15:18, 1 May 2024
  • Thumbnail for Graves' disease
    thyrotropin receptor, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), and cytotoxic T-lymphocyte–associated antigen 4, among others. Since Graves'...
    62 KB (6,414 words) - 05:52, 1 March 2024
  • Thumbnail for 25-Hydroxyvitamin D 1-alpha-hydroxylase
    Smith KG (2009). "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis". BMC Medical Genetics. 10: 121. doi:10...
    13 KB (1,499 words) - 00:11, 30 November 2023
  • Thumbnail for Cytotoxic T-lymphocyte associated protein 4
    PMID 15132716. Brand O, Gough S, Heward J (October 2005). "HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?". Expert Reviews in Molecular...
    30 KB (3,464 words) - 19:11, 5 May 2024
  • Q99952 13140 PTPN20 HGNC:23423 Q4JDL3 13141 PTPN21 HGNC:9651 Q16825 13142 PTPN22 HGNC:9652 Q9Y2R2 13143 PTPN23 HGNC:14406 Q9H3S7 13144 PTPRA HGNC:9664 P18433...
    282 KB (17 words) - 23:17, 27 April 2024
  • Thumbnail for Shapiro–Senapathy algorithm
    cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e...
    69 KB (6,804 words) - 04:42, 27 April 2024
  • Thumbnail for PADI4
    samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4". American Journal of Human Genetics. 77 (6): 1044–1060...
    11 KB (1,214 words) - 07:58, 3 December 2023
  • Prajapati, Hiral; Marfatia, Y.S.; Begum, Rasheedunnisa (2008). "Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population"...
    33 KB (3,976 words) - 05:46, 23 October 2023
  • Thumbnail for Lars Klareskog
    et al.: Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis, American J. Hum. Genetics...
    5 KB (587 words) - 16:26, 26 November 2023
  • Thumbnail for N-Acylethanolamine
    followed by conversion of pAEA into NAE 20:4 (AEA) by phosphatases such as PTPN22 and SHIP1. The effects of NAE 20:4 (AEA) and another endocannabinoid...
    185 KB (20,234 words) - 08:56, 16 April 2024
  • Thumbnail for CXorf66
    4 + 107146630 107147268 USP48 84196 241 631 89.0% 1 + 22014725 22015355 PTPN22 26191 227 281 90.0% 1 - 114365307 114365587 PSPH 5723 220 605 90.6% 7 -...
    20 KB (1,689 words) - 05:55, 10 March 2024
  • Thumbnail for FCRL3
    arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis and Rheumatism...
    16 KB (1,917 words) - 08:11, 27 March 2024