• Thumbnail for Platelet
    as more than 193 proteins and 301 interactions are known to be involved in platelet dynamics. While there is much overlap, platelet function can be modeled...
    70 KB (8,489 words) - 19:46, 26 March 2024
  • Thumbnail for Coagulation
    D. R. (25 July 1987). "Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix"...
    60 KB (5,909 words) - 15:49, 16 March 2024
  • Thumbnail for Liver disease
    tendency: coagulation factor VIII and von Willebrand factor, a platelet adhesive protein. Both inversely rise in the setting of hepatic insufficiency,...
    29 KB (2,825 words) - 07:05, 10 March 2024
  • While platelet membranes have binding sites for fibrinogen, they must be induced by thrombin. Thrombin triggers the binding of the adhesive platelets with...
    9 KB (1,278 words) - 22:10, 30 October 2023
  • Thumbnail for Thrombospondin 1
    protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin...
    17 KB (2,125 words) - 00:35, 19 February 2024
  • Thumbnail for Multimerin 1
    V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently...
    8 KB (899 words) - 09:53, 27 January 2024
  • Thumbnail for Nacre
    organic matrix than going straight into another aragonite platelet. This results in the ductile protein phase deforming such that the crack changes directions...
    36 KB (3,894 words) - 03:30, 25 February 2024
  • Thumbnail for Arginylglycylaspartic acid
    fibrinogen, vitronectin, osteopontin, and several other adhesive extracellular matrix proteins. The discovery of RGD and elucidation of how RGD binds to...
    36 KB (3,744 words) - 15:44, 15 March 2024
  • Thumbnail for Dense granule
    Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak...
    8 KB (998 words) - 02:13, 11 June 2023
  • Thumbnail for Extracellular matrix
    binding to platelets during blood clotting and facilitating cell movement to the affected area during wound healing. Laminins are proteins found in the...
    36 KB (4,086 words) - 05:30, 9 March 2024
  • Thumbnail for Osteonectin
    fibroblasts, synthesize osteonectin. This protein is synthesized by macrophages at sites of wound repair and platelet degranulation, so it may play an important...
    13 KB (1,629 words) - 03:30, 26 March 2024
  • Thumbnail for Biopolymer
    has a lower tensile strength but has strong adhesive properties due to its insoluble and fibrous protein composition. In recent studies, silk fibroin...
    24 KB (3,042 words) - 07:57, 17 March 2024
  • Thumbnail for Dextran
    erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. Dextrans...
    13 KB (1,344 words) - 19:40, 31 December 2023
  • Thumbnail for Collagen
    Collagen (category Structural proteins)
    Collagen (/ˈkɒlədʒən/) is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component...
    64 KB (6,885 words) - 19:07, 6 March 2024
  • Thumbnail for Glycoprotein IX
    Glycoprotein IX (category Membrane protein stubs)
    PMID 2557900. Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank...
    8 KB (1,082 words) - 20:16, 23 December 2023
  • Thumbnail for GP1BB
    Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c (Cluster of Differentiation 42c), is a protein that in humans is encoded by the...
    11 KB (1,402 words) - 15:13, 3 December 2023
  • arteries, which are composed of LDL and assorted other debris (including platelets). Broken pieces of those deposits or closure of the arterial opening can...
    115 KB (14,928 words) - 21:42, 31 December 2023
  • Thumbnail for Fibrosis
    called interstitium. Other soluble mediators of fibrosis include CTGF, platelet-derived growth factor (PDGF), and interleukin 10 (IL-10). These initiate...
    13 KB (1,383 words) - 04:19, 25 March 2024
  • macrophages, lymphocytes, neutrophils, mast cells, dendritic cells and platelets, create an inflammatory environment in the synovium, attract more immune...
    7 KB (863 words) - 04:59, 9 December 2023
  • coagulation. Heparin has been shown to suppress platelet adhesion, complement activation and protein adsorption. Advanced polymer composites are used...
    23 KB (3,145 words) - 22:57, 28 July 2023
  • Thumbnail for Streptavidin
    Streptavidin (category Protein articles without symbol)
    Streptavidin /ˌstrɛpˈtævɪdɪn/ is a 52 kDa protein (tetramer) purified from the bacterium Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily...
    20 KB (2,487 words) - 20:35, 13 August 2023
  • Thumbnail for Exosome (vesicle)
    effective drug carriers. Composed of cellular membranes with multiple adhesive proteins on their surface, exosomes are known to specialize in cell–cell communications...
    67 KB (7,600 words) - 06:04, 11 March 2024
  • Thumbnail for Leukocyte extravasation
    Marshall-Carlson L, Bainton DF (July 1989). "GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and...
    27 KB (3,303 words) - 08:08, 21 March 2024
  • Thumbnail for CYR61
    matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN...
    41 KB (4,894 words) - 09:33, 2 January 2024
  • Thumbnail for OSGEP
    Vickers JD, Packham MA, Kinlough-Rathbone RL (1997). "Differences between platelet phosphoinositide metabolism stimulated by thrombin or SFLLRN are not accounted...
    6 KB (561 words) - 18:35, 19 January 2024
  • Thumbnail for Neisseria meningitidis
    other possible causes, such as idiopathic thrombocytopenic purpura (ITP; a platelet disorder) and Henoch–Schönlein purpura, also need prompt investigation...
    41 KB (4,629 words) - 17:24, 22 February 2024
  • Thumbnail for Garlic
    lipoprotein(a), a biomarker of atherosclerosis. Because garlic might reduce platelet aggregation, people taking anticoagulant medication are cautioned about...
    59 KB (6,633 words) - 07:01, 21 March 2024
  • Thumbnail for Selectin
    Selectin (category Protein domains)
    E-selectin (in endothelial cells) L-selectin (in leukocytes) P-selectin (in platelets and endothelial cells) L-selectin is the smallest of the vascular selectins...
    19 KB (2,424 words) - 13:08, 20 November 2023
  • group; ** = not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human...
    96 KB (467 words) - 06:58, 14 October 2022
  • patients is refractoriness to platelet transfusions. Thus, the ability to generate platelet products ex vivo and platelet products lacking HLA antigens...
    217 KB (24,998 words) - 23:44, 7 March 2024