Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation...

The Prostacyclin receptor, also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors....

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis...

from the system. Prostacyclin is synthesized from arachidonic acid in endothelial cells. In vascular smooth muscle cells, prostacyclin binds mainly to...

lipoxygenase pathway. The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F. Alternatively, the lipoxygenase enzyme...

Korea, as a vasodilator and antiplatelet agent. It is classified as a prostacyclin analog. It has been studied for the treatment of pulmonary hypertension...

biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family...

conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is expressed in inflammation. PTGS2 (COX-2), converts arachidonic...

reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the resolution phase of inflammation). Prostanoids are seen...

pulmonary arterial hypertension. Treprostinil is a synthetic analog of prostacyclin (PGI2). Treprostinil was approved for use in the United States in May...

formation on damaged sites of small blood vessels and decrease of PgI2 (Prostacyclin) synthesis; it also facilitates platelet aggregation and adhesion, that...

degradation products that inhibit excessive fibrin formation.[citation needed] Prostacyclin (PGI2) is released by endothelium and activates platelet Gs protein-linked...

Specialized pro-resolving mediators § Prostaglandins and isoprostanes). Prostacyclins include: PGI2. Thromboxanes (TX) include the following metabolites of...

thrombomodulin, and prevent platelet aggregation with nitric oxide and prostacyclin. When endothelium of a blood vessel is damaged, the endothelial cells...

ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. It...

aggregation. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The mechanism of secretion of thromboxanes from...

are constricted and blood cannot flow to the tissues. Iloprost is a prostacyclin mimetic. For pulmonary arterial hypertension, iloprost is given via inhalation...

whose selective inhibition results in levels of prostaglandin I2 (PGI2, prostacyclin) down-regulated relative to thromboxane (since COX-1 in platelets is...

effect. There is moderate certainty evidence that intravenous iloprost (prostacyclin analogue) is more effective than aspirin for relieving rest pain and...

Polish pharmacologist and physician. He is known for co-discovering prostacyclin. He was a Member of the Polish Academy of Learning (PAU) and the Polish...

(dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin...

into a different prostaglandin. It is acted upon by: Prostacyclin synthase to create prostacyclin Thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z...

occurring prostanoids viz., prostaglandin D2, (i.e. PGD2), PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the...

(dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin...

Salbutamol Salmeterol Terbutaline Tiotropium Amyl nitrite Iloprost (Prostacyclin) Nitric oxide Beclomethasone Budesonide Ciclesonide Cromolyn Dexamethasone...

prostaglandin H2, which in turn may be converted to various prostaglandins, to prostacyclin, to thromboxanes, and to the 17-carbon product of thromboxane metabolism...

catalyzed cyclooxygenase and lipoxygenase, increases the correlation prostacyclin/ thromboxane A2 and blocks the leukotriene formation. Increases the content...

injection (IP injection), the injection of a substance into the peritoneum Prostacyclin receptor (symbol PTGIR, older synonym IP) IP address, a numerical label...

blood vessels, which leads to a decrease in the production of prostacyclin in them. Prostacyclin usually prevents platelet aggregation and vasoconstriction...

vasoprotective properties. 1-Methylnicotinamide is an endogenous activator of prostacyclin synthesis and can therefore regulate thrombolytic[check spelling] and...