Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that...
105 KB (12,671 words) - 22:43, 25 April 2024
Proteasome inhibitors (INN stem –zomib) are drugs that block the action of proteasomes, cellular complexes that break down proteins. They are being studied...
9 KB (1,094 words) - 16:23, 3 December 2023
Proteasome accessory factor E (abbreviated PafE, also known as bacterial proteasome activator or Bpa) is an ATP-independent proteasome activator of Mycobacterium...
7 KB (760 words) - 13:24, 23 August 2022
PSMB3 (redirect from Proteasome subunit beta type-3)
Proteasome subunit beta type-3, also known as 20S proteasome subunit beta-3, is a protein that in humans is encoded by the PSMB3 gene. This protein is...
23 KB (2,761 words) - 09:31, 18 August 2023
PSMB5 (redirect from Proteasome subunit beta type-5)
Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one...
25 KB (3,119 words) - 14:25, 19 January 2024
PSMB4 (redirect from Proteasome subunit beta type-4)
Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 (based on systematic nomenclature) is a protein that in humans is encoded by...
24 KB (3,031 words) - 08:14, 3 December 2023
PSMB2 (redirect from Proteasome subunit beta type-2)
Proteasome subunit beta type-2 also known as 20S proteasome subunit beta-4 (based on systematic nomenclature) is a protein that in humans is encoded by...
23 KB (2,861 words) - 14:37, 3 December 2023
prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn...
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affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or...
98 KB (11,068 words) - 02:47, 20 February 2024
In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction ATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP +...
2 KB (143 words) - 13:26, 27 August 2023
PSMB1 (redirect from Proteasome subunit beta type-1)
Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by...
25 KB (3,183 words) - 04:46, 19 October 2022
POMP (redirect from Proteasome maturation protein)
Proteasome maturation protein is a protein that in humans is encoded by the POMP gene. It is a short-lived maturation factor required for 20S proteasome...
5 KB (576 words) - 01:32, 4 March 2023
Proteolysis (section Lysosome and proteasome)
lysosome, or a ubiquitin-dependent process that targets unwanted proteins to proteasome. The autophagy-lysosomal pathway is normally a non-selective process,...
34 KB (4,225 words) - 03:34, 2 April 2024
peptides generated mainly from degradation of cytosolic proteins by the proteasome. The MHC I:peptide complex is then inserted via endoplasmic reticulum...
21 KB (2,606 words) - 12:21, 5 April 2024
Bortezomib (category Proteasome inhibitors)
syndrome. It is in the class of medications known as proteasome inhibitor. It works by inhibiting proteasomes, cellular complexes that break down proteins. Bortezomib...
24 KB (2,176 words) - 20:17, 26 January 2024
an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent. carfilzomib: a proteasome inhibitor that is indicated: as a single...
127 KB (13,052 words) - 10:10, 8 May 2024
Proteasome subunit alpha type-5 also known as 20S proteasome subunit alpha-5 is a protein that in humans is encoded by the PSMA5 gene. This protein is...
25 KB (2,993 words) - 14:07, 25 August 2023
Recent evidences on proteasome complex structure confirmed that the protein encoded by gene ADRM1, also known in yeast as 26S Proteasome regulatory subunit...
14 KB (1,819 words) - 19:38, 14 October 2022
26S proteasome non-ATPase regulatory subunit 14, also known as 26S proteasome non-ATPase subunit Rpn11, is an enzyme that in humans is encoded by the...
22 KB (2,795 words) - 10:10, 10 January 2024
Endoplasmic-reticulum-associated protein degradation (section Ubiquitin-dependent degradation by the proteasome)
and subsequent degradation by a protein-degrading complex, called the proteasome. The process of ERAD can be divided into three steps: The recognition...
13 KB (1,707 words) - 01:53, 3 December 2023
Proteasome subunit alpha 8 also known as proteasome subunit alpha type-7-like is a protein that in humans is encoded by the PSMA8 gene. Proteasome subunit...
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the proteasome on the basis of its affinity for certain catalytic subunits of the proteasome by Fenteany and co-workers in 1995. The proteasome is a...
5 KB (332 words) - 19:39, 26 March 2024
26S protease regulatory subunit 4, also known as 26S proteasome AAA-ATPase subunit Rpt2, is an enzyme that in humans is encoded by the PSMC1 gene. This...
31 KB (3,857 words) - 03:19, 21 October 2022
Proteasome subunit alpha type-1 is a protein that in humans is encoded by the PSMA1 gene. This protein is one of the 17 essential subunits (alpha subunits...
24 KB (2,972 words) - 09:47, 18 August 2023
signal peptide for protein degradation. This may be mediated via the proteasome or calpain. Rogers S, Wells R, Rechsteiner M (1986). "Amino acid sequences...
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Proteasome subunit alpha type-6 is a protein that in humans is encoded by the PSMA6 gene. This protein is one of the 17 essential subunits (alpha subunits...
25 KB (3,040 words) - 03:19, 3 December 2023
Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene. This protein is one...
32 KB (3,957 words) - 10:58, 23 December 2023
KIAA0368 (redirect from Proteasome-associated protein ECM29 homolog)
Proteasome-associated protein ECM29 homolog is a protein that in humans is encoded by the KIAA0368 gene. GRCh38: Ensembl release 89: ENSG00000136813 –...
4 KB (545 words) - 18:59, 13 October 2022
An immunoproteasome is a type of proteasome that degrades ubiquitin-labeled proteins found in the cytoplasm in cells exposed to oxidative stress and proinflammatory...
6 KB (798 words) - 12:41, 15 June 2022
Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene...
26 KB (3,160 words) - 18:33, 10 April 2024