• Recombinant factor VIIa (rfVIIa) is a form of blood factor VII that has been manufactured via recombinant technology. It is administered via an injection...
    19 KB (1,756 words) - 15:27, 27 January 2024
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    factor VII), which in turn activates factor IX and factor X. Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include...
    12 KB (1,376 words) - 17:01, 10 May 2024
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    peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form, where...
    31 KB (1,943 words) - 17:09, 10 May 2024
  • plasma (FFP), vitamin K, prothrombin complex concentrates, or recombinant factor VIIa can be given to reverse the effect of warfarin. High doses of vitamin...
    54 KB (5,859 words) - 15:59, 13 May 2024
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    trauma. For severe bleeding, for example from bleeding disorders, recombinant factor VIIa—a protein that assists blood clotting—may be appropriate. While...
    59 KB (6,703 words) - 03:31, 12 April 2024
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    recombinant factor VIIa, and prothrombin complex concentrate (PCC) have been utilized with proven efficacy. Specifically with warfarin, four-factor PCC...
    78 KB (8,726 words) - 15:18, 29 April 2024
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    kind of pregnancy, with others even using tranexamic acid and recombinant factor VIIa, which both minimize blood loss. Generally, unless the placenta...
    26 KB (2,859 words) - 04:25, 5 May 2024
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    (only if bleeding is severe; risk of platelet alloimmunization) Recombinant factor VIIa, AryoSeven or NovoSeven FDA approved this drug for the treatment...
    10 KB (1,027 words) - 15:47, 4 May 2024
  • trials to understand more about the potential benefits and risks. Recombinant factor VIIa (rFVIIa) is not, as of 2012, supported by the evidence for most...
    20 KB (2,391 words) - 17:27, 30 March 2024
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    factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor Xa. Together with factor VIIa, tissue factor forms...
    15 KB (1,833 words) - 16:50, 10 May 2024
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    time (INR) every one to four weeks. Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness...
    94 KB (9,772 words) - 05:31, 19 April 2024
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    of whether there is poor nutritional status. Administration of recombinant factor VIIa has shown promise; however, this treatment approach requires further...
    37 KB (4,266 words) - 16:05, 10 January 2024
  • Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity. J Thromb Haemost 2004; 2:1700-1708...
    10 KB (1,468 words) - 18:35, 1 October 2022
  • hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa. J Thromb Haemost. 2004;2:102-10. Karger R, Egbring R, Weippert-Kretschmer...
    19 KB (2,428 words) - 14:04, 5 December 2022
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    fresh frozen plasma are commonly used coagulation factor products. Recombinant activated human factor VII is increasingly popular in the treatment of major...
    61 KB (5,960 words) - 10:29, 11 May 2024
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    activated factor VIIa (normally present in trace amounts in the blood), forming the extrinsic tenase complex. This complex further activates factor IX and...
    23 KB (2,402 words) - 15:31, 15 January 2024
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    1980s. Lusher later conducted the first studies on the use of recombinant factor VIIa in the treatment of bleeding episodes in patients with hemophilia...
    14 KB (1,906 words) - 06:26, 4 June 2023
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    between intensive and less intensive blood pressure control. Giving Factor VIIa within 4 hours limits the bleeding and formation of a hematoma. However...
    44 KB (4,483 words) - 13:03, 4 May 2024
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    promptly to prevent further complications. In the case of DIC, recombinant activated factor VIIa is quick way to address this issue. Serine proteinase inhibitor...
    18 KB (1,947 words) - 11:31, 26 March 2024
  • investigator of a multinational multicenter testing program evaluating recombinant factor VIIa for this indication. Mayer predominantly uses invasive brain multimodality...
    17 KB (1,770 words) - 02:46, 22 November 2023
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    Factor II (thrombin) (IIa), and also the activated form of Factor VII (VIIa) from the tissue factor pathway (formerly known as the extrinsic pathway). The...
    45 KB (5,331 words) - 23:48, 9 March 2024
  • 2008, the company sold its MAXY-VII candidate drug, a recombinant form of clotting factor VIIa, to Bayer HealthCare. 2009 saw the formation of a joint...
    9 KB (880 words) - 02:18, 3 February 2023
  • slow, tight-binding inhibitor of factor Xa with a Ki value of 0.3–0.6 nM but it also inhibits trypsin. Recombinant Antistasin can be produced by genetically...
    41 KB (4,917 words) - 22:24, 10 May 2024
  • development and commercialization of three drug candidates, recombinant blood clotting factors VIIa, VIII and IX, the latter of which is in clinical trials...
    10 KB (885 words) - 10:13, 28 February 2024
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    of transfusions may be reduced if these patients are given recombinant human factor VIIa[medical citation needed] since the underlying cause are antibodies...
    24 KB (3,124 words) - 05:53, 21 October 2023
  • factor va MeSH D23.119.325.300 – factor viia MeSH D23.119.350.300 – factor viiia MeSH D23.119.375.310 – factor ixa MeSH D23.119.400.315 – factor xa...
    86 KB (8,039 words) - 16:46, 9 February 2024