is encoded by the SARM1 gene. It is the most evolutionarily conserved member of the Toll/Interleukin receptor-1 (TIR) family. SARM1's TIR domain has intrinsic...
49 KB (5,231 words) - 18:39, 5 May 2024
Wallerian degeneration (section SARM1)
linked to SARM1 activation. MAPK signaling has been shown to promote the loss of NMNAT2, thereby promoting SARM1 activation, although SARM1 activation...
41 KB (5,080 words) - 23:57, 25 November 2023
Certain enzymes are sensitive to the intracellular NMN/NAD+ ratio, such as SARM1, a protein responsible for initiating cellular degeneration pathways such...
19 KB (1,797 words) - 02:50, 5 April 2024
(TIR) homology domain is an intracellular signaling domain found in MyD88, SARM1, interleukin-1 receptors, toll receptors and many plant R proteins. It contains...
8 KB (839 words) - 21:44, 4 April 2024
Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1. Vogel, R. P. (1982). "Poisoning with Vacor Rodenticide". Archives of Pathology...
3 KB (174 words) - 22:05, 3 February 2024
NAD+ glycohydrolase (section SARM1)
regulating adaptive immunity as T cells contain enzymes such as CD38 and SARM1 that consumes NAD+. CD38 is an enzyme that triggers inflammatory responses...
8 KB (867 words) - 18:53, 5 May 2024
Examples of proteins that contain armadillo repeats include β-catenin, Sarm1 (SARM1), α-importin, plakoglobin, adenomatous polyposis coli (APC), and many...
5 KB (571 words) - 20:27, 2 December 2023
a much weaker catalyst than CD38. The SARM1 enzyme also catalyzes the formation of cADPR from NAD+, but SARM1 elevates cADPR much more efficiently than...
35 KB (3,825 words) - 18:37, 5 May 2024
enhancement opposes the actions of SARM1 which would lead to axon degeneration, but this effect is not due to preventing SARM1 depletion of NAD+. Mice lacking...
7 KB (828 words) - 00:07, 3 December 2023
Therapeutics and its experimental treatments for axonal degeneration, via SARM1 inhibitors, for $135 million (plus a further $1.225 billion based on regulatory...
164 KB (15,128 words) - 23:57, 28 April 2024
Selective androgen receptor modulator (SARM), a class of experimental drugs SARM1, an enzyme Saskatchewan Association of Rural Municipalities Service d'action...
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Q9Y6B6 14283 SARAF HGNC:28789 Q96BY9 14284 SARDH HGNC:10536 Q9UL12 14285 SARM1 HGNC:17074 Q6SZW1 14286 SARNP HGNC:24432 P82979 14287 SARS1 HGNC:10537 P49591...
282 KB (17 words) - 23:17, 27 April 2024
enhancement opposes the actions of SARM1 which would lead to axon degeneration, but this effect is not due to preventing SARM1 depletion of NAD+. Mutations...
12 KB (1,469 words) - 00:07, 3 December 2023
activity to cleave the metabolite NAD+, as first discovered in the protein SARM1. The ability of TIR domains to consume NAD+ is a primordial function of...
13 KB (1,572 words) - 21:44, 19 February 2023
(2015-06-10). "Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons". Nature Communications. 6: ncomms8319...
19 KB (2,288 words) - 06:53, 20 May 2024
of cADPR, i.e. the one between the two phosphate groups, was reported. SARM1 and other TIR domain-containing proteins also catalyze the formation of...
12 KB (1,183 words) - 14:06, 24 November 2023
SAMD1; SAMD13; SAMD14; SAMD3; SAMD4A; SAMD4B; SAMD5; SAMD7; SAMD8; SAMD9; SARM1; SCMH1; SCML1; SCML2; SEC23IP; SGMS1; SHANK1; SHANK2; SHANK3; STARD13; UBP1;...
8 KB (835 words) - 11:45, 22 March 2024
Dabas, Hadas; Hammarlund, Marc (2022-03-14). "Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by...
15 KB (1,790 words) - 23:36, 3 February 2024
may be other routes which require different substrates and enzymes. The SARM1 enzyme also catalyzes the formation of NAADP from NAD+. The first chemical...
53 KB (6,140 words) - 19:05, 16 April 2024