Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. The most common type... 139 KB (14,989 words) - 15:34, 5 April 2024 |
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established... 8 KB (996 words) - 20:51, 19 January 2024 |
their organs. In November 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus Pauling, Harvey Itano and... 5 KB (579 words) - 00:39, 22 October 2023 |
concept was introduced in 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus Pauling, Harvey Itano and... 13 KB (1,439 words) - 22:31, 21 February 2024 |
Hemoglobin C (redirect from Hemoglobin c disease) C disease and can experience mild anemia. It is possible for a person to have both the gene for hemoglobin S (the form associated with sickle cell anemia)... 20 KB (2,359 words) - 02:40, 20 February 2023 |
Linus Pauling (category Members of the International Academy of Quantum Molecular Science) discovery of sickle cell anemia as a "molecular disease" opened the way toward examining genetically acquired mutations at a molecular level. Pauling's... 141 KB (13,950 words) - 01:50, 17 April 2024 |
Hemoglobin D (category Genetic diseases and disorders) PMC 4241286. PMID 25431740. Pauling L, Itano HA (November 1949). "Sickle cell anemia a molecular disease". Science. 110 (2865): 543–8. Bibcode:1949Sci...110..543P... 33 KB (3,748 words) - 21:23, 7 March 2024 |
and Pauling's concept of "molecular disease" (first articulated in his 1949 study, "Sickle Cell Anemia, a Molecular Disease"). Pauling argues that the... 6 KB (805 words) - 04:57, 10 January 2022 |
Harvey Itano (redirect from Harvey A. Itano) American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases. In collaboration with Linus Pauling, Itano used... 10 KB (839 words) - 14:59, 5 March 2024 |
Beta thalassemia (redirect from Beta-thalassemia major anemia) well as sickle cell anemia by inhibiting the BCL11A gene are also being explored. Patients with thalassemia major are more inclined to have a splenectomy... 46 KB (4,484 words) - 12:51, 13 April 2024 |
Pleiotropy (section Sickle cell anemia) phenylalanine to build up in the body. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of... 40 KB (4,786 words) - 06:59, 11 March 2024 |
Complete blood count (redirect from Blood cell count) diagnose a hemoglobinopathy such as thalassemia or sickle cell disease. The white blood cell and platelet counts are markedly increased, and anemia is present... 105 KB (12,442 words) - 12:58, 3 November 2023 |
colleagues show in "Sickle Cell Anemia, a Molecular Disease" that a human genetic disease, sickle cell anemia, is caused by a molecular change in a specific protein... 20 KB (2,419 words) - 23:57, 27 November 2023 |
Protein biosynthesis (section Sickle cell disease) transporting oxygen. The most dangerous of the sickle cell diseases is known as sickle cell anemia. Sickle cell anemia is the most common homozygous recessive... 40 KB (4,342 words) - 18:58, 2 April 2024 |
Heterozygote advantage (section Sickle-cell anemia) experience the ill effects of the disease, yet will still possess a sickle cell trait, whereby some of the red blood cells undergo benign effects of SCA,... 24 KB (3,014 words) - 12:07, 9 June 2023 |
Human genetic resistance to malaria (category Cell biology) PMID 13433567. Pauling L, Itano H, Singer SJ, Wells I (1949). "Sickle cell anemia, a molecular disease" (PDF). Science. 110 (2865): 543–548. Bibcode:1949Sci.... 75 KB (9,634 words) - 15:14, 28 February 2024 |
Hemolysis (redirect from Red blood cell breakdown) hemolytic anemia, atypical hemolytic uremic syndrome (aHUS)), some genetic disorders (e.g., Sickle-cell disease or G6PD deficiency), or blood with too low a solute... 29 KB (2,687 words) - 01:43, 14 January 2024 |
Gene therapy (redirect from List of gene therapies for treatment of genetic disease) focused on diseases caused by single-gene defects, such as cystic fibrosis, haemophilia, muscular dystrophy, thalassemia, and sickle cell anemia. Glybera... 172 KB (17,769 words) - 04:04, 1 April 2024 |
Bibliography of biology (section Molecular biology) as a source of inspiration for his initial research. Pauling, Linus; Harvey A. Itano; S. J. Singer; Ibert C. Wells (1949). "Sickle Cell Anemia, a Molecular... 34 KB (3,535 words) - 21:48, 24 March 2024 |
Seymour Jonathan Singer (category American cell biologists) basis of abnormal hemoglobin in sickle-cell anemia, reported in the famous paper "Sickle Cell Anemia, a Molecular Disease". He worked for the U.S. Public... 6 KB (524 words) - 09:36, 7 April 2024 |
Hemoglobin (section Presence in nonerythroid cells) in a population, caused by variations in genetics. Some well-known hemoglobin variants, such as sickle-cell anemia, are responsible for diseases and... 99 KB (11,567 words) - 17:51, 20 March 2024 |
Genetic studies on Arabs (redirect from Genetic diseases of the Arab world) alpha-thalassemia, molecular characterization, recessive osteoperosis, gluthanione-reducatsafe DEf. A study about sickle cell anemia in Arabs article about... 66 KB (6,347 words) - 22:39, 13 April 2024 |