Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily...

Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the...

Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels. The following naturally-produced substances...

epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions...

of the sodium channels and are equally large. Cation channels of sperm: This small family of channels, normally referred to as Catsper channels, is related...

A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels. Examples include toxins, such as aconitine, veratridine...

this is known as depolarization and is mainly due to the opening of sodium channels that allow Na+ to flow into the cell. After a delay (known as the absolute...

plasma membrane to reverse, and the ion channels then rapidly inactivate. As the sodium channels close, sodium ions can no longer enter the neuron, and...

voltage-gated ion channels directionally propagate electrical signals. Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na+)...

The most commonly involved gene is SCN5A which encodes the cardiac sodium channel. Diagnosis is typically by electrocardiogram (ECG), however, the abnormalities...

as either channels or carriers. Examples of channel/carrier proteins include the GLUT 1 uniporter, sodium channels, and potassium channels. The solute...

type of voltage-gated sodium channel that underlies action potentials—these are sometimes called Hodgkin-Huxley sodium channels because they were initially...

excitatory neurotransmitters via voltage-sensitive sodium channels and voltage-gated calcium channels in neurons. Lamotrigine was first marketed in Ireland...

group 1B), voltage-gated sodium channel modulators (3A), nicotinic acetylcholine receptor modulators (5), chloride channel activators (6), midgut membrane...

opening of voltage-gated sodium channels, this results in an influx of sodium ions down their electrochemical gradient. Sodium ions enter the cell, and...

Martinez-Lavin M (February 2012). "A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia". BMC Musculoskeletal...

An epithelial sodium channel blocker is a sodium channel blocker that is selective for the epithelial sodium channel. An example is amiloride, which is...

heart to stop suddenly, known as respiratory arrest and cardiac arrest. Sodium channel blockers, like benzocaine, lidocaine, phenytoin, and tricaine methanesulfonate...

potassium channel activity, thereby allowing the study of neuron response contributions of other ion channels such as voltage gated sodium channels. In addition...

corresponds to the influx of sodium ions, whereas the two decays ("1" and "3", respectively) correspond to the sodium-channel inactivation and the repolarizing...

alpha-subunit of the voltage gated sodium channel (SCN4A). Like chloride channel mutations, patients with sodium channel mutations may have a very varied...

A variety of alpha subunit voltage-gated sodium channels have been identified. Voltage-gated sodium channels found in mammals can be divided into three...

selective Nav1.7 blocker Cenobamate (YKP-3089) – atypical voltage-gated sodium channel blocker.: 5593–5605  DSP-2230 – selective Nav1.7 and Nav1.8 blocker...

of the transmembrane sodium channel protein. A mutation this gene will cause an individual to develop dysfunctional sodium channel Nav 1.1, which is crucial...

Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder...

Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca2+...

from the four channel subunits [1]. It may seem counterintuitive that a channel should allow potassium ions but not the smaller sodium ions through. However...

grayanotoxin only binds to the activated conformation of sodium channels. Normally, voltage gated sodium channels are activated (opened) only when the cell membrane...

breastfeeding is safe. Benzonatate is a local anesthetic and voltage-gated sodium channel blocker.[unreliable medical source?] It is theorized to work by inhibiting...

Sodium channel protein type 5 subunit alpha, also known as NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel...