A telomere (/ˈtɛləmɪər, ˈtiːlə-/; from Ancient Greek τέλος (télos) 'end', and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated...

Telomeres, the caps on the ends of eukaryotic chromosomes, play critical roles in cellular aging and cancer. An important facet to how telomeres function...

The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan...

A mega-telomere (also known as an ultra-long telomere or a class III telomere), is an extremely long telomere sequence that sits on the end of chromosomes...

Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers...

ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each...

cell undergoes mitosis, the telomeres on the ends of each chromosome shorten slightly. Cell division will cease once telomeres shorten to a critical length...

Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres. At each end...

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere (insect morphology), a type...

Telomere resolvase, also known as protelomerase, is an enzyme found in bacteria which contain linear plasmids. In order to prevent exonuclease degradation...

California, Berkeley. Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for...

of telomeres is now clearly evident: lengthen the telomeres, lengthen the life. However, a study of the comparative biology of mammalian telomeres indicated...

senescence can be triggered by a DNA damage response due to the shortening of telomeres. Cells can also be induced to senesce by DNA damage in response to elevated...

1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For this work, she was awarded the 2009 Nobel Prize...

in a long circle stabilized by telomere-binding proteins. At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded...

playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable...

Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate...

below: Primary hallmarks (causes of damage) Genome instability Telomere shortening (or telomere attrition) Epigenetic alterations Loss of proteostasis Antagonistic...

Gene therapy Microbial biodegradation Omics Pharmacogenomics Stem cells Telomere Tissue culture Interdisciplinary fields Bioeconomy Bioelectronics Bioengineering...

A telomere (pl.; telomeres or telomeron), literally "end piece", is a term in insect morphology, and refers to a type of "genital clasper"; i.e.: in Mallophaga...

because it leads to chromosome end loss or true telomere loss. Clastogens can bring on issues with telomeres and cause them to fail to function as intended...

exhibit accelerated telomere shortening, indicating that there may be a connection between the loss of the WRN helicase activity and telomere and cell instability...

Ala-Glu-Asp-Gly and the molecular formula C14H22N4O9. Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in...

repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that...

person has was found to have a correlation with telomere length. However, the relation between telomeres and aging remains uncertain. The American Academy...

which both copies of each chromosome are identical led to the first telomere-to-telomere, truly complete sequence of a human chromosome, the X chromosome...

species longevity with DNA double strand break recognition but not with telomere length". Mechanisms of Ageing and Development. 130 (11–12): 784–792. doi:10...

end-to-end fully. Once the telomeres have reached a critical length the cell can no longer divide and can hence cause telomere-dependent replicative senescence...

presence of vestigial telomeres. These are normally found only at the ends of a chromosome, but in chromosome 2 there are additional telomere sequences in the...

Giemsa staining). They are counted from the centromere out toward the telomeres. A range of loci is specified in a similar way. For example, the locus...