Thalassemias are inherited blood disorders that result in abnormal hemoglobin. Symptoms depend on the type of thalassemia and can vary from none to severe...
59 KB (6,571 words) - 14:16, 11 May 2024
Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the...
54 KB (4,880 words) - 18:03, 28 April 2024
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood...
21 KB (1,581 words) - 17:11, 28 April 2024
Hemoglobin A2 (section Thalassemia)
Hemoglobin A2 may be increased in beta thalassemia or in people who are heterozygous for the beta thalassemia gene. HbA2 exists in small amounts in all...
9 KB (1,204 words) - 06:46, 29 February 2024
Hemoglobin A (section Alpha-thalassemia)
to have a “silent” α-thalassemia whereas, if the mutation is on both then it is considered an α-thalassemia trait. α-thalassemia is mostly found in sub-tropical...
17 KB (2,054 words) - 07:59, 27 February 2024
Delta-beta thalassemia is a rare form of thalassemia in which there is a reduced production of hemoglobin subunit delta and hemoglobin subunit beta and...
8 KB (655 words) - 13:46, 21 March 2024
said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. The index is calculated from the results of a complete blood count...
3 KB (293 words) - 15:06, 28 June 2023
Treatment of the inherited blood disorder thalassemia depends upon the level of severity. For mild forms of the condition, advice and counseling are often...
34 KB (4,028 words) - 16:22, 24 February 2024
Microcytic anemia (section Thalassemia)
general and of microcytic anemia in particular Thalassemia Adulthood Iron deficiency anemia Thalassemia Anemia of chronic disease Rare hereditary causes...
16 KB (1,705 words) - 22:21, 26 September 2023
variants are HbS, HbE and HbC. The main types of thalassemia are alpha-thalassemia and beta thalassemia. The two conditions may overlap because some conditions...
19 KB (2,206 words) - 18:01, 24 April 2024
ATR-X syndrome (redirect from X-linked alpha thalassemia mental retardation syndrome)
Alpha-thalassemia mental retardation syndrome (ATRX), also called alpha-thalassemia X-linked intellectual disability syndrome, nondeletion type or ATR-X...
10 KB (1,149 words) - 11:06, 22 April 2024
amounts of anomalous β mRNA. The reduced synthesis of β chain may cause β-thalassemia. Also, this hemoglobin variant has a weak union between α- and β-globin...
11 KB (1,184 words) - 00:14, 24 January 2024
heterozygous (inherited in only one of the chromosome 11) HbD trait, HbD-thalassemia, HbS-D (sickle cell) disease, and, very rarely, homozygous (inherited...
33 KB (3,748 words) - 21:23, 7 March 2024
Hemoglobin subunit beta (section Beta thalassemia)
implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria....
18 KB (2,398 words) - 03:47, 2 May 2024
the treatment of sickle cell disease and transfusion-dependent beta thalassemia. It was developed by Vertex Pharmaceuticals and CRISPR Therapeutics....
20 KB (1,433 words) - 07:08, 3 March 2024
alpha-thalassemia intermedia, is a disease affecting hemoglobin, the oxygen carrying molecule within red blood cells. It is a form of Alpha-thalassemia which...
9 KB (936 words) - 14:34, 26 April 2024
chain that is abnormally long. It is the most common nondeletional alpha-thalassemia mutation associated with hemoglobin H disease. The quantity of hemoglobin...
2 KB (146 words) - 02:51, 29 September 2019
attributed to various anemias, most often; beta thalassemia major, a form of microcytic anemia. In β thalassemia major the beta hemoglobin chain is completely...
2 KB (132 words) - 19:19, 1 December 2023
hemoglobin, such as hemoglobin C. It can also be used to investigate thalassemias, which are disorders caused by defective hemoglobin production. The test...
5 KB (540 words) - 12:49, 23 April 2022
name Reblozyl, is a medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes. The US Food and Drug Administration (FDA)...
11 KB (802 words) - 06:07, 17 April 2024
Transfusion-dependent anemia (section Thalassemia)
and transfusion-dependent thalassemia is diagnosed based on gene mutations. Screening for heterozygosity in the thalassemia gene is an option for early...
25 KB (2,866 words) - 07:17, 4 January 2024
include iron deficiency, folate deficiency, vitamin B12 deficiency, thalassemia and a number of bone marrow tumors. Causes of increased breakdown include...
86 KB (8,800 words) - 04:26, 6 May 2024
Fetal hemoglobin (section Delta beta-thalassemia)
adult forms of hemoglobin begin to be produced. Diseases such as beta thalassemias, which affect components of the adult hemoglobin, can delay this process...
38 KB (4,539 words) - 06:32, 20 April 2024
commercialize medicines for various diseases including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes, and cardiovascular diseases. The CEO...
11 KB (918 words) - 14:13, 19 April 2024
membranes or may be increased red cell membrane fluidity. Alpha-thalassemia and beta-thalassemia Hemoglobin C Disease Iron deficiency anemia Post-splenectomy:...
6 KB (706 words) - 16:12, 15 January 2024
ancestry. Hereditary blood disorders, such as sickle cell anemia and thalassemia, produce an effect on the development of hemoglobin, which, consequently...
144 KB (15,327 words) - 18:36, 7 May 2024
HB electrophoresis, which aimed to decrease the incidence of SCD and thalassemia. In Bahrain, a study published in 1998 that covered about 56,000 people...
142 KB (15,226 words) - 20:50, 12 May 2024
iron deficiency anemia and decreased or normal in thalassemia major (Cooley's anemia), thalassemia intermedia Anisocytosis with normal RBC size – Early...
3 KB (264 words) - 04:15, 19 November 2022
globins bind to form hemoglobin Barts. It is produced in the disease alpha-thalassemia and in the most severe of cases, it is the only form of hemoglobin in...
9 KB (1,049 words) - 04:38, 28 April 2024
Sickle cell trait (section Alpha-thalassemia)
percent of red blood cells present in the blood) are measured. Alpha-thalassemia, like sickle cell trait, is typically inherited in areas with increased...
26 KB (2,892 words) - 10:57, 15 April 2024