The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan... 18 KB (1,998 words) - 04:49, 1 April 2024 |
Telomerase (category Telomere-related proteins) ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each... 49 KB (5,644 words) - 06:05, 27 April 2024 |
Telomeres, the caps on the ends of eukaryotic chromosomes, play critical roles in cellular aging and cancer. An important facet to how telomeres function... 22 KB (2,640 words) - 02:45, 1 December 2023 |
Hayflick limit (section Telomere length) cell undergoes mitosis, the telomeres on the ends of each chromosome shorten slightly. Cell division will cease once telomeres shorten to a critical length... 16 KB (1,876 words) - 19:40, 20 April 2024 |
A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere (insect morphology), a type... 325 bytes (71 words) - 09:06, 11 January 2019 |
Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers... 13 KB (1,658 words) - 08:34, 4 December 2022 |
Eternal youth (section Telomeres) of telomeres is now clearly evident: lengthen the telomeres, lengthen the life. However, a study of the comparative biology of mammalian telomeres indicated... 9 KB (1,089 words) - 08:04, 29 February 2024 |
Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres. At each end... 6 KB (728 words) - 06:34, 5 March 2023 |
California, Berkeley. Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for... 31 KB (2,861 words) - 09:44, 17 April 2024 |
A telomere (pl.; telomeres or telomeron), literally "end piece", is a term in insect morphology, and refers to a type of "genital clasper"; i.e.: in Mallophaga... 888 bytes (83 words) - 03:10, 19 July 2021 |
Telomerase reverse transcriptase (category Telomere-binding proteins) distinct subgroup of RNA-dependent polymerases. Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise... 46 KB (5,301 words) - 23:59, 12 April 2024 |
DNA end resection (section Resection of telomere DSBs) complex specialized DNA protective packages called telomeres that prevent DNA repair activities. Telomeres and mitotic DSBs have different functionality,... 18 KB (2,277 words) - 13:23, 26 November 2023 |
Cellular senescence (section Role of telomeres) senescence can be triggered by a DNA damage response due to the shortening of telomeres. Cells can also be induced to senesce by DNA damage in response to elevated... 57 KB (6,395 words) - 02:55, 28 March 2024 |
Telomere resolvase, also known as protelomerase, is an enzyme found in bacteria which contain linear plasmids. In order to prevent exonuclease degradation... 1 KB (112 words) - 06:22, 29 November 2023 |
His research has focused on the biology of blood-forming stem cells, telomeres and genome analysis. He is also known for developing techniques including... 16 KB (1,663 words) - 05:19, 29 April 2024 |
Hallmarks of aging (section Telomere shortening) below: Primary hallmarks (causes of damage) Genome instability Telomere shortening (or telomere attrition) Epigenetic alterations Loss of proteostasis Antagonistic... 40 KB (4,312 words) - 19:06, 19 April 2024 |
Telomeric repeat–containing RNA (category Telomere-related genes) repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that... 35 KB (4,668 words) - 11:25, 11 February 2024 |
which both copies of each chromosome are identical led to the first telomere-to-telomere, truly complete sequence of a human chromosome, the X chromosome... 64 KB (7,206 words) - 17:46, 14 April 2024 |
LINE1 (section Assistance to telomere reprogramming) Nr2e3 gene. It has been suggested that L1s may directly contribute to telomere reprogramming at the 2-cell stage of embryo development. In 2021, a study... 26 KB (2,823 words) - 06:01, 15 January 2024 |
Paternal age effect (section Telomere length) greater age at paternity tends to increase telomere length in offspring for up to two generations. Since telomere length has effects on health and mortality... 52 KB (5,416 words) - 07:15, 22 April 2024 |
Shelterin (category Telomere-binding proteins) Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate... 21 KB (2,334 words) - 22:51, 9 April 2024 |