• Thumbnail for Thrombin
    Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation...
    26 KB (2,946 words) - 11:32, 24 March 2024
  • Thumbnail for Thrombin time
    The thrombin time (TT), also known as the thrombin clotting time (TCT), is a blood test that measures the time it takes for a clot to form in the plasma...
    5 KB (599 words) - 19:37, 22 April 2022
  • Thumbnail for Thrombin receptor
    There are three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are...
    5 KB (591 words) - 02:36, 29 November 2023
  • A thrombin generation assay (TGA) or thrombin generation test (TGT) is a global coagulation assay (GCA) and type of coagulation test which can be used...
    6 KB (614 words) - 06:17, 13 August 2023
  • Thumbnail for Fibrin
    involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together...
    7 KB (722 words) - 21:39, 21 April 2024
  • thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor...
    7 KB (821 words) - 09:44, 30 January 2023
  • Thumbnail for Coagulation
    factor X, thrombin and fibrin. The main role of the tissue factor (TF) pathway is to generate a "thrombin burst", a process by which thrombin, the most...
    61 KB (5,960 words) - 07:37, 28 April 2024
  • Thrombin inhibitor may refer to: Direct thrombin inhibitor Indirect thrombin inhibitor, such as warfarin This disambiguation page lists articles associated...
    133 bytes (46 words) - 16:05, 30 December 2019
  • Thumbnail for Prothrombin time
    thromboplastin time (PTT), or activated partial thromboplastin time (aPTT or APTT) Thrombin time (TT) Thrombodynamics test Thromboelastography Thrombus Health Mo....
    24 KB (3,091 words) - 20:46, 8 March 2024
  • Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in...
    6 KB (648 words) - 03:34, 13 August 2023
  • Thumbnail for Fibrin glue
    wound healing. It contains separately packaged human fibrinogen and human thrombin. This glue is used as a supportive treatment in surgery (such as liver...
    15 KB (1,239 words) - 20:43, 10 April 2024
  • Thumbnail for Anti-thrombin aptamers
    Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA...
    23 KB (2,656 words) - 15:18, 15 August 2023
  • to a thrombin generation assay (TGA). This results in an inhibition of thrombin generation as measured by reduction of the endogenous thrombin potential...
    15 KB (1,523 words) - 11:50, 24 January 2024
  • Thumbnail for Pseudoaneurysm
    minimally-invasive technique used today is ultrasound-guided thrombin injection. Thrombin (factor IIa in the coagulation cascade) is a clotting factor...
    11 KB (1,353 words) - 06:36, 19 November 2023
  • Thumbnail for Partial thromboplastin time
    "Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism". American Journal...
    9 KB (954 words) - 04:40, 9 April 2024
  • Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase...
    215 bytes (60 words) - 16:05, 30 December 2019
  • Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various...
    33 KB (3,756 words) - 17:07, 14 December 2023
  • Thumbnail for Dabigatran
    Dabigatran (category Direct thrombin inhibitors)
    thrombin molecule, preventing thrombin-mediated activation of coagulation factors. Furthermore, dabigatran can inactivate thrombin even when thrombin...
    37 KB (3,249 words) - 23:05, 26 January 2024
  • Thumbnail for Anticoagulant
    non-vitamin K antagonist oral anticoagulants. These agents include direct thrombin inhibitor (dabigatran) and factor Xa inhibitor (rivaroxaban, apixaban,...
    78 KB (8,783 words) - 21:47, 19 April 2024
  • Thumbnail for Heparin
    interaction with thrombin. The formation of a ternary complex between AT, thrombin, and heparin results in the inactivation of thrombin. For this reason...
    77 KB (7,861 words) - 06:21, 9 April 2024
  • (factor II), an inactive zymogen, to thrombin (factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation...
    25 KB (3,112 words) - 19:03, 28 February 2024
  • Thumbnail for Protease
    may contain many hundreds of related proteases (e.g. trypsin, elastase, thrombin and streptogrisin within the S1 family). Currently more than 50 clans are...
    26 KB (2,799 words) - 22:42, 25 April 2024
  • Thumbnail for Anti-thrombin antibodies
    Anti-thrombin antibodies are autoantibodies directed against thrombin that may constitute a fraction of lupus anticoagulant and are seen an increased levels...
    4 KB (381 words) - 00:09, 12 December 2020
  • response in the clotting system, which in turns stimulates thrombin production. Thrombin also causes platelet aggregation. As such, more often than not...
    9 KB (1,278 words) - 22:10, 30 October 2023
  • Thumbnail for Thrombomodulin
    endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant...
    13 KB (1,470 words) - 08:24, 26 March 2024
  • Thumbnail for Antithrombin
    refers to the binding of thrombin to fibrin, after thrombin has activated fibrinogen, at a non-catalytic binding site of thrombin. Antithrombin II (AT II)...
    45 KB (5,331 words) - 23:48, 9 March 2024
  • Thumbnail for Factor X
    pathway or thrombin pathway. It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process...
    27 KB (3,302 words) - 09:03, 10 March 2024
  • generation of thrombin, an enzyme that turns the soluble blood protein fibrinogen into fibrin, which aggregates into protofibrils. Another thrombin-generated...
    20 KB (2,197 words) - 21:25, 25 February 2024
  • Thumbnail for Platelet
    activates the PI3K/Akt pathway during a first wave of aggregation, leading to thrombin generation and PAR‐1 activation, which evokes a second wave of aggregation...
    70 KB (8,489 words) - 17:12, 12 April 2024
  • Thumbnail for Proteinase-activated receptor 1
    known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the F2R gene. PAR1 is...
    19 KB (2,285 words) - 16:14, 23 April 2024