Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. The protein encoded by this gene belongs to the thrombospondin protein family...
6 KB (709 words) - 23:19, 27 March 2024
Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix...
6 KB (643 words) - 17:31, 26 December 2022
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric...
19 KB (2,343 words) - 10:57, 19 April 2024
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is...
12 KB (1,420 words) - 09:40, 14 January 2024
Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is...
9 KB (1,048 words) - 23:37, 3 March 2023
Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. The protein encoded by this gene belongs to the thrombospondin family...
8 KB (847 words) - 02:36, 29 November 2023
Plasmin (redirect from EC 3.4.21.7)
integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs...
15 KB (1,821 words) - 02:15, 10 March 2024
macrophages where the latent TGF-β complex is bound to CD36 via its ligand, thrombospondin-1 (TSP-1). Inflammatory stimuli that activate macrophages enhance the...
70 KB (8,485 words) - 08:12, 19 May 2024
CD47 (section Thrombospondin (TSP))
superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as...
36 KB (4,164 words) - 06:23, 20 May 2024
disease. MiR-27b also targets Thrombospondin-1, an antiangiogenic protein. Reduction in miR-27b increases Thrombospondin-1 levels, which decreases angiogenesis...
4 KB (415 words) - 04:07, 22 January 2021
ADAMTS5 (category EC 3.4.24)
A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. ADAMTS5...
12 KB (1,458 words) - 03:26, 26 November 2023
ADAMTS (category EC 3.4.24)
ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members...
5 KB (409 words) - 23:57, 18 February 2024
A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. This gene encodes a member...
13 KB (1,619 words) - 02:57, 28 November 2023
MMP2 (redirect from EC 3.4.24.24)
MMP2 has been shown to interact with: CCL7, THBS2, TIMP2, TIMP4, and Thrombospondin 1. GRCh38: Ensembl release 89: ENSG00000087245 – Ensembl, May 2017 GRCm38:...
24 KB (2,808 words) - 11:01, 11 April 2024
metalloproteinase with thrombospondin motifs 1 ADAMTS5: encoding enzyme a disintegrin and metalloproteinase with thrombospondin motifs 5 ADARB1: encoding...
33 KB (2,969 words) - 20:55, 20 April 2024
Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23. BMP4 is a member of the bone...
44 KB (5,478 words) - 12:38, 4 May 2024
phosphatidylserine receptor or by soluble (free-floating) receptors such as thrombospondin 1, GAS6, and MFGE8, which themselves then bind to other receptors on...
22 KB (2,451 words) - 18:51, 15 May 2024
common. Examples of TAF-derived ECM components include Tenascin and Thrombospondin-1 (TSP-1), which can be found in sites of chronic inflammation and carcinomas...
14 KB (1,677 words) - 11:44, 29 April 2024
activated after in vivo radiation exposure ROS. Activation by thrombospondin-1 Thrombospondin-1 (TSP-1) is a matricellular glycoprotein found in plasma of...
20 KB (2,412 words) - 15:51, 5 October 2022
type V, alpha 2 (COL5A2) Mucin 2 (MUC2) Mucin 5B (MUC5B) Thrombospondin 1 (THBS1) Thrombospondin 2 (THBS2) SCO-spondin (SSPO) CCN1: Cysteine-rich angiogenic...
5 KB (570 words) - 01:53, 31 December 2020
MMP9 (redirect from EC 3.4.24.35)
murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate interaction with matrix metalloproteinases...
25 KB (3,114 words) - 13:32, 5 January 2024
enzyme ADAMTS13 (acronym of "a disintegrin-like and metalloprotease with thrombospondin type 1 motif no. 13"). It is a metalloproteinase that cleaves VWF between...
17 KB (2,069 words) - 05:08, 4 January 2024
humans is encoded by the RSPO3 gene. This gene encodes a member of the thrombospondin type 1 repeat gene superfamily. In addition, the protein contains a...
4 KB (483 words) - 23:31, 3 March 2023
Cartilage oligomeric matrix protein (category Thrombospondins)
Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In...
11 KB (1,350 words) - 22:55, 18 January 2024
cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density...
44 KB (5,085 words) - 07:34, 19 May 2024
PLA2R autoantibodies. In 2014, a second autoantigen was discovered, the thrombospondin type 1 domain-containing 7A (THSD7A) system that might account for an...
22 KB (2,291 words) - 16:52, 1 November 2023
factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V, and von...
4 KB (349 words) - 11:47, 13 August 2023
MED. Lack of COMP was not compensated for by any other protein in the thrombospondin family. This study confirmed that the disease is not caused by reduced...
23 KB (2,399 words) - 04:17, 17 December 2023
ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene. This gene encodes a member of the...
6 KB (727 words) - 02:54, 28 November 2023
Aggrecanase (category EC 3.4.24)
that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family. Aggrecanases act on large proteoglycans known as aggrecans...
3 KB (296 words) - 16:35, 12 May 2024