U.S. Route 4 (US 4) is a 253-mile-long (407 km) United States Numbered Highway that runs from East Greenbush, New York, in the west to Portsmouth, New...

U.S. Route 4 (US 4) in the U.S. state of Vermont extends for 66.059 miles (106.312 km) between the New York state line at Fair Haven and the New Hampshire...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

U.S. Route 4 (US 4) in the state of New Hampshire runs for 106.834 miles (171.933 km) across the central and southern part of the state, stretching from...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 31E (US 31E) is the eastern parallel route for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky. US 31E begins as the Ellington...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 167 is a north-south United States Highway within the U.S. states of Louisiana and Arkansas. It runs for 500 miles (800 km) from Ash Flat, Arkansas...

U.S. Route 99 (US 99) was a main north–south United States Numbered Highway on the West Coast of the United States until 1964, running from Calexico,...

U.S. Route 4 (US 4) is a part of the United States Numbered Highway System that runs from East Greenbush, New York, to Portsmouth, New Hampshire. In the...

U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 58 (US 58) is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S...

U.S. Route 82 (US 82) is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England....

U.S. Route 283 is a spur of U.S. Route 83. It currently runs for 731 miles (1,175 km) from Brady, Texas at U.S. Route 87 to Lexington, Nebraska at U.S...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

U.S. Route 165 is a north–south United States highway spur of U.S. Highway 65. It currently runs for 412 miles (663 km) from U.S. Route 90 in Iowa, Louisiana...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66.), is a major east–west United...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate...

U.S. Route 21 or U.S. Highway 21 (US 21) is a major north–south United States Numbered Highway in the Southeastern United States that extends 394 miles...

U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas...

U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route...