• Thumbnail for Variant surface glycoprotein
    Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma...
    31 KB (3,678 words) - 21:00, 19 September 2023
  • Thumbnail for Trypanosoma brucei
    mammalian bloodstream forms are notable for their cell surface proteins, variant surface glycoproteins, which undergo remarkable antigenic variation, enabling...
    104 KB (12,253 words) - 06:44, 27 April 2024
  • Thumbnail for Glycoprotein
    Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein...
    28 KB (2,654 words) - 18:59, 28 November 2023
  • obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein which makes it difficult for the immune system to recognize the...
    4 KB (395 words) - 03:52, 29 November 2023
  • Thumbnail for P-glycoprotein
    P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family...
    35 KB (3,960 words) - 05:58, 29 April 2024
  • Thumbnail for Exon
    Rijsewijk FA, Borst P (June 1983). "The transposition unit of variant surface glycoprotein gene 118 of Trypanosoma brucei. Presence of repeated elements...
    13 KB (1,517 words) - 23:39, 2 April 2024
  • itself with a dense, homogeneous coat (~10^7 molecules) of the variant surface glycoprotein (VSG). In the early stages of invasion, the VSG coat is sufficient...
    25 KB (3,270 words) - 05:30, 15 April 2024
  • Thumbnail for Variants of SARS-CoV-2
    Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are viruses that, while similar to the original, have genetic changes that are...
    228 KB (21,044 words) - 20:05, 14 May 2024
  • Thumbnail for Glycoprotein IX
    membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane...
    8 KB (1,082 words) - 00:11, 14 May 2024
  • antigenic variation. This is achieved through the switching of its variant surface glycoprotein or VSG, a substance that coats the entire antigen. When this...
    14 KB (1,583 words) - 13:38, 30 December 2023
  • Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates. This family includes the mammalian hormones...
    11 KB (1,114 words) - 19:59, 4 April 2022
  • Thumbnail for Coronavirus spike protein
    of the spike glycoprotein is to mediate viral entry into the host cell by first interacting with molecules on the exterior cell surface and then fusing...
    75 KB (7,388 words) - 18:58, 4 May 2024
  • Thumbnail for Envelope glycoprotein GP120
    Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. It was discovered by Professors Tun-Hou Lee and Myron...
    21 KB (2,547 words) - 00:52, 4 December 2023
  • Thumbnail for Uromodulin
    Tamm–Horsfall protein (THP), is a zona pellucida-like domain-containing glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant...
    19 KB (2,208 words) - 21:29, 13 January 2024
  • with Prof. Piet Borst) in 1984. Cross was the first to isolate variant surface glycoproteins. https://www.rockefeller.edu/our-scientists/emeritus-facult...
    1 KB (111 words) - 13:13, 25 January 2024
  • Thumbnail for African trypanosomiasis
    trypanosomes are surrounded by a coat that is composed of variant surface glycoproteins (VSG). These proteins act to protect the parasite from any lytic...
    75 KB (6,849 words) - 09:21, 18 May 2024
  • Thumbnail for T-cell surface glycoprotein CD3 zeta chain
    T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans...
    5 KB (615 words) - 20:53, 3 March 2023
  • C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol...
    3 KB (249 words) - 14:23, 26 August 2023
  • Thumbnail for CD44
    CD44 (category Glycoproteins)
    The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded...
    27 KB (2,977 words) - 02:50, 10 February 2024
  • alleles designated LM and LN. The blood type is due to a glycoprotein present on the surface of a red blood cell (RBC), which behaves as a native antigen...
    7 KB (827 words) - 02:38, 23 June 2023
  • for variant surface antigens in trypanosomes. Nature. 1980;284:78-80. Boothroyd JC, Cross GA, Hoeijmakers JH, Borst P. A variant surface glycoprotein of...
    25 KB (3,526 words) - 01:02, 2 January 2024
  • Thumbnail for SARS-CoV-2 Omicron variant
    Omicron (B.1.1.529) is a variant of SARS-CoV-2 first reported to the World Health Organization (WHO) by the Network for Genomics Surveillance in South...
    207 KB (23,819 words) - 16:45, 15 April 2024
  • Thumbnail for Mucin short variant S1
    Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial...
    25 KB (2,926 words) - 10:12, 3 December 2023
  • disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which...
    41 KB (3,730 words) - 20:23, 12 May 2024
  • Thumbnail for Coagulation
    platelets, which bind directly to collagen with collagen-specific glycoprotein Ia/IIa surface receptors. This adhesion is strengthened further by von Willebrand...
    61 KB (5,968 words) - 20:54, 19 May 2024
  • Thumbnail for Histidine-rich glycoprotein
    Histidine-rich glycoprotein (HRG) is a glycoprotein that in humans is encoded by the HRG gene. The HRG protein is produced in the liver, and it could also...
    19 KB (2,243 words) - 19:50, 23 December 2023
  • Thumbnail for Hemagglutinin
    chains of cell-membrane glycoproteins and glycolipids. Influenza hemagglutinin: a homotrimeric glycoprotein that is found on the surface of influenza viruses...
    14 KB (1,566 words) - 04:57, 18 May 2024
  • Thumbnail for Respiratory syncytial virus
    envelope containing viral glycoproteins. There are 11 proteins, described further in the table below. Surface protein G (glycoprotein) is primarily responsible...
    102 KB (10,084 words) - 08:36, 14 May 2024
  • Thumbnail for ABO blood group system
    ABO blood group system (category Glycoproteins)
    glycoproteins contain polylactosamine chains that contains ABH substances attached and represent the majority of the antigens. The main glycoproteins...
    58 KB (5,850 words) - 03:34, 12 May 2024
  • Thumbnail for Dominance (genetics)
    ABO blood group system, chemical modifications to a glycoprotein (the H antigen) on the surfaces of blood cells are controlled by three alleles, two of...
    24 KB (2,496 words) - 21:43, 3 April 2024