ACTR2

ACTR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ACTR2, ARP2, ARP2 actin-related protein 2 homolog (yeast), ARP2 actin related protein 2 homolog, actin related protein 2, Actin related protein 2/3 complex subunit 2, p34-ARC, ARPC2, arp2/3 complex 34 kDa subunit, testis tissue sperm-binding protein Li 53e, actin related protein 2/3 complex, subunit 2, 34kDa, ARP2/3 protein complex subunit 34, actin-related protein 2/3 complex subunit 2
External IDs	OMIM: 604221; MGI: 1913963; HomoloGene: 4181; GeneCards: ACTR2; OMA:ACTR2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	65,271,253 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,062,913 bp
RNA expression pattern
	Top expressed in
	monocyte; ; trabecular bone; ; epithelium of nasopharynx; ; appendix; ; palpebral conjunctiva; ; lymph node; ; mucosa of sigmoid colon; ; bone marrow; ; visceral pleura; ; bone marrow cells;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; tibiofemoral joint; ; medial dorsal nucleus; ; dorsal striatum; ; trigeminal ganglion; ; globus pallidus; ; blood; ; nucleus of stria terminalis; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; actin filament binding; structural constituent of cytoskeleton; actin binding; ATP binding; cytoskeletal protein binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; focal adhesion; arp2/3 protein complex; cell cortex; actin cytoskeleton; actin cap; extracellular exosome; cytoskeleton; extracellular region; postsynaptic density; lamellipodium; azurophil granule lumen; ficolin-1-rich granule lumen; podosome core;
Biological process	cytosolic transport; Fc-gamma receptor signaling pathway involved in phagocytosis; actin filament organization; ephrin receptor signaling pathway; meiotic chromosome movement towards spindle pole; meiotic cytokinesis; establishment or maintenance of cell polarity; meiosis; asymmetric cell division; Arp2/3 complex-mediated actin nucleation; spindle localization; actin cytoskeleton organization; associative learning; response to immobilization stress; cellular response to trichostatin A; neutrophil degranulation; response to ethanol; cilium assembly; positive regulation of dendritic spine morphogenesis; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	10097
	66713
	ENSG00000138071
	ENSMUSG00000020152
	P61160
	P61161
	NM_005722; NM_001005386
	NM_146243; NM_001362899
	NP_001005386; NP_005713
	NP_666355; NP_001349828
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene.^[5]

The specific function of ACTR2 has not yet been determined. However, it is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.^[6]