ATPase ASNA1

ASNA1
Identifiers
Aliases	ASNA1, ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
External IDs	OMIM: 601913 MGI: 1928379 HomoloGene: 31513 GeneCards: ASNA1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,748,323 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,751,910 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; prefrontal cortex; ; right adrenal gland; ; left adrenal gland; ; islet of Langerhans; ; cingulate gyrus; ; left ventricle; ; body of stomach; ; nucleus accumbens;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; medulla oblongata; ; lip; ; entorhinal cortex; ; medial vestibular nucleus; ; cerebellar cortex; ; inferior colliculus; ; spermatid; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; hydrolase activity; ATP binding; arsenite transmembrane transporter activity; metal ion binding; transporter activity; ATPase-coupled transmembrane transporter activity;
Cellular component	cytoplasm; nucleolus; extracellular exosome; endoplasmic reticulum membrane; nucleus; endoplasmic reticulum; GET complex;
Biological process	IRE1-mediated unfolded protein response; inorganic anion transport; transport; posttranslational protein targeting to endoplasmic reticulum membrane; arsenite transport; protein insertion into ER membrane; tail-anchored membrane protein insertion into ER membrane;
	Sources:Amigo / QuickGO
Orthologs
	439
	56495
	ENSG00000198356
	ENSMUSG00000052456
	O43681
	O54984
	NM_004317
	NM_019652; NM_001357202; NM_001357203
	NP_004308; NP_001358417; NP_001358418
	NP_062626; NP_001344131; NP_001344132
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase ASNA1 also known as arsenical pump-driving ATPase and arsenite-stimulated ATPase is an enzyme that in humans is encoded by the ASNA1 gene.^[5]^[6]

Function[edit]

ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, arsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.^[6]

Interactions[edit]

ASNA1 is found to interact with FAM71D according to STRING^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.
^ ^a ^b "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".
^ "STRING 10".

External links[edit]

Human ASNA1 genome location and ASNA1 gene details page in the UCSC Genome Browser.

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I)". J. Biol. Chem. 273 (35): 22173–6. doi:10.1074/jbc.273.35.22173. PMID 9712828.
Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. 71 (1): 1–10. doi:10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.0.CO;2-#. PMID 9736449. S2CID 196597195.
Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I)". Somat. Cell Mol. Genet. 24 (5): 307–11. doi:10.1023/B:SCAM.0000007134.16744.8b. PMID 10696239. S2CID 11936516.
Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells". Cell. 128 (3): 577–87. doi:10.1016/j.cell.2006.12.031. PMID 17289575. S2CID 2120123.
Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–59. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884272-5] Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.

[entrez-6] "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".

[7] "STRING 10".

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