Andrew P. Carter

Andrew P Carter
NationalityBritish
Alma mater
AwardsEMBO Member (2016)
Scientific career
Fields
Institutions
Doctoral advisorVenki Ramakrishnan
Other academic advisorsRon Vale
Websitewww2.mrc-lmb.cam.ac.uk/groups/cartera/

Andrew P. Carter is a British structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge, UK. He is known for his work on the microtubule motor dynein.[1][2][3][4]

Education[edit]

Carter studied Biochemistry at the University of Oxford, graduating in 1999.[5] He obtained a PhD in 2003 from the MRC Laboratory of Molecular Biology where he worked with Venki Ramakrishnan on the ribosome. He was a member of the team in Ramakrishnan's lab that solved the first X-ray crystal structure of the small (30S) ribosomal subunit.[6] Carter also determined structures of 30S bound to antibiotics[7] and bound to the initiation factor IF1.[8] Ramakrishnan shared the Nobel prize in Chemistry for the team's work on the 30S.[9]

Career and research[edit]

Carter was a post-doc in Ron Vale's lab[10] at University of California, San Francisco from 2003 to 2010. During his post-doc, he studied the molecular motor protein, dynein using X-ray crystallography and single molecule fluorescence microscopy.[11][12]

He became a group leader at MRC Laboratory of Molecular Biology in Cambridge in 2010 where he uses X-ray crystallography, electron microscopy, and single molecule microscopy assays to understand how dynein transports cargo. His group solved X-ray crystal structures of the dynein motor domain showing how it generates force to pull cargos along microtubules[1] and reconstituted a recombinant dynein, showing how its processive movement is activated by cofactors/cargo adaptors.[13] His group used cryoEM to solve the structure of dynein's cofactor dynactin[2] and the full length dynein complex.[3] They showed how dynein and dynactin come together in the presence of cargos and how this activates transport.

Grants, awards and honours[edit]

References[edit]

  1. ^ a b Schmidt, Helgo; Zalyte, Ruta; Urnavicius, Linas; Carter, Andrew P. (19 February 2015). "Structure of human cytoplasmic dynein-2 primed for its power stroke". Nature. 518 (7539): 435–438. Bibcode:2015Natur.518..435S. doi:10.1038/nature14023. ISSN 1476-4687. PMC 4336856. PMID 25470043.
  2. ^ a b Urnavicius, Linas; Zhang, Kai; Diamant, Aristides G.; Motz, Carina; Schlager, Max A.; Yu, Minmin; Patel, Nisha A.; Robinson, Carol V.; Carter, Andrew P. (27 March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. ISSN 1095-9203. PMC 4413427. PMID 25814576.
  3. ^ a b Zhang, Kai; Foster, Helen E.; Rondelet, Arnaud; Lacey, Samuel E.; Bahi-Buisson, Nadia; Bird, Alexander W.; Carter, Andrew P. (15 June 2017). "Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated". Cell. 169 (7): 1303–1314.e18. doi:10.1016/j.cell.2017.05.025. ISSN 1097-4172. PMC 5473941. PMID 28602352.
  4. ^ Urnavicius, Linas; Lau, Clinton K.; Elshenawy, Mohamed M.; Morales-Rios, Edgar; Motz, Carina; Yildiz, Ahmet; Carter, Andrew P. (7 February 2018). "Cryo-EM shows how dynactin recruits two dyneins for faster movement". Nature. 554 (7691): 202–206. Bibcode:2018Natur.554..202U. doi:10.1038/nature25462. ISSN 1476-4687. PMC 5988349. PMID 29420470.
  5. ^ "2012 Alumni Lecture celebrating Oxford Biochemistry graduate success Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Archived from the original on 13 August 2018. Retrieved 26 August 2018.
  6. ^ Wimberly, B. T.; Brodersen, D. E.; Clemons, W. M.; Morgan-Warren, R. J.; Carter, A. P.; Vonrhein, C.; Hartsch, T.; Ramakrishnan, V. (21 September 2000). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. Bibcode:2000Natur.407..327W. doi:10.1038/35030006. ISSN 0028-0836. PMID 11014182. S2CID 4419944.
  7. ^ Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Wimberly, B. T.; Ramakrishnan, V. (21 September 2000). "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics". Nature. 407 (6802): 340–348. Bibcode:2000Natur.407..340C. doi:10.1038/35030019. ISSN 0028-0836. PMID 11014183. S2CID 4408938.
  8. ^ Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Hartsch, T.; Wimberly, B. T.; Ramakrishnan, V. (19 January 2001). "Crystal structure of an initiation factor bound to the 30S ribosomal subunit". Science. 291 (5503): 498–501. Bibcode:2001Sci...291..498C. doi:10.1126/science.1057766. ISSN 0036-8075. PMID 11228145.
  9. ^ "Venkatraman Ramakrishnan - Nobel Lecture: Unraveling the Structure of the Ribosome". NobelPrize.org. Retrieved 26 August 2018.
  10. ^ "Carter". valelab.ucsf.edu. Retrieved 25 August 2018.
  11. ^ Carter, Andrew P.; Garbarino, Joan E.; Wilson-Kubalek, Elizabeth M.; Shipley, Wesley E.; Cho, Carol; Milligan, Ronald A.; Vale, Ronald D.; Gibbons, I. R. (12 December 2008). "Structure and functional role of dynein's microtubule-binding domain". Science. 322 (5908): 1691–1695. Bibcode:2008Sci...322.1691C. doi:10.1126/science.1164424. ISSN 1095-9203. PMC 2663340. PMID 19074350.
  12. ^ Carter, Andrew P.; Cho, Carol; Jin, Lan; Vale, Ronald D. (4 March 2011). "Crystal structure of the dynein motor domain". Science. 331 (6021): 1159–1165. Bibcode:2011Sci...331.1159C. doi:10.1126/science.1202393. ISSN 1095-9203. PMC 3169322. PMID 21330489.
  13. ^ Schlager, Max A.; Hoang, Ha Thi; Urnavicius, Linas; Bullock, Simon L.; Carter, Andrew P. (1 September 2014). "In vitro reconstitution of a highly processive recombinant human dynein complex". The EMBO Journal. 33 (17): 1855–1868. doi:10.15252/embj.201488792. ISSN 1460-2075. PMC 4158905. PMID 24986880.
  14. ^ "LMB Student Prize - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. Retrieved 26 August 2018.
  15. ^ "Agouron Institute | Fellowships". agi.org. Retrieved 26 August 2018.
  16. ^ Cambridge, Clare College. "Dr Andrew Carter - Clare College Cambridge". www.clare.cam.ac.uk. Retrieved 25 August 2018.
  17. ^ adit. "22 young group leaders recognized as EMBO Young Investigators". EMBO. Retrieved 26 August 2018.
  18. ^ a b "Investigator Awards in Science: people we've funded | Wellcome". wellcome.ac.uk. Retrieved 26 August 2018.
  19. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 26 August 2018.
  20. ^ "58 life science researchers elected as new EMBO Members". EMBO. Archived from the original on 15 August 2016. Retrieved 26 August 2018.
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