COX7A2

COX7A2
Identifiers
Aliases	COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2
External IDs	OMIM: 123996 MGI: 1316715 HomoloGene: 36082 GeneCards: COX7A2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	75,250,323 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	79,667,160 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pancreatic ductal cell; ; right ventricle; ; Brodmann area 23; ; sperm; ; prefrontal cortex; ; jejunal mucosa; ; palpebral conjunctiva; ; rectum; ; oral cavity;
	Top expressed in
	facial motor nucleus; ; medial ganglionic eminence; ; digastric muscle; ; otic placode; ; temporal muscle; ; sternocleidomastoid muscle; ; epithelium of stomach; ; triceps brachii muscle; ; intercostal muscle; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; cytochrome-c oxidase activity;
Cellular component	mitochondrial inner membrane; membrane; mitochondrion; mitochondrial respirasome;
Biological process	proton transmembrane transport; electron transport chain; regulation of oxidative phosphorylation; mitochondrial respirasome assembly;
	Sources:Amigo / QuickGO
Orthologs
	1347
	12866
	ENSG00000112695
	ENSMUSG00000032330
	P14406
	P48771
	NM_001865
	NM_009945
	NP_001856; NP_001353221; NP_001353222
	NP_034075
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.^[5]^[6]^[7]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.

In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112695 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
^ Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH (Aug 1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene". Genome. 40 (3): 318–24. doi:10.1139/g97-044. PMID 9202412.
^ ^a ^b "Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)".

External links[edit]

Human COX7A2 genome location and COX7A2 gene details page in the UCSC Genome Browser.

Further reading[edit]

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. ISBN 978-0-12-540061-9. PMID 9752724.
Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–9. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID 1309697.
Fabrizi GM, Rizzuto R, Nakase H, et al. (1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res. 17 (17): 7107. doi:10.1093/nar/17.17.7107. PMC 318441. PMID 2550906.
Taanman JW, Hall RE, Tang C, et al. (1993). "Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies". Biochim. Biophys. Acta. 1225 (1): 95–100. doi:10.1016/0925-4439(93)90128-n. PMID 8241294.
Merante F, Ling M, Duncan AM, et al. (1997). "Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes". Genome. 40 (3): 325–31. doi:10.1139/g97-045. PMID 9202413.
Hüttemann M, Mühlenbein N, Schmidt TR, et al. (2000). "Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene". Biochim. Biophys. Acta. 1492 (1): 252–8. doi:10.1016/s0167-4781(00)00087-7. PMID 11004498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112695 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1327965-5] Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.

[pmid9202412-6] Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH (Aug 1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene". Genome. 40 (3): 318–24. doi:10.1139/g97-044. PMID 9202412.

[entrez-7] "Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)".

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