Protein-coding gene in the species Homo sapiens
CXXC1 Identifiers Aliases CXXC1 , 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1External IDs OMIM : 609150 MGI : 1921572 HomoloGene : 32221 GeneCards : CXXC1 Wikidata
CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene .[5] [6] [7]
Proteins that contain a CXXC motif within their DNA-binding domain , such as CXXC1, recognize CpG sequences and regulate gene expression .[6]
See also [ edit ] References [ edit ] ^ a b c GRCh38: Ensembl release 89: ENSG00000154832 – Ensembl , May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024560 – Ensembl , May 2017 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun . 271 (2): 305–310. doi :10.1006/bbrc.2000.2614 . PMID 10799292 . ^ a b Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1" . Mol Cell Biol . 20 (6): 2108–2121. doi :10.1128/MCB.20.6.2108-2121.2000 . PMC 110827 . PMID 10688657 . ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)" . External links [ edit ] Further reading [ edit ] Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–435. doi :10.1101/gr.GR1547R . PMC 311072 . PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–292. doi :10.1093/embo-reports/kvd058 . PMC 1083732 . PMID 11256614 . Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein" . J. Biol. Chem . 276 (48): 44669–44676. doi :10.1074/jbc.M107179200 . PMID 11572867 . Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development" . Mol. Cell. Biol . 21 (22): 7601–7606. doi :10.1128/MCB.21.22.7601-7606.2001 . PMC 99931 . PMID 11604496 . Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals" . J. Biol. Chem . 277 (44): 42259–42267. doi :10.1074/jbc.M205054200 . PMID 12200428 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–1625. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex" . J. Biol. Chem . 280 (50): 41725–41731. doi :10.1074/jbc.M508312200 . PMID 16253997 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–814. doi :10.1016/j.cell.2006.03.032 . PMID 16713569 . S2CID 13709685 . Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol . 26 (2): 80–90. doi :10.1089/dna.2006.0535 . PMID 17328666 .