DOTFM-NDEPA

DOTFM-NDEPA
Clinical data
Other namesNDEPA-DOTFM; "Compound ko1"[1]
Drug classPossible serotonin 5-HT2A receptor modulator[1]
ATC code
  • None
Identifiers
CAS Number
Chemical and physical data
FormulaC19H29F3N2O3
Molar mass390.447 g·mol−1
3D model (JSmol)
  • C(F)(F)(F)C1C=C(C(=CC=1OC)CC(C)N(CCC(=O)N(CC)CC)[H])OC
  • InChI=1S/C19H29F3N2O3/c1-6-24(7-2)18(25)8-9-23-13(3)10-14-11-17(27-5)15(19(20,21)22)12-16(14)26-4/h11-13,23H,6-10H2,1-5H3
  • Key:XQPSNZUNPOQENQ-UHFFFAOYSA-N

DOTFM-NDEPA is a chemical compound of the phenethylamine, DOx, and NDEPA families.[1] It is the N-(N,N-diethylpropylamide) (NDEPA) derivative of the psychedelic drug DOTFM.[1] The drug can also be thought of as a derivative of DOTFM with an LSD-like N,N-diethylamide moiety.[1] A quantitative structure–activity relationship (QSAR) predicted that DOTFM-NDEPA would bind with high affinity to the serotonin 5-HT2A receptor.[1] Its predicted affinity (Ki) was 22 nM.[1] DOTFM-NDEPA was first described in the scientific literature by 1999.[1]

See also

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References

[edit]
  1. ^ a b c d e f g h Schulze-Alexandru M, Kovar KA, Vedani A (1999). "Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances" (PDF). Quantitative Structure-Activity Relationships. 18 (6): 548–560. doi:10.1002/(SICI)1521-3838(199912)18:6<548::AID-QSAR548>3.0.CO;2-B. ISSN 0931-8771. Retrieved 6 July 2025.



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