\documentclass[12pt,border=5pt,tikz,class=scrartcl,multi=false]{standalone} \usepackage{times} \usepackage[T1]{fontenc} \usepackage[latin1]{inputenc} \usepackage{mathtools,amssymb,siunitx} \usepackage{pgfplots} \pgfplotsset{compat=1.13} \usepackage{circuitikz} \usepackage{carbohydrates} \usepackage{gensymb} \usepackage{chemfig,chemmacros} \renewcommand*{\familydefault}{\sfdefault} \renewcommand*\printatom[1]{\ensuremath{\mathsf{#1} } } \setatomsep{2em} \setdoublesep{.6ex} \setarrowdefault{,1,ultra thick} \usetikzlibrary{positioning,calc,arrows,fit,backgrounds,decorations,shapes,matrix} \pagestyle{empty} \thispagestyle{empty} \begin{document} \begin{tikzpicture}[ >=stealth', line width=3mm, enzyme/.style={text=blue,font=\itshape,minimum width=2cm,align=center}, steps/.style={minimum width=2cm, align=center,font=\bfseries}, info/.style={minimum width=2cm, align=center,font=\bfseries,text=brown}, % every node/.style={text width=7mm,text centered} % myarrows/.style={line width=.6mm,draw=red,-triangle 45,postaction={draw=red,line width=1.5mm, shorten >=2mm, -} } ] \node[steps,font=\normalfont] (a1) {Acetyle-CoA}; \node[steps,font=\normalfont] at ($(a1)-(0,2.5)$) (a2) {Acetoacetyl-CoA}; \node[steps] at ($(a1)+(7,0)$) (a3) {3-hydroxy-3-methylglutaryl-CoA\\(HMG-CoA)}; \node[steps] at ($(a3)-(0,2.5)$) (a4) {Mevalonic acid}; \node[steps] at ($(a4)-(0,2.5)$) (a5) {Mevalonate-5-phosphate}; \node[steps] at ($(a5)-(0,2.5)$) (a6) {Mevalonate-5-pyrophosphate}; \node[steps] at ($(a6)-(0,2.5)$) (a7) {Isopentenyl-5-pyrophosphate {\normalfont(PP)} }; \node[steps] at ($(a7)-(0,2.5)$) (a8) {Geranyl PP}; \node[steps] at ($(a8)-(0,2.5)$) (a9) {Farnesyl-PP}; \node[steps] at ($(a9)-(0,2.5)$) (a10) {Squalene}; \node[steps] at ($(a10)-(0,2.5)$) (a11) {2,3-oxidosqualene}; \node[steps] at ($(a11)-(0,2.5)$) (a12) {Lanosterol}; \node[steps,text=green!70!black] at ($(a12)-(0,2.5)$) (a13) {CHOLESTEROL}; \node[steps] at ($(a7)-(7,0)$) (a14) {Dimethylallyl-PP}; \node[steps] at ($(a9)-(6.75,0)$) (a15) {Geranylgeranyl-PP}; \node[steps,text=green!70!black] at ($(a15)-(0,5)$) (a16) {PRENYLATED\\PROTEINS}; \node[steps,text=green!70!black] at ($(a16)+(3,0)$) (a17) {HEME A \\DOLICHOL\\UBIQUINON}; \draw [->, very thick] (a1) -- node[left,enzyme] {Thiolase} (a2); \draw [->, very thick] (a1) -- (a3); \draw [->, very thick] (a2) -- node[below,enzyme] {HMG-CoA\\synthase} (a3); \draw [->, very thick] (a3) -- node[right,enzyme] {HMG-CoA reductase} node[below right=1mm and 23mm,info] {STATINS} (a4); \draw [->, very thick] (a4) -- node[left=7mm] (side1) {ATP} node[right,enzyme] {Mevalonate kinase} (a5); \draw [->, very thick] (side1.east) to [out=0,in=90] (a5.north); \draw [->, very thick] (a5) -- node[right,enzyme] {Phosphomevalonate kinase} (a6); \draw [->, very thick] (a6) -- node[left=7mm](side2){--\ch{CO2} } node[right,enzyme] {Mevalonate-5-pyrophosphate\\decarboxylase} (a7); \draw [->, very thick] (a6.south) to [out=-90,in=0] (side2.east); \draw [->, very thick] (a7) -- node[right,enzyme] {Farnesyl-PP synthase} node[below right=1mm and 10mm,info] {BISPHOSPHONATES} (a8); \draw [->, very thick] (a8) -- node[right,enzyme] {Farnesyl-PP synthase} node[below right=1mm and 10mm,info] {BISPHOSPHONATES} (a9); \draw [->, very thick] (a9) -- node[right,enzyme] {Squalene synthase} (a10); \draw [->, very thick] (a10) -- node[right,enzyme] {Squalene\\monooxygenase} (a11); \draw [->, very thick] (a11) -- node[left=7mm](side3){\ch{NADPH} } node[right,enzyme] {Squalene\\epoxydase} (a12); \draw [->, very thick] (side3.east) to [out=0,in=90] (a12.north); \draw [->, very thick, dotted] (a12) -- node[right,enzyme] {19 reactions} (a13); \draw [->, very thick] (a7) -- node[above,enzyme] {Isopentenyl-PP\\isomerase} (a14); \draw [->, very thick] (a14) -- (a8); \draw [->, very thick] (a14) -- (a9); \draw [->, very thick] (a7) -- (a15); \draw [->, very thick] (a9) -- node[enzyme] {Geranylgeranyl-PP\\synthase} (a15); \draw [->, very thick] (a15) -- (a16); \draw [->, very thick] (a9) -- (a16); \draw [->, very thick] (a9) -- (a17); \end{tikzpicture} \end{document}