Nº | Picture | Name | President | Term in office |
Holders of the title "Wife of the President" |
1º | | Mercedes Jijón | Juan José Flores | 1830–1834 |
2º | | Baltazara Calderón de Rocafuerte | Vicente Rocafuerte y Bejarano | 1835–1839 |
(1º) | | Mercedes Jijón | Juan José Flores | 1839–1845 |
| | María Rosa Icaza | José Joaquín de Olmedo (Head of the Provisional Government) | 1845–1845 |
3º | | Juana Andrade Fuente Fría | Vicente Ramón Roca | 1845–1849 |
| | Carmen Salinas de la Vega | Manuel de Ascazubi y Matheu (Vice-president, in charge of the Government) | 1849–1850 |
4º | | Tomasa Carbo y Noboa | Diego Noboa | 1850–1851 |
5º | | Teresa Jado | José María Urvina y Viteri | 1851–1856 |
6º | | Carmen de Santistevan y Avilés | Francisco Robles Garcia | 1856–1859 |
7º | | Rosa Ascázubi y Matheu | Gabriel García Moreno | 1859–1865 |
| | Widower | Rafael Carvajal (Vice-president, in charge of the Government) | 1865–1865 |
8º | | María Antonia Andrade | Jeronimo Carrion y Palacio | 1865–1867 |
| | Juana Arteta y Garzon | Pedro José de Arteta (Vice-president, in charge of the Government) | 1867–1868 |
| | Single | Javier Espinosa y Espinosa | 1868–1869 |
| | Mariana del Alcázar y Ascasubi | Gabriel García Moreno (Interim President) | 1869–1869 |
| | Carmen Salinas de la Vega | Manuel de Ascásubi y Matheu (Interim constitutional President) | 1869–1869 |
9º | | Mariana del Alcazar y Ascasubi | Gabriel García Moreno | 1869–1875 |
| | | Francisco Xavier León y Franco (Vice-president, in charge of the Government) | 1875–1875 |
| | Isabel Valdivieso y Carcelén de Guevara | José Javier Eguiguren (Min. of Finance, in charge of the Government) | 1875–1875 |
10º | | Rosa Lucía Moscoso Cardenas | Antonio Borrero y Cortázar | 1875–1876 |
11º | | Marieta de Veintemilla | Ignacio de Veintemilla y Villacis | 1876–1883 |
| | Jesús Dávila Heredia | Luis Cordero Crespo (1st President of the Pentavirato) | 1883 |
| | Antonia Chiriboga y Muñoz | Rafael Pérez Pareja (2nd President of the Pentavirato) | 1883 |
12º | | Pastoriza Marquez de la Plata y Plaza | José María Plácido Caamaño | 1883–1888 |
| | Leticia Escobar y Salvador | Pedro José Cevallos (Vice-president, in charge of the Government) | 1895–1895 |
13º | | Leonor Ruiz de Apodaca | Antonio Flores Jijón | 1888–1892 |
| | Widower (Jesús Davila Heredia) | Luis Cordero Crespo | 1892–1895 |
| | Manuela Quiñones Perez | Vicente Lucio Salazar (Vice-president, in charge of the Government) | 1895–1895 |
14º | | Ana Paredes Arosemena | Eloy Alfaro Delgado | 1895–1901 |
15º | | Avelina Lasso | Leónidas Plaza y Gutiérrez | 1901–1905 |
16º | | Carmen Coello Alvarez | Lizardo García Sorroza | 1905–1906 |
(14º) | | Ana Paredes Arosemena | Eloy Alfaro Delgado | 1906–1911 |
| | Rosa Elena Larrea y Gomez de la Torre | Carlos Freile Zaldumbide (President of the Senate, in charge of the Government) | 1911–1911 |
17º | | Lastenia Gamarra Menéndez | Emilio Estrada Carmona | 1911 |
| | Rosa Elena Larrea y Gomez de la Torre | Carlos Freile Zaldumbide (President of the Senate, in charge of the Government) | 1911–1912 |
| | Victoria Malo German | Francisco Andrade Marín (President of the Congress, in charge of the Government) | 1912–1912 |
| | Piedad Roca Marcos | Alfredo Baquerizo Moreno (President of the Senate, in charge of the Government) | 1912–1912 |
(15º) | | Avelina Lasso | Leónidas Plaza y Gutiérrez | 1912–1916 |
18º | | Piedad Roca Marcos | Alfredo Baquerizo Moreno | 1916–1920 |
19º | | Esther Concha Torres | José Luis Tamayo | 1920–1924 |
20º | | Victoria Monsalve Cardenas | Gonzalo Córdova y Rivera | 1924–1925 |
| | Does not exist | Provisional Government | 1925–1926 |
21º | | Laura Carbo Núñez | Isidro Ayora Cueva | 1926–1931 |
| | Lucy Lopez y Williams | Luis Larrea Alba (Secretary of State, in charge of the Government) | 1931–1931 |
| | Piedad Roca Marcos | Alfredo Baquerizo Moreno (President of the Senate, in charge of the Government) | 1931–1932 |
| | Manuela Gomez de la Torre y Nájera | Carlos Freile Larrea (Secretary of State, in charge of the Government) | 1932–1932 |
| | Maria Elena Valenzuela y Plaza | Alberto Guerrero Martínez (President of the Senate, in charge of the Government) | 1932–1932 |
22º | | Francisca Torres Lascano | Juan de Dios Martínez Mera | 1932–1933 |
| | | Abelardo Montalvo (President of the Senate, in charge of the Government) | 1933–1934 |
23º | | Esther Silva Burbano | José María Velasco Ibarra | 1934–1935 |
| | Single | Antonio Pons (Secretary of State, in charge of the Government) | 1935–1935 |
| | Adelina Espinosa García | Federico Páez (Interim President) | 1935–1937 |
| | Mariana Calderón Alava | Alberto Enríquez Gallo (Supreme Chief) | 1937–1938 |
| | Ana Maria Bustamante | Manuel María Borrero (Interim President) | 1938 |
24º | | Judith Perez Davalos | Aurelio Mosquera Narváez | 1938–1939 |
| | Elena Yerovi Matheu | Carlos Arroyo del Río (President of the Senate, in charge of the Government) | 1939 |
| | Rosario Galarza Arizaga | Andres Fernandez de Cordova (President of the Congress, in charge of the Government) | 1939–1940 |
| | | Julio Enrique Moreno (President of the Senate, in charge of the Government) | 1940 |
25º | | Elena Yerovi Matheu | Carlos Arroyo del Río | 1940–1944 |
| | Does not exist | Provisional Government | 1944 |