KIAA1958

KIAA1958
Identifiers
AliasesKIAA1958
External IDsOMIM: 617390 HomoloGene: 136743 GeneCards: KIAA1958
Orthologs
SpeciesHumanMouse
Entrez

158405

n/a

Ensembl

ENSG00000165185

n/a

UniProt

Q8N8K9

n/a

RefSeq (mRNA)

NM_001287036
NM_001287038
NM_133465

n/a

RefSeq (protein)

NP_001273965
NP_001273967
NP_597722

n/a

Location (UCSC)Chr 9: 112.49 – 112.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene.[3] Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.

Gene[edit]

KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597.[4] Its mRNA has 2683 bp.[3] The gene has these neighbors on chromosome 9:

KIAA1958 gene neighbors

HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding.[5]

C9orf147: Chromosome 9 open reading frame 147 has an unknown function.[6]

C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability.[7]

SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding.[8]

Expression[edit]

KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST.[9] The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors.[9] Data from NCBI GEO Profile[10] shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells.[11] KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells[11] and both the embryonic stem cell and the pluripotent stem cell.[11]

Protein[edit]

KIAA1958 predicted phosphorylated sites

KIAA1958 is composed of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375.[12] Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.

Structure[edit]

PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein.[13] According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.

Interactions[edit]

There is no known proof that KIAA1958 interacts with any other proteins at this time.[14]

Homology[edit]

Genus and Species Common Name Accession Number Seq. Length Seq. Identity Seq. Similarity
Pan troglodytes Chimpanzee XM_528391 7945 bp 99% 99%
Mus musculus Mouse BAC38268 719 a 97% 98%
Callithrix jacchus Common marmoset XM_002743204 2346bp 97% 82%
Pongo abelii Sumatran Orangutan XM_002820112 1120bp 96% 4%
Sus scrofa Wild boar XM_003122070 2502 bp 93% 81%
Ailuropoda melanoleuca Giant Panda XM_002925938 2151 bp 85% 91%
Nomascus leucogenys White cheeked gibbon XM_003263945 950 bp 93% 5%
Oryctolagus cuniculus European rabbit XM_002707990 2223 bp 93% 43%
Loxodonta africana African bush elephant XM_003407521 2388 bp 93% 80%
Cricetulus griseus Chinese hamster XM_003505508 2534 bp 92% 42%
Equus caballus Horse XM_001916302 2536 bp 91% 93%
Bos taurus Cow XM_876102.5 2480 bp 91% 81%
Rattus norvegicus Rat XM_002726532 1364 bp 91% 36%
Cavia porcellus Guinea pig XM_003463791 2217 bp 91% 43%
Monodelphis domestica Opossum XM_001375976 2217 bp 78% 41%
Branchiostoma floridae Lancelet XP_002611438 719 a 29% 48%
Amphimedon queenslandica Sponge XP_003390994 388 a 25% 48%
Acyrthosiphon pisum Pea aphid XP_001943720 1197 aa 24% 43%
Oikopleura dioica Chordate CBY34656 629 a 22% 43%
Ciona intestinalis Vase tunicate XP_002125964 1004 aa 23% 43%
Xenopus (silurana) tropicalis Western Clawed frog AAI61073 679 a 23% 43%
Halocynthia roretzi Sea pineapple BAB40645 980 a 23% 45%

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165185 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Homo sapiens KIAA1958 (KIAA1958), mRNA". NCBI. Retrieved 20 April 2012.
  4. ^ "Homo sapiens gene KIAA1958, encoding KIAA1958". AceView. Retrieved 19 April 2012.
  5. ^ "Q6YN16 (HSDL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot". UniProt. Retrieved 1 May 2012.
  6. ^ "Homo sapiens gene C9orf147, encoding chromosome 9 open reading frame 147". AceView. Retrieved 1 May 2012.
  7. ^ "Q9NRY2 (SOSSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  8. ^ "Q5VWJ9 (SNX30_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
  9. ^ a b "Unigene EST profile". Unigene. Retrieved 8 May 2012.
  10. ^ "Geo Profiles". NCBI. Retrieved 28 April 2012.
  11. ^ a b c "Gene Expression Profiles". Embl-Ebi. Retrieved 8 May 2012.
  12. ^ "Biology WorkBench". SDSC. Retrieved 3 May 2012.
  13. ^ "Biology Workbench". SDSC Biology WorkBench. Retrieved 28 April 2012.
  14. ^ "Protein Interactions". String. Retrieved 7 May 2012.

Further reading[edit]

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