Olfactomedin 1

OLFM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XAT
Identifiers
Aliases	OLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDs	OMIM: 605366 MGI: 1860437 HomoloGene: 8612 GeneCards: OLFM1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	135,121,180 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,120,748 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 10; ; frontal pole; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex; ; Brodmann area 46; ; Brodmann area 23; ; Brodmann area 9; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; hippocampus proper; ; primary motor cortex; ; prefrontal cortex; ; piriform cortex; ; subiculum; ; cerebellar cortex; ; entorhinal cortex; ; Region I of hippocampus proper; ; medial dorsal nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell junction; axon; neuronal cell body; perikaryon; axonal growth cone; synapse; cell projection; endoplasmic reticulum; extracellular space;
Biological process	multicellular organism development; atrioventricular valve formation; neuronal signal transduction; positive regulation of gene expression; regulation of axon extension; positive regulation of epithelial to mesenchymal transition; negative regulation of gene expression; nervous system development; cardiac epithelial to mesenchymal transition; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	10439
	56177
	ENSG00000130558
	ENSMUSG00000026833
	Q99784
	O88998
	NM_058199; NM_001282611; NM_001282612; NM_006334; NM_014279
	NM_001038612; NM_001038613; NM_001038614; NM_019498
	NP_001269540; NP_001269541; NP_006325; NP_055094
	NP_001033701; NP_001033702; NP_001033703; NP_062371
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene.^[5]^[6] The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".^[7]

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.^[6]

Cancer[edit]

OLFM1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026833 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (May 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
^ ^a ^b "Entrez Gene: OLFM1 olfactomedin 1".
^ Anholt RR (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.
^ ^a ^b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading[edit]

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677. S2CID 25119660.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026833 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039501-5] Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (May 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.

[entrez-6] "Entrez Gene: OLFM1 olfactomedin 1".

[7] Anholt RR (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.

[Rotondo_2015-8] Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

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