THOP1

THOP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1S4B, 2O36

Identifiers

THOP1, EP24.15, MEPD_HUMAN, MP78, TOP, thimet oligopeptidase 1

External IDs

OMIM: 601117 MGI: 1354165 HomoloGene: 55726 GeneCards: THOP1

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	2,785,503 bp^[1]
Band	19p13.3	End	2,815,807 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C1\|10 39.72 cM	Start	80,905,869 bp^[2]
Band	10 C1\|10 39.72 cM	End	80,918,393 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

anterior pituitary

gastrocnemius muscle

prefrontal cortex

cingulate gyrus

ganglionic eminence

Brodmann area 9

nucleus accumbens

caudate nucleus

amygdala

Top expressed in

spermatid

spermatocyte

esophagus

seminiferous tubule

lip

internal carotid artery

external carotid artery

lacrimal gland

somite

secondary oocyte

More reference expression data


More reference expression data

Gene ontology
Molecular function	peptide binding peptidase activity hydrolase activity metallopeptidase activity metal ion binding metalloendopeptidase activity
Cellular component	cytoplasm mitochondrial intermembrane space cytosol
Biological process	proteolysis peptide metabolic process protein polyubiquitination
Sources:Amigo / QuickGO

Species

Human

Mouse


7064


50492


ENSG00000172009


ENSMUSG00000004929


P52888


Q8C1A5

RefSeq (mRNA)


NM_003249


NM_022653

RefSeq (protein)


NP_003240


NP_073144

Location (UCSC)

Chr 19: 2.79 – 2.82 Mb

Chr 10: 80.91 – 80.92 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172009 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Torres MP, Prange C, Lennon G (Dec 1998). "Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease". Genomics. 53 (2): 239–40. doi:10.1006/geno.1998.5487. PMID 9790774.
^ "Entrez Gene: THOP1 thimet oligopeptidase 1".

Further reading[edit]

Thompson A, Huber G, Malherbe P (1995). "Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide". Biochem. Biophys. Res. Commun. 213 (1): 66–73. doi:10.1006/bbrc.1995.2099. PMID 7639763.
Papastoitsis G, Siman R, Scott R, Abraham CR (1994). "Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments". Biochemistry. 33 (1): 192–9. doi:10.1021/bi00167a025. PMID 8286339.
Dando PM, Brown MA, Barrett AJ (1993). "Human thimet oligopeptidase". Biochem. J. 294 (Pt 2): 451–7. doi:10.1042/bj2940451. PMC 1134475. PMID 8373360.
Meckelein B, de Silva HA, Roses AD, et al. (1997). "Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus". Genomics. 31 (2): 246–9. doi:10.1006/geno.1996.0041. PMID 8824811.
Crack PJ, Wu TJ, Cummins PM, et al. (1999). "The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane". Brain Res. 835 (2): 113–24. doi:10.1016/S0006-8993(99)01494-8. PMID 10415366. S2CID 23769423.
Pineau C, McCool S, Glucksman MJ, et al. (2000). "Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes". J. Cell Sci. 112 (20): 3455–62. doi:10.1242/jcs.112.20.3455. PMID 10504294.
Ferro ES, Tullai JW, Glucksman MJ, Roberts JL (1999). "Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15)". DNA Cell Biol. 18 (10): 781–9. doi:10.1089/104454999314926. hdl:11449/37910. PMID 10541437.
Tullai JW, Cummins PM, Pabon A, et al. (2001). "The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation". J. Biol. Chem. 275 (47): 36514–22. doi:10.1074/jbc.M001843200. PMID 10969067.
Molina HM, Carmona AK, Kouyoumdjian M, Borges DR (2000). "Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase". Life Sci. 67 (5): 509–20. doi:10.1016/S0024-3205(00)00650-0. PMID 10993116.
Saric T, Beninga J, Graef CI, et al. (2001). "Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase". J. Biol. Chem. 276 (39): 36474–81. doi:10.1074/jbc.M105517200. PMID 11479311.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gioli-Pereira L, Fontenele-Neto JD, Borges DR, Kouyoumdjian M (2003). "Localization of EP24.15, a major liver kininase". J. Histochem. Cytochem. 51 (1): 125–7. doi:10.1177/002215540305100115. PMID 12502762.
York IA, Mo AX, Lemerise K, et al. (2003). "The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation". Immunity. 18 (3): 429–40. doi:10.1016/S1074-7613(03)00058-X. PMID 12648459.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW (2004). "Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization". J. Biol. Chem. 279 (19): 20480–9. doi:10.1074/jbc.M400795200. PMID 14998993.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Saric T, Graef CI, Goldberg AL (2004). "Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases". J. Biol. Chem. 279 (45): 46723–32. doi:10.1074/jbc.M406537200. PMID 15328361.
Shivakumar BR, Wang Z, Hammond TG, Harris RC (2005). "EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor". Cell Biochem. Funct. 23 (3): 195–204. doi:10.1002/cbf.1176. PMID 15376229. S2CID 5695331.

v t e PDB gallery
1s4b: Crystal structure of human thimet oligopeptidase. 2o36: Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site

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