インスリシン

インスリシン(Insulysin、EC 3.4.24.56)は、酵素である^[1]^[2]^[3]^[4]^[5]。この酵素は、インスリン、グルカゴンやその他のポリペプチドを分解する。タンパク質には作用しない。

出典[編集]

^ Duckworth, W.C. (1988). “Insulin degradation: mechanisms, products, and significance”. Endocrine Rev. 9: 319–345. PMID 3061785.
^ Affholter, J.A., Hsieh, C.-L., Francke, U. and Roth, R.A. (1990). “Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes”. Mol. Endocrinol. 4: 1125–1135. PMID 2293021.
^ Duckworth, W.C., Hamel, F.G., Bennett, R., Ryan, M.P. and Roth, R.A. (1990). “Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin”. J. Biol. Chem. 265: 2984–2987. PMID 1689296.
^ Kuo, W.-L., Gehm, B.D. and Rosner, M.R. (1990). “Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme”. Mol. Endocrinol. 4: 1580–1591. PMID 2126597.
^ Ding, L., Becker, A.B., Suzuki, A. and Roth, R.A. (1992). “Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III”. J. Biol. Chem. 267: 2414–2420. PMID 1733942.