Abanohil (IUPAC ) ime 2-(6,7-dimetoksi-3,4-dihidro-1H -izohinolin-2-il)-6,7-dimetoksihinolin-4-amin Klinički podaci Identifikatori CAS broj 90402-40-7 ATC kod nije dodeljen PubChem [ 1] [ 2] 164089 ChemSpider [ 3] 143896 UNII F738MWY53L Y ChEMBL [ 4] CHEMBL324090 Y Hemijski podaci Formula C 22 H 25 N 3 O 4 Mol. masa 395,452 g/mol SMILES eMolekuli PubHem InChI InChI=1S/C22H25N3O4/c1-26-18-7-13-5-6-25(12-14(13)8-19(18)27-2)22-10-16(23)15-9-20(28-3)21(29-4)11-17(15)24-22/h7-11H,5-6,12H2,1-4H3,(H2,23,24) Y Y
Farmakoinformacioni podaci Trudnoća ? Pravni status
Abanohil je antagonist α1-adrenergičkog receptora .[ 5]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Tham, TC; Guy, S; Shanks, RG; Harron, DW (1992). „Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man” . British Journal of Clinical Pharmacology 33 (4): 405–9. PMC 1381330 . PMID 1349492 .
Agonisti :
5-FNE •
6-FNE •
Amidefrin •
Anisodamin •
Anisodin •
Cirazolin •
Dipivefrin •
Dopamin •
Efedrin •
Epinefrin (Adrenalin) •
Etilefrin •
Etilnorepinefrin •
Indanidin •
Levonordefrin •
Metaraminol •
Metoksamin •
Metildopa •
Midodrin •
Nafazolin •
Norepinefrin (Noradrenalin) •
Oktopamin •
Oksimetazolin •
Fenilefrin •
Fenilpropanolamin •
Pseudoefedrin •
Sinefrin •
Tetrahidrozolin Antagonisti :
Abanohil •
Adimolol •
Ajmalicin •
Alfuzosin •
Amosulalol •
Arotinolol •
Atiprosin •
Benoksatian •
Buflomedil •
Bunazosin •
Karvedilol •
CI-926 •
Korinantin •
Dapiprazol •
DL-017 •
Domesticin •
Doksazosin •
Eugenodilol •
Fenspirid •
GYKI-12,743 •
GYKI-16,084 •
Indoramin •
Ketanserin •
L-765,314 •
Labetalol •
Mefendioksan •
Metazosin •
Monatepil •
Moksisilit (Timoksamin) •
Naftopidil •
Nantenin •
Neldazosin •
Nicergolin •
Niguldipin •
Pelanserin •
Fendioksan •
Fenoksibenzamin •
Fentolamin •
Piperoksan •
Prazosin •
Hinazosin •
Ritanserin •
RS-97,078 •
SGB-1,534 •
Silodosin •
SL-89.0591 •
Spiperon •
Talipeksol •
Tamsulosin •
Terazosin •
Tibalosin •
Tiodazosin •
Tipentosin •
Tolazolin •
Trimazosin •
Upidosin •
Urapidil •
Zolertin * Mnogi TCA , TeCA , antipsihotici , ergolini , i neki piperazini kao što su buspiron , trazodon , nefazodon , etoperidon , i mepiprazol takođe antagoniziraju α1 -adrenergičke receptore, što doprinosi njihovim nuspojavama.
French
Deutsch
