| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 7, 2018 | Insidious: The Last Key | $2,988,153 | Tad Jones: The Hero Returns (#5), Stronger (#9) |
| 2 | January 14, 2018 | The Shape of Water | $3,348,084 | Una Mujer sin Filtro (#2), Inside (#10) |
| 3 | January 21, 2018 | $2,035,448 | The Commuter (#2), La Leyenda del Charro Negro (#3), Downsizing (#5) |
| 4 | January 28, 2018 | $1,830,105 | Lo Más Sencillo es Complicarlo Todo (#4), Woody Woodpecker (#5), Molly's Game (#9), Three Billboards Outside Ebbing, Missouri (#10) |
| 5 | February 4, 2018 | Maze Runner: The Death Cure | $3,093,302 | The Little Vampire 3D (#3), Call Me by Your Name (#10) |
| 6 | February 11, 2018 | Fifty Shades Freed | $2,727,505 | La Boda de Valentina (#2), Paddington 2 (#4), The 15:17 to Paris (#7) |
| 7 | February 18, 2018 | Black Panther | $9,207,156 | All the Money in the World (#4), Lady Bird (#8) |
| 8 | February 25, 2018 | $5,046,780 | Cómplices (#2), Den of Thieves (#5), The Midnight Man (#6), Early Man (#7), I, Tonya (#9) |
| 9 | March 4, 2018 | $2,884,350 | Red Sparrow (#2), Satan's Slaves (#6), Father Figures (#7) |
| 10 | March 11, 2018 | $1,594,664 | Winchester (#2), Marcianos vs. Mexicanos (#4), Death Wish (#6), 12 Strong (#9), Épouse-moi Mon Pote (#10) |
| 11 | March 18, 2018 | Tomb Raider | $2,166,923 | Peter Rabbit (#2), Todo Mal (#5), Based on a True Story (#9) |
| 12 | March 25, 2018 | Pacific Rim Uprising | $4,415,729 | Tuya, Mía... Te la Apuesto (#5), Mary Magdalene (#8), L'Amant Double (#10) |
| 13 | April 1, 2018 | Ready Player One | $2,989,902 | Hasta que la Boda nos Separe (#3), A Wrinkle in Time (#4), Sherlock Gnomes (#5) |
| 14 | April 8, 2018 | A Quiet Place | $2,683,042 | The Hurricane Heist (#3), Mazinger Z: Infinity (#4), Game Night (#7), La 4ª Compañía (#10) |
| 15 | April 15, 2018 | Rampage | $4,932,196 | Love, Simon (#3), Ploey: You Never Fly Alone (#6) |
| 16 | April 22, 2018 | $3,005,969 | Truth or Dare (#2), Gnome Alone (#6) |
| 17 | April 29, 2018 | Avengers: Infinity War | $25,382,566 | L'un Dans L'autre (#8) |
| 18 | May 6, 2018 | $8,665,742 | The Strangers: Prey at Night (#2), 24 Hours to Live (#3), Paul, Apostle of Christ (#6), Isle of Dogs (#7) |
| 19 | May 13, 2018 | Overboard | $11,213,179 | Nada a Perder (#4), The Ritual (#6), Tully (#9), Slumber (#10) |
| 20 | May 20, 2018 | Deadpool 2 | $8,798,335 | The Fixies (#4), Campeones (#5), Gringo (#7) |
| 21 | May 27, 2018 | $3,572,786 | Solo: A Star Wars Story (#2), Blockers (#5), Midnight Sun (#6), Book Club (#7), El Ángel en el Reloj (#8), You Were Never Really Here (#9) |
| 22 | June 3, 2018 | $1,804,831 | I Feel Pretty (#4), The Crucifixion (#6), Eres mi Pasión (#7), The Little Witch (#9) |
| 23 | June 10, 2018 | Ocean's 8 | $2,445,381 | Hereditary (#2) |
| 24 | June 17, 2018 | Incredibles 2 | $12,097,243 | El Habitante (#3), Madame (#7) |
| 25 | June 24, 2018 | Jurassic World: Fallen Kingdom | $10,311,092 | How to Talk to Girls at Parties (#10) |
| 26 | July 1, 2018 | $6,214,842 | A Tí Te Quería Encontrar (#3), Sicario: Day of the Soldado (#4), Life of the Party (#5), The Mimic (#7), Mission Kathmandu: The Adventures of Nelly & Simon (#8) |
| 27 | July 8, 2018 | Ant-Man and the Wasp | $6,753,487 | Still/Born (#5), Happy End (#9), Locos de Amor (#10) |
| 28 | July 15, 2018 | Hotel Transylvania 3: A Monster Vacation | $7,173,180 | Skyscraper (#2), Ghostland (#6), Cigarettes et Chocolat Chaud (#9) |
| 29 | July 22, 2018 | $3,964,454 | The First Purge (#2), Adrift (#6), Tag (#8), Attack on Titan: The Roar of Awakening (#10) |
| 30 | July 29, 2018 | Mission: Impossible – Fallout | $4,929,785 | Más Sabe el Diablo por Viejo (#4). Here Comes the Grump (#6), Wildling (#10) |
| 31 | August 5, 2018 | Ya Veremos | $3,289,516 | Christopher Robin (#3), The Darkest Minds (#5) |
| 32 | August 12, 2018 | The Meg | $6,307,774 | Loving Pablo (#6), Luis and His Friends from Outer Space (#7), Bad Samaritan (#9) |
| 33 | August 19, 2018 | $3,723,016 | The Equalizer 2 (#2), Mamma Mia! Here We Go Again (#3), Plan V (#6), Ghost Stories (#10) |
| 34 | August 26, 2018 | $2,263,221 | Slender Man (#2), Teen Titans Go! To the Movies (#3), The Spy Who Dumped Me (#4), Grease: 40th Anniversary (#9) |
| 35 | September 2, 2018 | Alpha | $1,772,061 | Mile 22 (#3), Ana y Bruno (#6), Tiempo Compartido (#10) |
| 36 | September 9, 2018 | The Nun | $10,354,752 | The Little Mermaid (#3) |
| 37 | September 16, 2018 | $3,390,898 | Johnny English Strikes Again (#2), El Día de la Unión (#5), Gotti (#6) |
| 38 | September 23, 2018 | The Predator | $3,268,543 | The Stolen Princess (#5), Crazy Rich Asians (#6), Malacopa (#7), Searching (#9), A Simple Favor (#10) |
| 39 | September 30, 2018 | Smallfoot | $3,474,892 | Papillon (#5), Recuperando a mi Ex (#6), Hotel Artemis (#8) |
| 40 | October 7, 2018 | Venom | $10,067,272 | La Gran Promesa (#8), Ravenous (#9) |
| 41 | October 14, 2018 | $4,471,095 | Goosebumps 2: Haunted Halloween (#2), A Star Is Born (#3), Te Juro Que Yo No Fui (#5), Ni Tú Ni Yo (#6), Bleeding Steel (#7) |
| 42 | October 21, 2018 | Halloween | $5,021,190 | Si Yo Fuera Tú (#5), Cinderella and the Secret Prince (#8) |
| 43 | October 28, 2018 | $2,364,505 | The House with a Clock in Its Walls (#2), Coco (#3), Museo (#5), Replicas (#8) |
| 44 | November 4, 2018 | Bohemian Rhapsody | $5,679,029 | The Nutcracker and the Four Realms (#2), Inquilinos (#5), Hunter Killer (#6), Silencio (#10) |
| 45 | November 11, 2018 | $4,030,817 | The Girl in the Spider's Web (#3), Overlord (#4), First Man (#5), Lino: The Movie (#7) |
| 46 | November 18, 2018 | Fantastic Beasts: The Crimes of Grindelwald | $6,119,028 | Loca por el Trabajo (#3) |
| 47 | November 25, 2018 | Ralph Breaks the Internet | $6,167,792 | Peppermint (#4), Instant Family (#6), Gonjiam: Haunted Asylum (#7), Chivas: La Película (#9), The Kindergarten Teacher (#10) |
| 48 | December 2, 2018 | $4,064,392 | Robin Hood (#3), The Possession of Hannah Grace (#4), Widows (#7), My Hero Academia: Two Heroes (#8) |
| 49 | December 9, 2018 | The Grinch | $5,447,527 | Mi Pequeño Gran Hombre (#3), Hell Fest (#7) |
| 50 | December 16, 2018 | Aquaman | $6,643,640 | 211 (#7), Unfriended: Dark Web (#9) |
| 51 | December 23, 2018 | $3,922,942 | Bumblebee (#2), Life Itself (#4) |
| 52 | December 30, 2018 | $3,251,995 | Spider-Man: Into the Spider-Verse (#2), Perfectos Desconocidos (#4),Mary Poppins Returns (#6), Muse (#7), Monsieur Je-Sais-Tout (#10) |
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