| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 3, 2021 | Wonder Woman 1984 | $391,891 | Come Away (#3), The 100 Candles Game (#6) |
| 2 | January 10, 2021 | $219,834 | Prityazhenie 2 (#3), The Head Hunter (#4) |
| 3 | January 17, 2021 | $136,373 | Dreambuilders (#5), Harry Potter and the Philosopher's Stone (#6), Harry Potter and the Prisoner of Azkaban (#10) |
| 4 | January 24, 2021 | $115,147 | The Owners (#3), Harry Potter and the Goblet of Fire (#6) |
| 5 | January 31, 2021 | The Croods: A New Age | $92,350 | Vdova (#3), Harry Potter and the Deathly Hallows – Part 1 (#6) |
| 6 | February 7, 2021 | $84,631 | Amjeon (#6) |
| 7 | February 14, 2021 | Wonder Woman 1984 | $80,190 | The Captain (#3), Bigfoot Family (#8) |
| 8 | February 21, 2021 | Tom & Jerry | $372,024 | Monster Hunter (#2) |
| 9 | February 28, 2021 | $397,978 | Wild Mountain Thyme (#4) |
| 10 | March 7, 2021 | $419,019 | Chaos Walking (#2), 10 Things We Should Do Before We Break Up (#6) |
| 11 | March 14, 2021 | $324,002 | Juega Conmigo (#3), The Little Things (#4), Pinocchio (#5), Fate Stay Night (#7) |
| 12 | March 21, 2021 | The Marksman | $419,387 | Ooops! The Adventure Continues (#6) |
| 13 | March 28, 2021 | Godzilla vs. Kong | $5,344,112 | |
| 14 | April 4, 2021 | $3,840,302 | The War with Grandpa (#2), The Father (#5), Violet Evergarden: The Movie (#6) |
| 15 | April 11, 2021 | $1,794,082 | Relic (#3), Después de Ti (#4), The Lord of the Rings: The Fellowship of the Ring (#7), Promising Young Woman (#9), The Lord of the Rings: The Return of the King (#10) |
| 16 | April 18, 2021 | $1,014,392 | Mortal Kombat (#2), Nomadland (#10) |
| 17 | April 25, 2021 | The Unholy | $1,273,193 | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train (#2), Todo lo Invisible (#6) |
| 18 | May 2, 2021 | $1,302,019 | Nobody (#4), Penguin Bloom (#7), Mara (#8), No, Porque me Enamoro (#9) |
| 19 | May 9, 2021 | $656,865 | El Exorcismo de Carmen Farías (#2), Half Brothers (#3) |
| 20 | May 16, 2021 | $476,081 | Peter Rabbit 2: The Runaway (#2), Spiral (#3), Those Who Wish Me Dead (#5) |
| 21 | May 23, 2021 | Wrath of Man | $469,098 | Los Trapos Sucios se Lavan en Casa (#5), The Seventh Day (#6) |
| 22 | May 30, 2021 | Cruella | $2,565,019 | Breaking Surface (#6), Boss Level (#7) |
| 23 | June 6, 2021 | The Conjuring: The Devil Made Me Do It | $5,982,998 | My Salinger Year (#5) |
| 24 | June 13, 2021 | $3,093,813 | A Quiet Place Part II (#2), Spirit Untamed (#4), Another Round (#5), Hitman's Wife's Bodyguard (#6), Los Lobos (#9) |
| 25 | June 20, 2021 | $1,499,021 | In the Heights (#6), Cosas Imposibles (#7) |
| 26 | June 27, 2021 | Fast & Furious 9 | $9,072,091 | |
| 27 | July 4, 2021 | $4,654,917 | The Forever Purge (#2) |
| 28 | July 11, 2021 | Black Widow | $4,712,081 | I Carry You With Me (#8) |
| 29 | July 18, 2021 | Space Jam: A New Legacy | $3,197,233 | El Mesero (#3), Lake of Death (#6), Someone, Somewhere (#10) |
| 30 | July 25, 2021 | $1,354,821 | The Boss Baby: Family Business (#2), Old (#3), Snake Eyes (#7) |
| 31 | August 1, 2021 | Jungle Cruise | $1,063,394 | The Comeback Trail (#9) |
| 32 | August 8, 2021 | The Suicide Squad | $1,944,021 | Blackpink: The Movie (#4) |
| 33 | August 15, 2021 | $834,294 | Free Guy (#2), Un Rescate de Huevitos (#3), Don't Breathe 2 (#4) |
| 34 | August 22, 2021 | PAW Patrol: The Movie | $864,000 | Reminiscence (#6), Ni Tuyo, Ni Mía (#7) |
| 35 | August 29, 2021 | $494,019 | Candyman (#3), Way Down (#6) |
| 36 | September 5, 2021 | Shang-Chi and the Legend of the Ten Rings | $2,400,000 | After We Fell (#3) |
| 37 | September 12, 2021 | $1,382,924 | The Ice Road (#2), Malignant (#3) |
| 38 | September 19, 2021 | $1,204,943 | Chilangolandia (#2), Escape Room: Tournament of Champions (#5), Ainbo: Spirit of the Amazon (#6), Cry Macho (#9) |
| 39 | September 26, 2021 | $664,849 | The Night House (#2), CODA (#3), Black Water: Abyss (#6) |
| 40 | October 3, 2021 | No Time to Die | $2,394,092 | Show Me the Father (#10) |
| 41 | October 10, 2021 | Venom: Let There Be Carnage | $8,013,749 | Fatima (#9) |
| 42 | October 17, 2021 | $4,396,504 | Halloween Kills (#2), The Addams Family 2 (#3), The Last Duel (#5) |
| 43 | October 24, 2021 | Dune | $2,289,210 | Ron's Gone Wrong (#5), The Evil Next Door (#8), Skyfire (#9), You Are Not Alone (#10) |
| 44 | October 31, 2021 | Venom: Let There Be Carnage | $1,079,290 | Antlers (#3), Last Night in Soho (#6), Monster Family 2 (#8) |
| 45 | November 7, 2021 | Eternals | $5,681,151 | |
| 46 | November 14, 2021 | $4,605,741 | Harry Potter and the Philosopher's Stone (#3), Chernobyl: Abyss (#5), Rock Dog 2: Rock Around the Park (#8), Sea Fever (#10) |
| 47 | November 21, 2021 | Ghostbusters: Afterlife | $2,304,347 | |
| 48 | November 28, 2021 | Encanto | $1,513,582 | House of Gucci (#3), Resident Evil: Welcome to Raccoon City (#5), Vivo (#8) |
| 49 | December 5, 2021 | $1,073,732 | King Richard (#4), Run Hide Fight (#8) Playhouse (#10) |
| 50 | December 12, 2021 | $703,941 | Clifford the Big Red Dog (#2), West Side Story (#9), The Matrix (#10) |
| 51 | December 19, 2021 | Spider-Man: No Way Home | $32,400,000 | |
| 52 | December 26, 2021 | $9,926,800 | Sing 2 (#2), The Matrix Resurrections (#3) |
| 53 | January 2, 2022 | $11,230,920 | The King's Man (#4), Karem, La Posesión (#5), Lamb (#9) |
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