French
DeutschUCP2
Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.[5]
Gene
[edit]Chromosomal order is 5'-UCP3-UCP2-3'.[6]
Tissue distribution
[edit]In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues[7] including the kidney, liver, GI tract, brain, and skeletal muscle.
Function
[edit]Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS).
The exact mechanisms of anion transfer by UCPs are not known.[8] UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.[9]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochemical and Biophysical Research Communications. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
- ^ "Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)".
- ^ "Tissue expression of UCP2 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-08-20.
- ^ Garlid KD, Jabůrek M, Ježek P, Vařecha M (2000-08-15). "How do uncoupling proteins uncouple?". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1459 (2–3): 383–389. doi:10.1016/S0005-2728(00)00175-4. ISSN 0005-2728. PMID 11004454.
- ^ Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, et al. (December 2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (4): 435–439. doi:10.1038/82565. PMID 11101840. S2CID 29831657.
Further reading
[edit]- Ricquier D, Bouillaud F (Jan 2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". The Biochemical Journal. 345 Pt 2 (Pt 2): 161–179. doi:10.1042/0264-6021:3450161. PMC 1220743. PMID 10620491.
- Saleh MC, Wheeler MB, Chan CB (Feb 2002). "Uncoupling protein-2: evidence for its function as a metabolic regulator". Diabetologia. 45 (2): 174–187. doi:10.1007/s00125-001-0737-x. PMID 11935148.
- Muzzin P (Apr 2002). "The uncoupling proteins". Annales d'Endocrinologie. 63 (2 Pt 1): 106–110. PMID 11994670.
- Horvath TL, Diano S, Barnstable C (Jun 2003). "Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector". Biochemical Pharmacology. 65 (12): 1917–1921. doi:10.1016/S0006-2952(03)00143-6. PMID 12787871.
- Paradis E, Clavel S, Bouillaud F, Ricquier D, Richard D (Dec 2003). "Uncoupling protein 2: a novel player in neuroprotection". Trends in Molecular Medicine. 9 (12): 522–525. doi:10.1016/j.molmed.2003.10.009. PMID 14659466.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, et al. (Mar 1997). "Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia". Nature Genetics. 15 (3): 269–272. doi:10.1038/ng0397-269. PMID 9054939. S2CID 13421247.
- Gimeno RE, Dembski M, Weng X, et al. (May 1997). "Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis". Diabetes. 46 (5): 900–906. doi:10.2337/diabetes.46.5.900. PMID 9133562.
- Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, et al. (May 1997). "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression". FEBS Letters. 408 (1): 39–42. Bibcode:1997FEBSL.408...39B. doi:10.1016/S0014-5793(97)00384-0. PMID 9180264. S2CID 33808140.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hodny Z, Kolarova P, Rossmeisl M, Horakova M, Nibbelink M, Penicaud L, et al. (Mar 1998). "High expression of uncoupling protein 2 in foetal liver". FEBS Letters. 425 (2): 185–190. Bibcode:1998FEBSL.425..185H. doi:10.1016/S0014-5793(98)00230-0. PMID 9559644. S2CID 35050170.
- Argyropoulos G, Brown AM, Peterson R, Likes CE, Watson DK, Garvey WT (Apr 1998). "Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects". Diabetes. 47 (4): 685–687. doi:10.2337/diabetes.47.4.685. PMID 9568704. S2CID 38803735.
- Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke KM, et al. (1999). "Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene". Life Sciences. 64 (3): PL41 – PL50. doi:10.1016/S0024-3205(98)00555-4. PMID 10027754.
- Pecqueur C, Cassard-Doulcier AM, Raimbault S, Miroux B, Fleury C, Gelly C, et al. (Feb 1999). "Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene". Biochemical and Biophysical Research Communications. 255 (1): 40–46. doi:10.1006/bbrc.1998.0146. PMID 10082652.
- Jezek P, Urbánková E (Jan 2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343. S2CID 8541209.
- Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, et al. (May 2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". European Journal of Biochemistry. 267 (9): 2680–2687. doi:10.1046/j.1432-1327.2000.01285.x. PMID 10785390.
- Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, et al. (Jun 2001). "A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans". Nature Genetics. 28 (2): 178–183. doi:10.1038/88911. PMID 11381268. S2CID 29550924.
- Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, et al. (Jan 2002). "Superoxide activates mitochondrial uncoupling proteins". Nature. 415 (6867): 96–99. Bibcode:2002Natur.415...96E. doi:10.1038/415096a. PMID 11780125. S2CID 4349744.
- Rupprecht A, Sittner D, Smorodchenko A, Hilse KE, Goyn J, Moldzio R, et al. (2014). "Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function". PLOS ONE. 9 (2): e88474. Bibcode:2014PLoSO...988474R. doi:10.1371/journal.pone.0088474. PMC 3921169. PMID 24523901.
- Rupprecht A, Bräuer AU, Smorodchenko A, Goyn J, Hilse KE, Shabalina IG, et al. (2012). "Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation". PLOS ONE. 7 (8): e41406. Bibcode:2012PLoSO...741406R. doi:10.1371/journal.pone.0041406. PMC 3411681. PMID 22870219.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |