C6 (complemento) , a enciclopedia libre

C6
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes C6, complemento C6 ;
Símbolo	C6 (HGNC: 1339)
Identificadores; externos	OMIM: 217050 ; MGI: 88233 ; HomoloGene: 47 ; EBI: C6; GeneCards: Xene C6; UniProt: C6;
Locus	Cr. 5 p13.1
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Ortólogos
Especies
Humano	Rato
Entrez
729	12274
Ensembl
Véxase HS	Véxase MM
UniProt
P13671	n/a
RefSeq; (ARNm)
NM_000065	NM_016704
RefSeq; (proteína) NCBI
NP_000056	n/a
Localización (UCSC)
Cr. hg5:; 41.14 – 41.26 Mb	Cr. 15:; 4.76 – 4.84 Mb
PubMed (Busca)
729 ;	12274

O compoñente do complemento 6 ou C6 é unha proteína que nos humanos está codificada no xene C6 do cromosoma 5.^[1]

O compoñente do complemento 6 é unha proteína implicada nas reaccións do sistema do complemento. É un dos compoñentes do complexo de ataque á membrana que pode inserirse na membrana plasmática de células bacterianas que deben ser detruídas e producir a lise da célula.

As persoas que teñen deficiencia de C6 teñen maior tendencia a adquirir infeccións bacterianas.^[1]

Notas

↑ ^1,0 ^1,1 "Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729". www.ncbi.nlm.nih.gov. 24 de novembro de 2020. Consultado o 9 de decembro de 2020.

Véxase tamén

Bibliografía

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. PMID 20237496. doi:10.1038/gene.2010.1.
Rajaraman P, Brenner AV, Butler MA, et al. (2009). "Common variation in genes related to innate immunity and risk of adult glioma.". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. PMC 2771723. PMID 19423540. doi:10.1158/1055-9965.EPI-08-1041.
Cerhan JR, Novak AJ, Fredericksen ZS, et al. (2009). "Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.". Br. J. Haematol. 145 (5): 614–23. PMC 2820509. PMID 19344414. doi:10.1111/j.1365-2141.2009.07675.x.
Han S, Lan Q, Park AK, et al. (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia.". Hum. Immunol. 71 (7): 727–30. PMC 2967770. PMID 20438785. doi:10.1016/j.humimm.2010.04.004.
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Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. PMC 2775832. PMID 19913121. doi:10.1016/j.ajhg.2009.10.014.
Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system.". Annu. Rev. Biochem. 57: 321–47. PMID 3052276. doi:10.1146/annurev.bi.57.070188.001541.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Eid NA, Hussein AA, Elzein AM, et al. (2010). "Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.". Malar. J. 9: 119. PMC 2877684. PMID 20459687. doi:10.1186/1475-2875-9-119.
Fosbrink M, Cudrici C, Tegla CA, et al. (2009). "Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.". Exp. Mol. Pathol. 86 (2): 87–94. PMC 2699899. PMID 19162005. doi:10.1016/j.yexmp.2008.12.005.
Rajaraman P, Brenner AV, Neta G, et al. (2010). "Risk of meningioma and common variation in genes related to innate immunity.". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. PMC 3169167. PMID 20406964. doi:10.1158/1055-9965.EPI-09-1151.
Ennis S, Jomary C, Mullins R, et al. (2008). "Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.". Lancet 372 (9652): 1828–34. PMC 5983350. PMID 18842294. doi:10.1016/S0140-6736(08)61348-3.
Soejima M, Tachida H, Tsuneoka M, et al. (2005). "Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection.". Ann. Hum. Genet. 69 (Pt 3): 239–52. PMID 15845028. doi:10.1046/j.1529-8817.2005.00165.x.
Bulla R, Bossi F, Agostinis C, et al. (2009). "Complement production by trophoblast cells at the feto-maternal interface.". J. Reprod. Immunol. 82 (2): 119–25. PMID 19665237. doi:10.1016/j.jri.2009.06.124.
Gancz D, Donin N, Fishelson Z (2009). "Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.". Mol. Immunol. 47 (2–3): 310–7. PMID 19864026. doi:10.1016/j.molimm.2009.09.016.
Parham KL, Roberts A, Thomas A, et al. (2007). "Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family.". Mol. Immunol. 44 (10): 2756–60. PMID 17257682. doi:10.1016/j.molimm.2006.11.022.
Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics 7 (11): 1775–85. PMID 17474147. doi:10.1002/pmic.200601006.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. PMC 2945168. PMID 20628086. doi:10.2337/dc10-0452.

Ligazóns externas

Complement C6 Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.

Este artigo é, polo de agora, só un bosquexo. Traballa nel para axudar a contribuír a que a Galipedia mellore e medre.

[entrez-1] 1,0 ^1,1 "Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729". www.ncbi.nlm.nih.gov. 24 de novembro de 2020. Consultado o 9 de decembro de 2020.

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