N-metil-D-aspartinska kiselina – Wikipedija / Википедија

N-Metil-D-aspartinska kiselina
Ball and stick model of N-methyl-D-aspartic acid	Spacefill model of N-methyl-D-aspartic acid
	(2R)-2-(Metolamino)butandioinska kiselina
Identifikacija
Abrevijacija	NMDA
CAS registarski broj	6384-92-5
PubChem	22880
ChemSpider	21436
KEGG	C12269
MeSH	N-Methylaspartate
ChEBI	31882
ChEMBL	CHEMBL291278
RTECS registarski broj toksičnosti	CI9457000
Bajlštajn	1724431
Jmol-3D slike	Slika 1
SMILES
	CN[C@H](CC(O)=O)C(O)=O
InChI
	InChI=1 S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 ; Kod: HOKKHZGPKSLGJE-GSVOUGTGSA-N
Svojstva
Molekulska formula	C5H9NO4
Molarna masa	147.13 g mol−1
Agregatno stanje	Beli, neprozirni kritali
Miris	Bez mirisa
Tačka topljenja	189-190 °C, 462-463 K, 372-374 °F
log P	1,39
pKa	2,206
Baznost (pKb)	11,791
Opasnost
S-oznake	S22, S24/25
LD50	137 mg kg−1 (intraperitonealno, miš)
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

N-Metil-D-aspartinska kiselina (N-metil-D-aspartat, NMDA) je aminokiselinski derivat koji deluje kao specifični agonist NMDA receptora. NMDA oponaša dejstvo glutamata, neurotransmitera koji je endogeni ligand tog receptora. Za razliju od glutamata, NMDA se jedino vezuje za i reguliše NMDA receptore, i nema efekta na druge tipove glutamatnih receptora (kao što su AMPA i kainatni). NMDA receptori su posebno važni kad postanu prekomerno aktivni tokom povlačenja alkohola, a to uzrokuje simptome poput agitacije, i u nekim slučajevima epileptičke napade.

Reference

↑ „N-Methylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24. 6. 2005.. Identification and Related Records. Pristupljeno 9. 1. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Literatura

Mathias-Costa Blaise, Ramanathan Sowdhamini, Metpally Rau Raghu Prasad, Nithyananda Pradhan (2004). „Evolutionary trace analysis of ionotropic glutamate receptor sequences and modeling the interactions of agonists with different NMDA receptor subunits”. J. Mol. Model. 10 (5-6): 305–16. DOI:10.1007/s00894-004-0196-7. PMID 15597199.

Vanjske veze

[1] „N-Methylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24. 6. 2005.. Identification and Related Records. Pristupljeno 9. 1. 2012.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

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