FGF10 — Вікіпедія

FGF10
Наявні структури
PDB	Пошук ортологів: PDBe RCSB
Список кодів PDB
	1NUN
Ідентифікатори
Символи	FGF10, fibroblast growth factor 10
Зовнішні ІД	OMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10
Пов'язані генетичні захворювання
	рак простати, LADD syndrome
Онтологія гена
Молекулярна функція	• heparin binding; • type 2 fibroblast growth factor receptor binding; • growth factor activity; • GO:0001948, GO:0016582 protein binding; • fibroblast growth factor receptor binding; • chemoattractant activity; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Клітинна компонента	• extracellular region; • клітинне ядро; • cell surface; • GO:0005578 Позаклітинна матриця; • клітинна мембрана; • міжклітинний простір; • collagen-containing extracellular matrix;
Біологічний процес	• bud outgrowth involved in lung branching; • limb bud formation; • organ growth; • semicircular canal morphogenesis; • embryonic pattern specification; • bud elongation involved in lung branching; • positive regulation of canonical Wnt signaling pathway; • muscle cell fate commitment; • сльозовиділення; • positive regulation of Ras protein signal transduction; • positive regulation of urothelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • limb development; • radial glial cell differentiation; • female genitalia morphogenesis; • mesonephros development; • odontogenesis of dentin-containing tooth; • prostatic bud formation; • blood vessel remodeling; • regulation of saliva secretion; • Ангіогенез; • establishment of mitotic spindle orientation; • positive regulation of ERK1 and ERK2 cascade; • embryonic digestive tract morphogenesis; • animal organ morphogenesis; • hair follicle morphogenesis; • metanephros development; • lung saccule development; • lung epithelium development; • positive regulation of Notch signaling pathway; • negative regulation of cell population proliferation; • branch elongation involved in salivary gland morphogenesis; • branching involved in salivary gland morphogenesis; • positive regulation of white fat cell proliferation; • bronchiole morphogenesis; • limb morphogenesis; • blood vessel morphogenesis; • lung development; • thymus development; • positive regulation of fibroblast proliferation; • negative regulation of cell differentiation; • ERK1 and ERK2 cascade; • positive regulation of epithelial cell migration; • positive regulation of mitotic cell cycle; • spleen development; • smooth muscle cell differentiation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of Wnt signaling pathway; • Harderian gland development; • protein localization to cell surface; • respiratory system development; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • metanephros morphogenesis; • pancreas development; • mammary gland bud formation; • positive chemotaxis; • mesenchymal-epithelial cell signaling involved in lung development; • positive regulation of hair follicle cell proliferation; • lacrimal gland development; • positive regulation of MAPK cascade; • диференціація клітин; • positive regulation of keratinocyte proliferation; • positive regulation of ATP-dependent activity; • positive regulation of epithelial cell proliferation involved in wound healing; • epithelial cell differentiation; • organ induction; • positive regulation of epithelial cell proliferation; • epidermis morphogenesis; • Загоєння ран; • epithelial cell proliferation; • regulation of activin receptor signaling pathway; • positive regulation of DNA replication; • хемотаксис; • embryonic genitalia morphogenesis; • salivary gland development; • positive regulation of keratinocyte migration; • response to lipopolysaccharide; • thyroid gland development; • keratinocyte proliferation; • semicircular canal fusion; • mammary gland specification; • epithelial cell migration; • white fat cell differentiation; • регуляція експресії генів; • lung alveolus development; • branching morphogenesis of an epithelial tube; • embryonic digestive tract development; • lung proximal/distal axis specification; • fibroblast growth factor receptor signaling pathway involved in mammary gland specification; • actin cytoskeleton reorganization; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • pituitary gland development; • response to estradiol; • secretion by lung epithelial cell involved in lung growth; • mesenchymal cell differentiation involved in lung development; • lung morphogenesis; • GO:1904578 response to organic cyclic compound; • somatic stem cell population maintenance; • tissue regeneration; • otic vesicle formation; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • male genitalia morphogenesis; • GO:1900404 positive regulation of DNA repair; • salivary gland morphogenesis; • MAPK cascade; • embryonic camera-type eye development; • induction of positive chemotaxis; • urothelial cell proliferation; • animal organ formation; • fibroblast growth factor receptor signaling pathway; • regulation of smoothened signaling pathway; • determination of left/right symmetry; • inner ear morphogenesis; • positive regulation of cell population proliferation; • submandibular salivary gland formation; • type II pneumocyte differentiation; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • digestive tract development; • regulation of epithelial cell proliferation; • epithelial tube branching involved in lung morphogenesis; • positive regulation of lymphocyte proliferation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • positive regulation of G1/S transition of mitotic cell cycle;
	Джерела:Amigo / QuickGO
Ортологи
	2255
	14165
	ENSG00000070193
	ENSMUSG00000021732
	O15520
	O35565
	NM_004465
	NM_008002
	NP_004456
	NP_032028
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

FGF10 (англ. Fibroblast growth factor 10) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. ^[4] Довжина поліпептидного ланцюга білка становить 208 амінокислот, а молекулярна маса — 23 436^[5].

Послідовність амінокислот

10	20	30	40	50
MWKWILTHCA	SAFPHLPGCC	CCCFLLLFLV	SSVPVTCQAL	GQDMVSPEAT
NSSSSSFSSP	SSAGRHVRSY	NHLQGDVRWR	KLFSFTKYFL	KIEKNGKVSG
TKKENCPYSI	LEITSVEIGV	VAVKAINSNY	YLAMNKKGKL	YGSKEFNNDC
KLKERIEENG	YNTYASFNWQ	HNGRQMYVAL	NGKGAPRRGQ	KTRRKNTSAH
FLPMVVHS

A: Аланін
 C: Цистеїн
 D: Аспарагінова кислота
 E: Глутамінова кислота
 F: Фенілаланін
 G: Гліцин
 H: Гістидин
 I: Ізолейцин
 K: Лізин
 L: Лейцин
 M: Метіонін
 N: Аспарагін
 P: Пролін
 Q: Глутамін
 R: Аргінін
 S: Серин
 T: Треонін
 V: Валін
 W: Триптофан
 
 Y: Тирозин

Кодований геном білок за функцією належить до факторів росту. Секретований назовні.

Література[ред. | ред. код]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Turner N., Grose R. (2010). Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer. 10: 116—129. PMID 20094046 DOI:10.1038/nrc2780
Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B. (2006). LADD syndrome is caused by FGF10 mutations. Clin. Genet. 69: 349—354. PMID 16630169 DOI:10.1111/j.1399-0004.2006.00597.x